PRP4 pre-mRNA processing factor 4 homolog (yeast)

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Synonym

HPRP4P, Prp4p, U4/U6 small nuclear ribonucleoprotein Prp4, PRP4, HPRP4, PRP4 pre-mRNA processing factor 4 homolog (yeast), U4/U6 snRNP 60 kDa protein, WD splicing factor Prp4, PRPF4, hPrp4

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:13 cerebellum:12.60 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:30.70 spine:- retina:118.60 eye:23.50 artery/aorta:60 vein:133.30 lymphnode:40.40 peripheral blood:72.90 spleen:- thymus:25.80 bone marrow:59 adipose:80.70 bone:12.80 skin:96
GeneChip cerebrum:6.58 cerebellum:6.64 brain stem:6.64 corpus callosum/glia:6.39 pineal gland:- peripheral nerve:6.81 spine:6.54 retina:- eye:- artery/aorta:6.73 vein:6.37 lymphnode:6.92 peripheral blood:- spleen:6.84 thymus:7.16 bone marrow:6.94 adipose:6.70 bone:- skin:7.06
CAGE cerebrum:3.02 cerebellum:- brain stem:2.63 corpus callosum/glia:2.77 pineal gland:3.56 peripheral nerve:- spine:3.01 retina:- eye:- artery/aorta:2.86 vein:2.90 lymphnode:3.02 peripheral blood:- spleen:2.95 thymus:2.98 bone marrow:- adipose:2.75 bone:- skin:-
RNA-seq cerebrum:0.02 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.54 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.00 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:18.20 prostate:56.30 ovary:- testis:26 heart:38.30 muscle:- esophagus:- stomach:- intestine:- colon:25.40     liver/hepato:21.10        lung:9.80    bladder:- kidney:31.20 pituitary:695.90 thyroid/parathyroid:- adrenal gland:- pancreas:44.50 breast:37.20 salivary:-
GeneChip uterus:7.07 placenta:6.67 prostate:7.59 ovary:7.22 testis:7.28 heart:6.64 muscle:6.90 esophagus:6.97 stomach:6.67 intestine:6.81 colon:6.70 liver/hepato:6.65 lung:6.68 bladder:- kidney:6.97 pituitary:6.77 thyroid/parathyroid:6.80 adrenal gland:6.89 pancreas:6.76 breast:7.19 salivary:7.04
CAGE uterus:2.90 placenta:2.83 prostate:2.89 ovary:2.97 testis:2.89 heart:2.99 muscle:3.14 esophagus:2.77 stomach:- intestine:2.55 colon:2.64     liver/hepato:2.81    lung:2.77 bladder:2.95 kidney:2.80 pituitary:3.04 thyroid/parathyroid:2.64 adrenal gland:- pancreas:3.06 breast:3.12 salivary:3.01
RNA-seq uterus:- placenta:- prostate:0.97 ovary:0.00 testis:1.91 heart:1.19 muscle:1.18 esophagus:- stomach:- intestine:- colon:0.36     liver/hepato:1.34        lung:0.00    bladder:- kidney:0.00 pituitary:- thyroid/parathyroid:1.03 adrenal gland:0.00 pancreas:- breast:0.40 salivary:-

Gene Information

IDs

Refseq ID NM_004697
Gene ID 9128
Unigene ID Hs.530284
Probe set ID 209161_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000136875
GTEx ID ENSG00000136875

Orthologous Gene

Mouse[1]  NM_027297
Rat[1]  NM_001106659

Chromosomal Region

9q32  [116,037,623  -  116,055,466]

Gene Family (Interpro ID)

IPR020472  G-protein beta WD-40 repeat, region
IPR014906  Pre-mRNA processing factor 4 (PRP4) like
IPR003648  Splicing factor motif
IPR001680  WD40 repeat
IPR019782  WD40 repeat 2
IPR019781  WD40 repeat, subgroup
IPR011046  WD40 repeat-like-containing domain
IPR017986  WD40-repeat-containing domain
IPR015943  WD40/YVTN repeat-like-containing domain

Link to Pubmed  (Pubmed ID)

8125298
9000057
9257651
9328476
9404889
9521884
9570313
11350945
11418604
11971898
11971955
12226669
12477932
12875835
12907720
15257298
15452143
15452250
15489334
15635413
15761153
16055720
16169070
16196087
16226712
16344560
16723661
17513757
17620599
17643375
17998396
18029348
18687998
19615732
19738201
20360068
21139048
21145461
21832049
21890473
22365833
22446626
22863883
22939629
23349634
23602568
23667531
24003220
24654937

Gene Ontology  (GO ID)

Biological Process

GO:0010467  gene expression
GO:0000398  nuclear mRNA splicing, via spliceosome
GO:0006396  RNA processing
GO:0008380  RNA splicing
GO:0000375  RNA splicing, via transesterification reactions

Cellular Component

GO:0015030  Cajal body
GO:0016607  nuclear speck
GO:0005730  nucleolus
GO:0005654  nucleoplasm
GO:0005634  nucleus
GO:0005681  spliceosomal complex
GO:0071001  U4/U6 snRNP

Molecular Function

GO:0005515  protein binding