sphingosine kinase 1

jump to detail

Synonym

sphingosine kinase 1, Sphingosine kinase 1, SPHK1, SPK 1, SPHK, SK 1

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST nodata
GeneChip cerebrum:6.38 cerebellum:6.24 brain stem:6.54 corpus callosum/glia:6.32 pineal gland:- peripheral nerve:7.01 spine:6.42 retina:- eye:- artery/aorta:7.21 vein:7.10 lymphnode:7.05 peripheral blood:- spleen:6.18 thymus:6.31 bone marrow:6.84 adipose:6.90 bone:- skin:6.94
CAGE cerebrum:0.85 cerebellum:- brain stem:1.27 corpus callosum/glia:1.06 pineal gland:1.15 peripheral nerve:- spine:0.76 retina:- eye:- artery/aorta:1.97 vein:1.61 lymphnode:1.85 peripheral blood:- spleen:0.71 thymus:0.94 bone marrow:- adipose:1.37 bone:- skin:-
RNA-seq cerebrum:0.08 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.57 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.40 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST nodata
GeneChip uterus:6.42 placenta:6.07 prostate:6.06 ovary:6.21 testis:6.56 heart:6.62 muscle:6.17 esophagus:7.43 stomach:6.39 intestine:6.58 colon:6.61 liver/hepato:6.49 lung:7.13 bladder:- kidney:6.28 pituitary:6.62 thyroid/parathyroid:6.80 adrenal gland:6.55 pancreas:6.38 breast:7.04 salivary:6.74
CAGE uterus:0.86 placenta:1.43 prostate:1.03 ovary:1.18 testis:0.99 heart:1.66 muscle:0.68 esophagus:1.48 stomach:- intestine:1.24 colon:0.90     liver/hepato:0.14    lung:1.62 bladder:1.18 kidney:0.62 pituitary:0 thyroid/parathyroid:1.60 adrenal gland:- pancreas:1.59 breast:2.27 salivary:0.83
RNA-seq uterus:- placenta:- prostate:0.23 ovary:0 testis:0.32 heart:0.03 muscle:0.06 esophagus:- stomach:- intestine:- colon:0.33     liver/hepato:0        lung:1.64    bladder:- kidney:0.03 pituitary:- thyroid/parathyroid:0.36 adrenal gland:0.74 pancreas:- breast:0.56 salivary:-

IDs

Refseq ID NM_182965
Gene ID 8877
Unigene ID -
Probe set ID 219257_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000176170
GTEx ID ENSG00000176170

Orthologous Gene

Mouse[2]  NM_001172472, NM_001172473, NM_001172475, NM_011451, NM_025367
Rat[1]  NM_133386, NM_001172473, NM_001172475, NM_011451, NM_025367

Chromosomal Region

Gene Family (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

Gene Ontology  (GO ID)

Biological Process

GO:0051084  'de novo' posttranslational protein folding
GO:0007205  activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway
GO:0001568  blood vessel development
GO:0007420  brain development
GO:0019722  calcium-mediated signaling
GO:0044267  cellular protein metabolic process
GO:0006954  inflammatory response
GO:0043066  negative regulation of apoptosis
GO:0045766  positive regulation of angiogenesis
GO:0030307  positive regulation of cell growth
GO:0030335  positive regulation of cell migration
GO:0048146  positive regulation of fibroblast proliferation
GO:0045931  positive regulation of mitotic cell cycle
GO:0042346  positive regulation of NF-kappaB import into nucleus
GO:0051092  positive regulation of NF-kappaB transcription factor activity
GO:0031398  positive regulation of protein ubiquitination
GO:0045987  positive regulation of smooth muscle contraction
GO:0006457  protein folding
GO:0032651  regulation of interleukin-1 beta production
GO:0010803  regulation of tumor necrosis factor-mediated signaling pathway
GO:0007165  signal transduction
GO:0046521  sphingoid catabolic process
GO:0030148  sphingolipid biosynthetic process
GO:0006665  sphingolipid metabolic process
GO:0006670  sphingosine metabolic process

Cellular Component

GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0005634  nucleus
GO:0005886  plasma membrane

Molecular Function

GO:0005524  ATP binding
GO:0005516  calmodulin binding
GO:0017050  D-erythro-sphingosine kinase activity
GO:0004143  diacylglycerol kinase activity
GO:0003677  DNA binding
GO:0000287  magnesium ion binding
GO:0005515  protein binding
GO:0051721  protein phosphatase 2A binding
GO:0008481  sphinganine kinase activity