sphingosine kinase 1

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Synonym

sphingosine kinase 1, Sphingosine kinase 1, SPHK1, SPK 1, SPHK, SK 1

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

nodata

GeneChip

cerebrum:6.38

cerebellum:6.24

brain stem:6.54

corpus callosum/glia:6.32

pineal gland:-

peripheral nerve:7.01

spine:6.42

retina:-

eye:-

artery/aorta:7.21

vein:7.10

lymphnode:7.05

peripheral blood:-

spleen:6.18

thymus:6.31

bone marrow:6.84

adipose:6.90

bone:-

skin:6.94

CAGE

cerebrum:0.85

cerebellum:-

brain stem:1.27

corpus callosum/glia:1.06

pineal gland:1.15

peripheral nerve:-

spine:0.76

retina:-

eye:-

artery/aorta:1.97

vein:1.61

lymphnode:1.85

peripheral blood:-

spleen:0.71

thymus:0.94

bone marrow:-

adipose:1.37

bone:-

skin:-

RNA-seq

cerebrum:0.21

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:0.74

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:0.00

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

nodata

GeneChip

uterus:6.42

placenta:6.07

prostate:6.06

ovary:6.21

testis:6.56

heart:6.62

muscle:6.17

esophagus:7.43

stomach:6.39

intestine:6.58

colon:6.61

liver/hepato:6.49

lung:7.13

bladder:-

kidney:6.28

pituitary:6.62

thyroid/parathyroid:6.80

adrenal gland:6.55

pancreas:6.38

breast:7.04

salivary:6.74

CAGE

uterus:0.86

placenta:1.43

prostate:1.03

ovary:1.18

testis:0.99

heart:1.66

muscle:0.68

esophagus:1.48

stomach:-

intestine:1.24

colon:0.90

liver/hepato:0.14

lung:1.62

bladder:1.18

kidney:0.62

pituitary:0

thyroid/parathyroid:1.60

adrenal gland:-

pancreas:1.59

breast:2.27

salivary:0.83

RNA-seq

uterus:-

placenta:-

prostate:0.00

ovary:0.00

testis:0.33

heart:0.00

muscle:0.00

esophagus:-

stomach:-

intestine:-

colon:0.09

liver/hepato:0.00

lung:1.47

bladder:-

kidney:0.00

pituitary:-

thyroid/parathyroid:0.33

adrenal gland:0.89

pancreas:-

breast:0.68

salivary:-

IDs

Refseq ID	NM_021972
Gene ID	8877
Unigene ID	-
Probe set ID	219257_s_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000176170
GTEx ID	ENSG00000176170

Orthologous Gene

Mouse[2]	NM_001172472, NM_001172473, NM_001172475, NM_011451, NM_025367
Rat[1]	NM_133386, NM_001172473, NM_001172475, NM_011451, NM_025367

Chromosomal Region

17q25.1 [74,372,742 - 74,383,941]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

Gene Ontology (GO ID)

Biological Process

GO:0051084	'de novo' posttranslational protein folding
GO:0007205	activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway
GO:0001568	blood vessel development
GO:0007420	brain development
GO:0019722	calcium-mediated signaling
GO:0044267	cellular protein metabolic process
GO:0006954	inflammatory response
GO:0043066	negative regulation of apoptosis
GO:0045766	positive regulation of angiogenesis
GO:0030307	positive regulation of cell growth
GO:0030335	positive regulation of cell migration
GO:0048146	positive regulation of fibroblast proliferation
GO:0045931	positive regulation of mitotic cell cycle
GO:0042346	positive regulation of NF-kappaB import into nucleus
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0031398	positive regulation of protein ubiquitination
GO:0045987	positive regulation of smooth muscle contraction
GO:0006457	protein folding
GO:0032651	regulation of interleukin-1 beta production
GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway
GO:0007165	signal transduction
GO:0046521	sphingoid catabolic process
GO:0030148	sphingolipid biosynthetic process
GO:0006665	sphingolipid metabolic process
GO:0006670	sphingosine metabolic process

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005634	nucleus
GO:0005886	plasma membrane

Molecular Function

GO:0005524	ATP binding
GO:0005516	calmodulin binding
GO:0017050	D-erythro-sphingosine kinase activity
GO:0004143	diacylglycerol kinase activity
GO:0003677	DNA binding
GO:0000287	magnesium ion binding
GO:0005515	protein binding
GO:0051721	protein phosphatase 2A binding
GO:0008481	sphinganine kinase activity

sphingosine kinase 1

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function