receptor-interacting serine-threonine kinase 2

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Synonym

RIP2, GIG30, Receptor-interacting protein 2, receptor-interacting serine-threonine kinase 2, RIP-like-interacting CLARP kinase, CCK, CARD-containing IL-1 beta ICE-kinase, RICK, RIP-2, CARDIAK, RIPK2, UNQ277/PRO314/PRO34092, CARD3

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:27.30 cerebellum:- brain stem:- corpus callosum/glia:29.20 pineal gland:- peripheral nerve:- spine:- retina:- eye:11.80 artery/aorta:179.90 vein:- lymphnode:50.60 peripheral blood:- spleen:37.80 thymus:25.80 bone marrow:- adipose:- bone:12.80 skin:9.60
GeneChip cerebrum:3.21 cerebellum:3 brain stem:3.36 corpus callosum/glia:3.49 pineal gland:- peripheral nerve:3.26 spine:3.75 retina:- eye:- artery/aorta:3.11 vein:3.22 lymphnode:3.16 peripheral blood:- spleen:3.17 thymus:3.02 bone marrow:3.12 adipose:3.26 bone:- skin:3.02
CAGE cerebrum:2.64 cerebellum:- brain stem:2.90 corpus callosum/glia:3.04 pineal gland:2.21 peripheral nerve:- spine:3.35 retina:- eye:- artery/aorta:2.97 vein:2.89 lymphnode:3.01 peripheral blood:- spleen:3.27 thymus:2.25 bone marrow:- adipose:3.18 bone:- skin:-
RNA-seq cerebrum:2.54 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.83 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:2.75 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:27.30 placenta:69.20 prostate:33.80 ovary:37.30 testis:21.60 heart:25.50 muscle:- esophagus:- stomach:169.90 intestine:32.40 colon:25.40     liver/hepato:-        lung:44    bladder:125.60 kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:8.90 breast:55.80 salivary:-
GeneChip uterus:3.26 placenta:3.49 prostate:3.35 ovary:3.15 testis:2.95 heart:3.29 muscle:3.12 esophagus:3.01 stomach:3.14 intestine:3.07 colon:3.13 liver/hepato:3.25 lung:3.20 bladder:- kidney:3.13 pituitary:3.08 thyroid/parathyroid:3 adrenal gland:3.05 pancreas:3.51 breast:3.11 salivary:3.25
CAGE uterus:2.92 placenta:3.55 prostate:2.87 ovary:2.85 testis:2.37 heart:2.95 muscle:1.67 esophagus:2.82 stomach:- intestine:2.46 colon:2.63     liver/hepato:2.78    lung:3.31 bladder:3.33 kidney:2.73 pituitary:2.68 thyroid/parathyroid:2.76 adrenal gland:- pancreas:2.48 breast:2.99 salivary:2.80
RNA-seq uterus:- placenta:- prostate:2.75 ovary:2.75 testis:2.67 heart:2.07 muscle:0.98 esophagus:- stomach:- intestine:- colon:2.74     liver/hepato:1.63        lung:3.97    bladder:- kidney:2.24 pituitary:- thyroid/parathyroid:2.32 adrenal gland:2.68 pancreas:- breast:2.55 salivary:-

Gene Information

IDs

Refseq ID NM_003821
Gene ID 8767
Unigene ID Hs.103755
Probe set ID 209544_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000104312
GTEx ID ENSG00000104312

Orthologous Gene

Mouse[2]  NM_138952
Rat [0]  

Chromosomal Region

8q21.3  [90,769,975  -  90,803,291]

Gene Family (Interpro ID)

IPR001315  Caspase Recruitment
IPR011029  DEATH-like
IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

9575181
9642260
9705938
10224040
10329646
10559258
10719670
10880512
11087742
11432859
11487608
11536016
11894097
11894098
12138198
12459189
12477932
12755636
12761501
12775719
12938929
12975309
14638696
15276183
15489334
15620648
15657077
15691841
15761153
16189514
16344560
16354923
16418290
16421571
16492792
16498402
16517750
16582588
16824733
16920334
16997282
17054981
17075290
17192257
17348859
17353931
17355968
17468049
17851464
17947236
17965022
18029348
18079694
18329614
18342009
18359207
18426885
18566542
19121870
19336552
19337385
19406482
19464198
19573080
19592251
19667203
19693652
19721713
19773279
19911254
20018961
20025869
20125193
20645315
20800603
20949042
21048031
21097508
21123652
21139048
21757725
21862576
21887730
21903422
21906983
21931591
22075569
22484241
22504414
22547678
22607974
22615316
22665475
22685397
22815893
22828789
22993319
23128233
23300079
23333941
23437331
23455924
23818254
23892723
24015287
24250222
24366254

Gene Ontology  (GO ID)

Biological Process

GO:0000187  activation of MAPK activity
GO:0002250  adaptive immune response
GO:0006915  apoptosis
GO:0071223  cellular response to lipoteichoic acid
GO:0071224  cellular response to peptidoglycan
GO:0050830  defense response to Gram-positive bacterium
GO:0007249  I-kappaB kinase/NF-kappaB cascade
GO:0006954  inflammatory response
GO:0045087  innate immune response
GO:0007254  JNK cascade
GO:0031663  lipopolysaccharide-mediated signaling pathway
GO:0002755  MyD88-dependent toll-like receptor signaling pathway
GO:0002756  MyD88-independent toll-like receptor signaling pathway
GO:0043066  negative regulation of apoptosis
GO:0048011  nerve growth factor receptor signaling pathway
GO:0070427  nucleotide-binding oligomerization domain containing 1 signaling pathway
GO:0070431  nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0070423  nucleotide-binding oligomerization domain containing signaling pathway
GO:0046641  positive regulation of alpha-beta T cell proliferation
GO:0043065  positive regulation of apoptosis
GO:0032722  positive regulation of chemokine production
GO:0001961  positive regulation of cytokine-mediated signaling pathway
GO:0070374  positive regulation of ERK1 and ERK2 cascade
GO:0043123  positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0033091  positive regulation of immature T cell proliferation
GO:0032727  positive regulation of interferon-alpha production
GO:0032728  positive regulation of interferon-beta production
GO:0032729  positive regulation of interferon-gamma production
GO:0032735  positive regulation of interleukin-12 production
GO:0032743  positive regulation of interleukin-2 production
GO:0032755  positive regulation of interleukin-6 production
GO:0046330  positive regulation of JNK cascade
GO:0051092  positive regulation of NF-kappaB transcription factor activity
GO:0031398  positive regulation of protein ubiquitination
GO:0045627  positive regulation of T-helper 1 cell differentiation
GO:0002827  positive regulation of T-helper 1 type immune response
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0032760  positive regulation of tumor necrosis factor production
GO:0043330  response to exogenous dsRNA
GO:0070555  response to interleukin-1
GO:0070671  response to interleukin-12
GO:0070673  response to interleukin-18
GO:0007165  signal transduction
GO:0051403  stress-activated MAPK cascade
GO:0042098  T cell proliferation
GO:0050852  T cell receptor signaling pathway
GO:0034166  toll-like receptor 10 signaling pathway
GO:0034134  toll-like receptor 2 signaling pathway
GO:0034138  toll-like receptor 3 signaling pathway
GO:0034142  toll-like receptor 4 signaling pathway
GO:0034146  toll-like receptor 5 signaling pathway
GO:0034162  toll-like receptor 9 signaling pathway
GO:0002224  toll-like receptor signaling pathway

Cellular Component

GO:0005737  cytoplasm
GO:0005829  cytosol

Molecular Function

GO:0005524  ATP binding
GO:0050700  CARD domain binding
GO:0030274  LIM domain binding
GO:0004715  non-membrane spanning protein tyrosine kinase activity
GO:0005515  protein binding
GO:0042803  protein homodimerization activity
GO:0004674  protein serine/threonine kinase activity
GO:0004871  signal transducer activity