tumor protein p63

jump to detail

Synonym

P73L, Keratinocyte transcription factor KET, CUSP, TP63, EEC3, B(p51B), p73H, Chronic ulcerative stomatitis protein, Tumor protein p73-like, p51, OFC8, P63, SHFM4, TP73L, tumor protein p63, KET, RHS, tumor protein p73-like, B(p51A), P73H, LMS, p73L, Tumor protein 63

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:- cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:118.60 eye:17.60 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:77.30 bone marrow:- adipose:- bone:- skin:364.80
GeneChip cerebrum:4.24 cerebellum:4.15 brain stem:4.24 corpus callosum/glia:4.20 pineal gland:- peripheral nerve:4.02 spine:4.04 retina:- eye:- artery/aorta:4.07 vein:4.28 lymphnode:4.09 peripheral blood:- spleen:3.93 thymus:4.05 bone marrow:4.31 adipose:4.27 bone:- skin:4.38
CAGE cerebrum:0.12 cerebellum:- brain stem:0.22 corpus callosum/glia:0.24 pineal gland:0.48 peripheral nerve:- spine:0.86 retina:- eye:- artery/aorta:1.57 vein:1.76 lymphnode:1.96 peripheral blood:- spleen:0 thymus:2.76 bone marrow:- adipose:1.99 bone:- skin:-
RNA-seq cerebrum:0.00 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.00 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:21.90 prostate:101.40 ovary:- testis:26 heart:153.30 muscle:20.10 esophagus:- stomach:- intestine:- colon:8.50     liver/hepato:-        lung:24.40    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:4.08 placenta:3.99 prostate:4.09 ovary:4.11 testis:4.02 heart:4.34 muscle:4.34 esophagus:4.37 stomach:4.13 intestine:4.23 colon:4.37 liver/hepato:4.10 lung:4.20 bladder:- kidney:4.19 pituitary:4.15 thyroid/parathyroid:4.09 adrenal gland:4.14 pancreas:4.28 breast:4.02 salivary:4.32
CAGE uterus:1.81 placenta:2.73 prostate:3.06 ovary:0.07 testis:0.77 heart:0 muscle:4.82 esophagus:4.20 stomach:- intestine:0 colon:0.04     liver/hepato:0    lung:1.27 bladder:2.40 kidney:0.58 pituitary:0.42 thyroid/parathyroid:0.53 adrenal gland:- pancreas:0 breast:1.36 salivary:2.06
RNA-seq uterus:- placenta:- prostate:0 ovary:0.00 testis:1.03 heart:0.00 muscle:3.00 esophagus:- stomach:- intestine:- colon:0.00     liver/hepato:0.00        lung:0.14    bladder:- kidney:0.00 pituitary:- thyroid/parathyroid:0.16 adrenal gland:0.04 pancreas:- breast:0.19 salivary:-

IDs

Refseq ID NM_003722
Gene ID 8626
Unigene ID Hs.137569
Probe set ID 211834_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000073282
GTEx ID ENSG00000073282

Orthologous Gene

Mouse[18]  NM_001127259, NM_001127260, NM_001127261, NM_001127262, NM_001127263, NM_001127264, NM_001127265, NM_011641
Rat[6]  NM_001127339, NM_001127341, NM_001127342, NM_001127343, NM_001127344, NM_019221, NM_001127265, NM_011641

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed  (Pubmed ID)

8695800
8889548
9405685
9618472
9662346
9662378
9703973
9774969
9799226
9799841
10373484
10469295
10485447
10535733
10657951
10744705
10805802
10839977
10935472
11106548
11159940
11181441
11181451
11238924
11248048
11278685
11336476
11462173
11477076
11528512
11532371
11641404
11714701
11727253
11733180
11739646
11787035
11839669
11879774
11893750
11925430
11929852
11932750
11957139
12037717
12086851
12102658
12161593
12185332
12357472
12358808
12368193
12374749
12379767
12379768
12446779
12446784
12477932
12481011
12525544
12533521
12534798
12640112
12653579
12692135
12750249
12782800
12788532
12815266
12939657
12954772
12969350
14519656
14555649
14599865
14654522
14654529
14656652
14684701
14729977
14757278
15001991
15024707
15201986
15254760
15339933
15359011
15367673
15389254
15467455
15489334
15489655
15529180
15539951
15551738
15578720
15611636
15761962
15846104
15875781
15922574
15944736
15965232
15983386
15988020
15988026
16007146
16082248
16133456
16152605
16181796
16187309
16258268
16273188
16273287
16283378
16319057
16319531
16322335
16324199
16343436
16375115
16398404
16406339
16410722
16413471
16417229
16446369
16449968
16462763
16481749
16516862
16575619
16581802
16616891
16618808
16630179
16646404
16679535
16681687
16681688
16715076
16740912
16804722
16831876
16842248
16908849
16979518
17018588
17050669
17106255
17159913
17172858
17188034
17276940
17312919
17336302
17385050
17392828
17399686
17404570
17446929
17498688
17499344
17521434
17525625
17581882
17582001
17599745
17606614
17609671
17615180
17637746
17637751
17688405
17716971
17822623
17880529
17903252
17905096
17915261
17951196
17965458
17984111
17998283
18029348
18037962
18048390
18064689
18085379
18087216
18192965
18194839
18198175
18199584
18203782
18246802
18256694
18256893
18311114
18317223
18328806
18330953
18364388
18411264
18412244
18418053
18432259
18483491
18515319
18593911
18603493
18615589
18626511
18633439
18662989
18676680
18726671
18769144
18792980
18794855
18801085
18806757
18813120
18813784
18831009
18833815
18927586
18937546
18955789
18971778
19032382
19049519
19068396
19089994
19092634
19119599
19124002
19142959
19160863
19170196
19188816
19239083
19239089
19267405
19278431
19282665
19342891
19345189
19347829
19353588
19369629
19402389
19430419
19450441
19451233
19458633
19517019
19526317
19530185
19577853
19578750
19586494
19622632
19625176
19668228
19676060
19690760
19690775
19692168
19700772
19725154
19773378
19781362
19815500
19829080
19843673
19858204
19898465
19898932
19903181
19920075
20016275
20023394
20038814
20052674
20081800
20085233
20100581
20107313
20145131
20150431
20182342
20189848
20211142
20219920
20298673
20308539
20348956
20357260
20379195
20379614
20403333
20410354
20424325
20442293
20445549
20457941
20463571
20523354
20556892
20571051
20607803
20613985
20634891
20638300
20644729
20656547
20714441
20729916
20829881
20855944
20871597
20888799
20950370
20951678
20959455
20962848
20972438
20972454
21036415
21042780
21048031
21063684
21075072
21078104
21088494
21088498
21114965
21115930
21127199
21129360
21150337
21164283
21170261
21181306
21191146
21204238
21234707
21289519
21299870
21300884
21317427
21317878
21319317
21325799
21325887
21326813
21356385
21363924
21364617
21367858
21373745
21402718
21417823
21427767
21434540
21447682
21464285
21478550
21511729
21520071
21527555
21576089
21586512
21610222
21623182
21623385
21631272
21631996
21637289
21643019
21646640
21652629
21674157
21690062
21703418
21705376
21715473
21717589
21725308
21741828
21760596
21765392
21777423
21789189
21802344
21821031
21833468
21880709
21881870
21897369
21898830
21933882
21959367
21965674
21967648
21980285
21986963
21988832
22007675
22020940
22027432
22053213
22056305
22056955
22065540
22069181
22071691
22075982
22076464
22096589
22100306
22158419
22184109
22228303
22240899
22247000
22247550
22249251
22253920
22257901
22287651
22310392
22342398
22356768
22361733
22364861
22367298
22367405
22406481
22441934
22452794
22489697
22491513
22496164
22496369
22538425
22538442
22549865
22553810
22573176
22574117
22575646
22577164
22607287
22623071
22659744
22672905
22673192
22690848
22706304
22740388
22787154
22797724
22855598
22901151
22902906
22935697
22943673
22949650
22951905
22963430
22964638
23015401
23016917
23019126
23028944
23029228
23054955
23071680
23095717
23128396
23143601
23219093
23221041
23229819
23235527
23239884
23243027
23243311
23246965
23250869
23318911
23319821
23324337
23362460
23370280
23376119
23418554
23420876
23442358
23463580
23489692
23521708
23528865
23548208
23574722
23589096
23589370
23626008
23658742
23665236
23687300
23703390
23736768
23774168
23831023
23837456
23867503
23904595
23906991
23924346
23924630
23940783
24070899
24092572
24117128
24163127
24207093
24213852
24220032
24225752
24225756
24228118
24258200
24310252
24316488
24366874
24415949
24418859
24449888
24590290
24594999
24746200

Gene Ontology  (GO ID)

Biological Process

GO:0007569  cell aging
GO:0034644  cellular response to UV
GO:0006338  chromatin remodeling
GO:0060197  cloacal septation
GO:0042771  DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis
GO:0006978  DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0007499  ectoderm and mesoderm interaction
GO:0030326  embryonic limb morphogenesis
GO:0010481  epidermal cell division
GO:0002064  epithelial cell development
GO:0001736  establishment of planar polarity
GO:0048807  female genitalia morphogenesis
GO:0031571  G1/S DNA damage checkpoint
GO:0031069  hair follicle morphogenesis
GO:0006917  induction of apoptosis
GO:0030216  keratinocyte differentiation
GO:0043616  keratinocyte proliferation
GO:0010259  multicellular organismal aging
GO:0043066  negative regulation of apoptosis
GO:0045617  negative regulation of keratinocyte differentiation
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0051402  neuron apoptosis
GO:0007219  Notch signaling pathway
GO:0042475  odontogenesis of dentine-containing tooth
GO:0030859  polarized epithelial cell differentiation
GO:0002053  positive regulation of mesenchymal cell proliferation
GO:0045747  positive regulation of Notch signaling pathway
GO:0045669  positive regulation of osteoblast differentiation
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0060513  prostatic bud formation
GO:0051289  protein homotetramerization
GO:0009954  proximal/distal pattern formation
GO:0043523  regulation of neuron apoptosis
GO:0010332  response to gamma radiation
GO:0010165  response to X-ray
GO:0001501  skeletal system development
GO:0048745  smooth muscle tissue development
GO:0060529  squamous basal epithelial stem cell differentiation involved in prostate gland acinus development
GO:0048485  sympathetic nervous system development
GO:0060157  urinary bladder development

Cellular Component

GO:0000785  chromatin
GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0030425  dendrite
GO:0005794  Golgi apparatus
GO:0000790  nuclear chromatin
GO:0005730  nucleolus
GO:0005654  nucleoplasm
GO:0005634  nucleus
GO:0005667  transcription factor complex

Molecular Function

GO:0003682  chromatin binding
GO:0003684  damaged DNA binding
GO:0003677  DNA binding
GO:0044212  DNA regulatory region binding
GO:0003690  double-stranded DNA binding
GO:0042802  identical protein binding
GO:0046872  metal ion binding
GO:0002039  p53 binding
GO:0005515  protein binding
GO:0043565  sequence-specific DNA binding
GO:0003700  transcription factor activity