NFS1 nitrogen fixation 1 homolog (S. cerevisiae)

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Synonym

IscS, NifS, Cysteine desulfurase, mitochondrial precursor, NIFS, HUSSY-08, NFS1 nitrogen fixation 1 homolog (S. cerevisiae), NFS1

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:135.10 cerebellum:302.30 brain stem:- corpus callosum/glia:233.30 pineal gland:148.30 peripheral nerve:30.70 spine:- retina:- eye:64.60 artery/aorta:149.90 vein:- lymphnode:30.30 peripheral blood:164 spleen:75.60 thymus:103.10 bone marrow:- adipose:80.70 bone:51.20 skin:67.20
GeneChip cerebrum:6.61 cerebellum:6.39 brain stem:6.61 corpus callosum/glia:6.34 pineal gland:- peripheral nerve:6.74 spine:6.53 retina:- eye:- artery/aorta:6.09 vein:5.92 lymphnode:6.32 peripheral blood:- spleen:6.25 thymus:6.02 bone marrow:6.16 adipose:6.33 bone:- skin:6.18
CAGE cerebrum:3.36 cerebellum:- brain stem:3.23 corpus callosum/glia:3.07 pineal gland:3.19 peripheral nerve:- spine:3.12 retina:- eye:- artery/aorta:2.74 vein:2.78 lymphnode:2.49 peripheral blood:- spleen:2.14 thymus:2.17 bone marrow:- adipose:2.48 bone:- skin:-
RNA-seq cerebrum:3.51 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.44 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:2.55 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:54.70 placenta:58.30 prostate:56.30 ovary:74.50 testis:60.60 heart:178.80 muscle:40.20 esophagus:- stomach:127.50 intestine:518.40 colon:42.40     liver/hepato:42.20        lung:34.20    bladder:125.60 kidney:104 pituitary:- thyroid/parathyroid:- adrenal gland:711 pancreas:- breast:83.60 salivary:-
GeneChip uterus:6.11 placenta:6.05 prostate:6.38 ovary:6.34 testis:7.39 heart:6.43 muscle:6.69 esophagus:6.29 stomach:6.29 intestine:6.36 colon:6.53 liver/hepato:6.92 lung:6.01 bladder:- kidney:7.36 pituitary:6.62 thyroid/parathyroid:6.47 adrenal gland:7.09 pancreas:5.81 breast:6.59 salivary:6.47
CAGE uterus:2.64 placenta:2.53 prostate:2.64 ovary:2.71 testis:3.75 heart:3.05 muscle:2.97 esophagus:2.82 stomach:- intestine:2.70 colon:2.99     liver/hepato:3.18    lung:2.61 bladder:2.55 kidney:3.11 pituitary:3.13 thyroid/parathyroid:2.84 adrenal gland:- pancreas:3.06 breast:2.83 salivary:3.21
RNA-seq uterus:- placenta:- prostate:3.06 ovary:3.10 testis:3.85 heart:3.30 muscle:2.78 esophagus:- stomach:- intestine:- colon:2.74     liver/hepato:3.35        lung:1.10    bladder:- kidney:3.89 pituitary:- thyroid/parathyroid:2.84 adrenal gland:2.08 pancreas:- breast:2.88 salivary:-

Gene Information

IDs

Refseq ID NM_021100
Gene ID 9054
Unigene ID Hs.194692
Probe set ID 218455_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000244005
GTEx ID ENSG00000244005

Orthologous Gene

Mouse[2]  NM_010911
Rat[1]  NM_053462

Chromosomal Region

20q11.22  [34,220,262  -  34,287,281]

Gene Family (Interpro ID)

IPR000192  Aminotransferase, class V/Cysteine desulfurase
IPR010240  Cysteine desulfurase
IPR016454  Cysteine desulfurase, NifS

Link to Pubmed  (Pubmed ID)

8125298
9885568
11060020
11124703
11256614
11780052
12477932
14702039
15489334
16344560
16527810
16847322
17207965
17474147
17567994
18650437
19720832
20877624
21081666
21906983
21963094
22689995
23593335
23940031
24217246

Gene Ontology  (GO ID)

Biological Process

GO:0006534  cysteine metabolic process
GO:0018283  iron incorporation into metallo-sulfur cluster
GO:0006777  Mo-molybdopterin cofactor biosynthetic process
GO:0032324  molybdopterin cofactor biosynthetic process
GO:0006461  protein complex assembly
GO:0000096  sulfur amino acid metabolic process
GO:0006766  vitamin metabolic process
GO:0006767  water-soluble vitamin metabolic process

Cellular Component

GO:0005829  cytosol
GO:0005759  mitochondrial matrix
GO:0005739  mitochondrion
GO:0005634  nucleus

Molecular Function

GO:0031071  cysteine desulfurase activity
GO:0005515  protein binding
GO:0042803  protein homodimerization activity
GO:0030170  pyridoxal phosphate binding