actinin, alpha 1

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Synonym

Alpha-actinin cytoskeletal isoform, Alpha-actinin-1, actinin, alpha 1, ACTN1, Non-muscle alpha-actinin-1, FLJ40884

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:154.10

cerebellum:63

brain stem:-

corpus callosum/glia:787.40

pineal gland:148.30

peripheral nerve:153.40

spine:224.60

retina:118.60

eye:229.20

artery/aorta:359.70

vein:66.60

lymphnode:40.40

peripheral blood:164

spleen:113.40

thymus:154.60

bone marrow:767.50

adipose:201.70

bone:281.50

skin:259.20

GeneChip

cerebrum:6.77

cerebellum:6.10

brain stem:6.05

corpus callosum/glia:6.17

pineal gland:-

peripheral nerve:6.70

spine:6.06

retina:-

eye:-

artery/aorta:9.53

vein:8.94

lymphnode:7.30

peripheral blood:-

spleen:6.89

thymus:6.40

bone marrow:8.02

adipose:7.78

bone:-

skin:7.38

CAGE

cerebrum:4.55

cerebellum:-

brain stem:3.50

corpus callosum/glia:3.41

pineal gland:4.36

peripheral nerve:-

spine:4.61

retina:-

eye:-

artery/aorta:7.18

vein:5.29

lymphnode:4.77

peripheral blood:-

spleen:4.98

thymus:3.84

bone marrow:-

adipose:5.08

bone:-

skin:-

RNA-seq

cerebrum:2.83

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:0.00

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:0.00

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:565

placenta:193.10

prostate:259.10

ovary:-

testis:125.50

heart:191.60

muscle:20.10

esophagus:342.80

stomach:148.70

intestine:388.80

colon:381.60

liver/hepato:84.40

lung:288.40

bladder:125.60

kidney:93.60

pituitary:-

thyroid/parathyroid:-

adrenal gland:50.80

pancreas:106.70

breast:455.40

salivary:328.40

GeneChip

uterus:8.36

placenta:6.58

prostate:8.16

ovary:7.85

testis:6.47

heart:7.40

muscle:6.68

esophagus:7.80

stomach:8.23

intestine:7.51

colon:7.77

liver/hepato:7.15

lung:7.22

bladder:-

kidney:6.84

pituitary:6.52

thyroid/parathyroid:6.66

adrenal gland:7.19

pancreas:7.19

breast:8.21

salivary:7.57

CAGE

uterus:5.72

placenta:4.85

prostate:5.86

ovary:5.36

testis:4.46

heart:5.65

muscle:4.01

esophagus:5.92

stomach:-

intestine:4.77

colon:5.63

liver/hepato:4.90

lung:4.86

bladder:6.42

kidney:4.46

pituitary:4.21

thyroid/parathyroid:3.94

adrenal gland:-

pancreas:4.42

breast:5.74

salivary:4.80

RNA-seq

uterus:-

placenta:-

prostate:0.00

ovary:0.00

testis:0.00

heart:0.00

muscle:0.26

esophagus:-

stomach:-

intestine:-

colon:0.00

liver/hepato:0.59

lung:0.12

bladder:-

kidney:0.04

pituitary:-

thyroid/parathyroid:0.41

adrenal gland:0.75

pancreas:-

breast:0.37

salivary:-

IDs

Refseq ID	NM_001130004
Gene ID	87
Unigene ID	Hs.509765
Probe set ID	211160_x_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000072110
GTEx ID	ENSG00000072110

Orthologous Gene

Mouse[3]	NM_134156
Rat[1]	NM_031005

Chromosomal Region

14q24.1 [69,340,860 - 69,446,157]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR002048	Calcium-binding EF-hand
IPR016146	Calponin-homology
IPR001715	Calponin-like actin-binding
IPR018249	EF-HAND 2
IPR018159	Spectrin/alpha-actinin

Gene Ontology (GO ID)

Biological Process

GO:0051764	actin crosslink formation
GO:0051017	actin filament bundle formation
GO:0007596	blood coagulation
GO:0034329	cell junction assembly
GO:0030198	extracellular matrix organization
GO:0048041	focal adhesion formation
GO:0051271	negative regulation of cellular component movement
GO:0030168	platelet activation
GO:0002576	platelet degranulation
GO:0042981	regulation of apoptosis

Cellular Component

GO:0042995	cell projection
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005829	cytosol
GO:0043197	dendritic spine
GO:0005576	extracellular region
GO:0070062	extracellular vesicular exosome
GO:0005916	fascia adherens
GO:0005925	focal adhesion
GO:0005634	nucleus
GO:0005886	plasma membrane
GO:0031093	platelet alpha granule lumen
GO:0031143	pseudopodium
GO:0001726	ruffle
GO:0030018	Z disc

Molecular Function

GO:0051015	actin filament binding
GO:0005509	calcium ion binding
GO:0005178	integrin binding
GO:0005515	protein binding
GO:0019904	protein domain specific binding
GO:0017166	vinculin binding

actinin, alpha 1

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function