sequestosome 1

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Synonym

Sequestosome-1, ORCA, A170, OSIL, Paget disease of bone 3, SQSTM1, Ubiquitin-binding protein p62, EBI3-associated protein of 60 kDa, sequestosome 1, p62B, oxidative stress induced like, ZIP3, PDB3, EBIAP

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:275 cerebellum:503.80 brain stem:- corpus callosum/glia:291.60 pineal gland:148.30 peripheral nerve:368.10 spine:449.20 retina:- eye:634.70 artery/aorta:269.80 vein:799.80 lymphnode:131.40 peripheral blood:783.40 spleen:453.80 thymus:219 bone marrow:944.70 adipose:726 bone:499 skin:360
GeneChip cerebrum:8.26 cerebellum:8.59 brain stem:8.39 corpus callosum/glia:8.47 pineal gland:- peripheral nerve:8.72 spine:8.49 retina:- eye:- artery/aorta:8.87 vein:8.86 lymphnode:8.59 peripheral blood:- spleen:8.47 thymus:8.03 bone marrow:7.66 adipose:9.01 bone:- skin:8.50
CAGE cerebrum:5.06 cerebellum:- brain stem:5.07 corpus callosum/glia:5.29 pineal gland:5.14 peripheral nerve:- spine:5.22 retina:- eye:- artery/aorta:6.06 vein:5.73 lymphnode:5.39 peripheral blood:- spleen:5.24 thymus:4.97 bone marrow:- adipose:6.09 bone:- skin:-
RNA-seq cerebrum:3.78 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:6.11 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:6.70 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:446.50 placenta:750.50 prostate:360.50 ovary:149.10 testis:216.30 heart:178.80 muscle:361.60 esophagus:342.80 stomach:169.90 intestine:453.60 colon:305.30     liver/hepato:358.90        lung:366.60    bladder:1256.10 kidney:259.90 pituitary:116 thyroid/parathyroid:3766.20 adrenal gland:1218.90 pancreas:569 breast:529.70 salivary:656.80
GeneChip uterus:8.77 placenta:9.93 prostate:8.82 ovary:8.87 testis:7.76 heart:8.81 muscle:9.79 esophagus:8.80 stomach:8.45 intestine:8.52 colon:8.32 liver/hepato:8.61 lung:8.75 bladder:- kidney:8.47 pituitary:8.57 thyroid/parathyroid:9.47 adrenal gland:9.20 pancreas:8.03 breast:8.97 salivary:8.67
CAGE uterus:5.58 placenta:6.38 prostate:5.84 ovary:5.67 testis:5.10 heart:6.04 muscle:6.54 esophagus:5.64 stomach:- intestine:5.28 colon:5.56     liver/hepato:5.91    lung:5.91 bladder:6.06 kidney:5.67 pituitary:4.90 thyroid/parathyroid:6.22 adrenal gland:- pancreas:5.63 breast:6.36 salivary:5.71
RNA-seq uterus:- placenta:- prostate:7.14 ovary:4.79 testis:4.71 heart:5.66 muscle:8.66 esophagus:- stomach:- intestine:- colon:6.04     liver/hepato:5.75        lung:6.42    bladder:- kidney:6.19 pituitary:- thyroid/parathyroid:7.35 adrenal gland:5.45 pancreas:- breast:6.54 salivary:-

IDs

Refseq ID NM_003900
Gene ID 8878
Unigene ID Hs.437277
Probe set ID 201471_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000161011
GTEx ID ENSG00000161011

Orthologous Gene

Mouse[1]  NM_011018
Rat[1]  NM_175843

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed  (Pubmed ID)

8551575
8618896
8650207
8702753
8910285
9184228
9252186
9566925
9762895
10022904
10356400
10362795
10708586
10747026
10776788
11244088
11447312
11473345
11563677
11755531
11786419
11852044
11981755
11992264
12034707
12242277
12374763
12431995
12471037
12477932
12700667
12727313
12787561
12813044
12857745
12857950
12869526
12887891
14584883
14676191
14692700
14702039
14702098
15125799
15143057
15146436
15158159
15164150
15176995
15207768
15340068
15489334
15493999
15592455
15647816
15721744
15761153
15765181
15802564
15840729
15870274
15911346
15953362
16011831
16079148
16083285
16129434
16159877
16169070
16189514
16196087
16252010
16286508
16335966
16344560
16405664
16565220
16574459
16630834
16691492
16751776
16793543
16820172
16861740
16874300
16964243
16997282
17052185
17065558
17081983
17120186
17187080
17203973
17229007
17237936
17314511
17580304
17685470
17898222
17931355
17932931
18083104
18083707
18174161
18296712
18379439
18379713
18442140
18457658
18543015
18584184
18624398
18653543
18776740
18781797
18984666
18992722
19004011
19010391
19013454
19016598
19020788
19049332
19056867
19067022
19071211
19074260
19197142
19201866
19229298
19250911
19257822
19282458
19285159
19398892
19427028
19481605
19557423
19589897
19615732
19780870
19812211
19816510
19822672
19850743
19850933
19903815
19931284
20010802
20018885
20061786
20061800
20098416
20103647
20168092
20200946
20204693
20230821
20357094
20360068
20378532
20379614
20417604
20421418
20452972
20495340
20499339
20562859
20573959
20600853
20604804
20639865
20639871
20706999
20711182
20808283
20814791
20837465
20890124
20971078
20974803
20979579
21045561
21062285
21073987
21079414
21118398
21139048
21149568
21160040
21173155
21187718
21195346
21220506
21325881
21371883
21412052
21460636
21482715
21517082
21536669
21544590
21555518
21606687
21617041
21628417
21628531
21646350
21691068
21726808
21735147
21771882
21876553
21890473
21900206
21903097
21906983
21923101
21931693
21935636
21949121
21959292
21963094
21981924
21987572
21988832
22017874
22053931
22084127
22098537
22118674
22178386
22190034
22190037
22286270
22296116
22320446
22322858
22411133
22434781
22491873
22505724
22525272
22565157
22674379
22714671
22728060
22792322
22797925
22835604
22841931
22863883
22939629
22941224
22952826
22963397
22972638
22992334
23000965
23017601
23023376
23117207
23239879
23242280
23266528
23274085
23300799
23303844
23314748
23333919
23345396
23398456
23402259
23417734
23434281
23437331
23455922
23459205
23503661
23564079
23637164
23649778
23681079
23686137
23752596
23824909
23911927
23989536
24011591
24023838
24042580
24065390
24086340
24086678
24100292
24121507
24122957
24128730
24162737
24220190
24270048
24270664
24322982
24332042
24413169
24440703
24582747
24616100
24618016
24619419
24642144
24654937
24664425
24667411
24769000
24769734
24778252

Gene Ontology  (GO ID)

Biological Process

GO:0006914  autophagy
GO:0030154  cell differentiation
GO:0016197  endosome transport
GO:0016236  macroautophagy
GO:0043066  negative regulation of apoptosis
GO:0048011  nerve growth factor receptor signaling pathway
GO:0043065  positive regulation of apoptosis
GO:0001934  positive regulation of protein amino acid phosphorylation
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0051291  protein heterooligomerization
GO:0008104  protein localization
GO:0043122  regulation of I-kappaB kinase/NF-kappaB cascade
GO:0046578  regulation of Ras protein signal transduction
GO:0006950  response to stress
GO:0006511  ubiquitin-dependent protein catabolic process

Cellular Component

GO:0016235  aggresome
GO:0005776  autophagic vacuole
GO:0000932  cytoplasmic mRNA processing body
GO:0031410  cytoplasmic vesicle
GO:0005829  cytosol
GO:0005783  endoplasmic reticulum
GO:0005770  late endosome
GO:0005764  lysosome
GO:0005654  nucleoplasm
GO:0000407  pre-autophagosomal structure

Molecular Function

GO:0042802  identical protein binding
GO:0070530  K63-linked polyubiquitin binding
GO:0005515  protein binding
GO:0042803  protein homodimerization activity
GO:0019901  protein kinase binding
GO:0005080  protein kinase C binding
GO:0004674  protein serine/threonine kinase activity
GO:0030971  receptor tyrosine kinase binding
GO:0042169  SH2 domain binding
GO:0043130  ubiquitin binding
GO:0008270  zinc ion binding