ubiquitin specific peptidase 13 (isopeptidase T-3)

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Synonym

ubiquitin specific peptidase 13 (isopeptidase T-3), ISOT-3, USP13, IsoT-3, ISOT3, Ubiquitin carboxyl-terminal hydrolase 13, Ubiquitin-specific-processing protease 13, Deubiquitinating enzyme 13, Isopeptidase T-3, Ubiquitin thioesterase 13

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:2.40 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:30.70 spine:- retina:- eye:5.90 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:40.30 bone:38.40 skin:24
GeneChip cerebrum:7.03 cerebellum:6.75 brain stem:7 corpus callosum/glia:7.01 pineal gland:- peripheral nerve:7.29 spine:6.87 retina:- eye:- artery/aorta:7.24 vein:7.86 lymphnode:7.04 peripheral blood:- spleen:6.73 thymus:6.48 bone marrow:6.21 adipose:7.42 bone:- skin:7.04
CAGE cerebrum:2.55 cerebellum:- brain stem:2.56 corpus callosum/glia:3.15 pineal gland:4.17 peripheral nerve:- spine:2.46 retina:- eye:- artery/aorta:2.56 vein:3.12 lymphnode:2.75 peripheral blood:- spleen:2.23 thymus:2.23 bone marrow:- adipose:3.47 bone:- skin:-
RNA-seq cerebrum:2.30 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:1.46 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:4.60 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:3.60 prostate:45.10 ovary:- testis:26 heart:12.80 muscle:180.80 esophagus:- stomach:- intestine:- colon:-     liver/hepato:31.70        lung:14.70    bladder:- kidney:- pituitary:- thyroid/parathyroid:163.70 adrenal gland:50.80 pancreas:- breast:27.90 salivary:-
GeneChip uterus:7.26 placenta:6.09 prostate:7.23 ovary:7.39 testis:7.85 heart:8.95 muscle:11.12 esophagus:8.09 stomach:6.76 intestine:6.96 colon:6.64 liver/hepato:7.14 lung:7 bladder:- kidney:7.06 pituitary:8.39 thyroid/parathyroid:7.87 adrenal gland:9.15 pancreas:6.56 breast:7.11 salivary:7.49
CAGE uterus:2.89 placenta:1.99 prostate:2.64 ovary:2.99 testis:3.40 heart:4.52 muscle:5.98 esophagus:2.55 stomach:- intestine:1.82 colon:2.35     liver/hepato:2.14    lung:3.48 bladder:2.76 kidney:2.11 pituitary:3.63 thyroid/parathyroid:3.19 adrenal gland:- pancreas:2.60 breast:2.91 salivary:2.93
RNA-seq uterus:- placenta:- prostate:1.92 ovary:2.72 testis:2.87 heart:5.36 muscle:6.94 esophagus:- stomach:- intestine:- colon:1.83     liver/hepato:1.59        lung:1.14    bladder:- kidney:1.49 pituitary:- thyroid/parathyroid:4.45 adrenal gland:1.84 pancreas:- breast:2.86 salivary:-

Gene Information

IDs

Refseq ID NM_003940
Gene ID 8975
Unigene ID Hs.175322
Probe set ID 205356_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000058056
GTEx ID ENSG00000058056

Orthologous Gene

Mouse[1]  NM_001013024
Rat[1]  NM_001107665

Chromosomal Region

3q26.33  [179,370,543  -  179,507,189]

Gene Family (Interpro ID)

IPR000449  Ubiquitin-associated/translation elongation factor EF1B, N-terminal
IPR015940  Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote

Link to Pubmed  (Pubmed ID)

9827704
9841226
11076863
11927605
12477932
12838346
14702039
15231748
15489336
16169070
16381901
17148452
18029348
19013454
19615732
20379614
20972266
21139048
21571647
21659512
21811243
21890473
21906983
21962518
21963094
21987572
22053931
22216260
22505724
22939629
23000965
23314748
23940278
24270891
24816145

Gene Ontology  (GO ID)

Biological Process

GO:0006914  autophagy
GO:0008283  cell proliferation
GO:0030318  melanocyte differentiation
GO:0070536  protein K63-linked deubiquitination
GO:0050821  protein stabilization
GO:0010506  regulation of autophagy
GO:0006355  regulation of transcription, DNA-dependent
GO:0006511  ubiquitin-dependent protein catabolic process

Molecular Function

GO:0004197  cysteine-type endopeptidase activity
GO:0008242  omega peptidase activity
GO:0005515  protein binding
GO:0043130  ubiquitin binding
GO:0031625  ubiquitin protein ligase binding
GO:0004221  ubiquitin thiolesterase activity
GO:0004843  ubiquitin-specific protease activity
GO:0008270  zinc ion binding