hepatocyte growth factor-regulated tyrosine kinase substrate

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Synonym

Hrs, Protein pp110, ZFYVE8, HGS

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

nodata

GeneChip

cerebrum:7.70

cerebellum:7.48

brain stem:7.65

corpus callosum/glia:7.92

pineal gland:-

peripheral nerve:7.83

spine:7.71

retina:-

eye:-

artery/aorta:7.82

vein:7.23

lymphnode:7.98

peripheral blood:-

spleen:7.99

thymus:7.78

bone marrow:7.67

adipose:7.56

bone:-

skin:7.58

CAGE

cerebrum:3.76

cerebellum:-

brain stem:3.69

corpus callosum/glia:3.66

pineal gland:3.50

peripheral nerve:-

spine:3.59

retina:-

eye:-

artery/aorta:3.80

vein:3.34

lymphnode:3.35

peripheral blood:-

spleen:3.02

thymus:2.99

bone marrow:-

adipose:3.30

bone:-

skin:-

RNA-seq

cerebrum:3.62

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:4.10

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:3.91

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

nodata

GeneChip

uterus:7.51

placenta:7.64

prostate:7.57

ovary:7.27

testis:8.53

heart:7.13

muscle:6.68

esophagus:8.26

stomach:7.72

intestine:7.44

colon:7.57

liver/hepato:7.35

lung:7.87

bladder:-

kidney:7.60

pituitary:7.88

thyroid/parathyroid:7.83

adrenal gland:8.02

pancreas:7.39

breast:7.89

salivary:7.45

CAGE

uterus:3.29

placenta:3.48

prostate:3.19

ovary:3.25

testis:3.81

heart:3.31

muscle:3.59

esophagus:3.33

stomach:-

intestine:3.33

colon:3.51

liver/hepato:2.90

lung:3.30

bladder:3.26

kidney:3.16

pituitary:3.36

thyroid/parathyroid:3.13

adrenal gland:-

pancreas:3.63

breast:3.52

salivary:3.60

RNA-seq

uterus:-

placenta:-

prostate:4.08

ovary:3.99

testis:4.48

heart:2.57

muscle:4.60

esophagus:-

stomach:-

intestine:-

colon:3.31

liver/hepato:2.42

lung:3.29

bladder:-

kidney:3.57

pituitary:-

thyroid/parathyroid:4.11

adrenal gland:3.89

pancreas:-

breast:3.47

salivary:-

IDs

Refseq ID	NM_004712
Gene ID	9146
Unigene ID	-
Probe set ID	210428_s_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000185359
GTEx ID	ENSG00000185359

Orthologous Gene

Mouse[2]	NM_001159328, NM_008244
Rat[2]	NM_001159328, NM_008244

Chromosomal Region

17q25.3 [79,651,020 - 79,669,145]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR008942	ENTH/VHS
IPR002014	VHS
IPR018205	VHS subgroup
IPR000306	Zinc finger, FYVE-type
IPR011011	Zinc finger, FYVE/PHD-type
IPR013083	Zinc finger, RING/FYVE/PHD-type

Gene Ontology (GO ID)

Biological Process

GO:0008333	endosome to lysosome transport
GO:0016197	endosome transport
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0006886	intracellular protein transport
GO:0016044	membrane organization
GO:0008285	negative regulation of cell proliferation
GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway
GO:0046426	negative regulation of JAK-STAT cascade
GO:0042176	regulation of protein catabolic process
GO:0007165	signal transduction

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005769	early endosome
GO:0031901	early endosome membrane
GO:0005768	endosome
GO:0043231	intracellular membrane-bounded organelle
GO:0032585	multivesicular body membrane
GO:0030141	secretory granule

Molecular Function

GO:0046872	metal ion binding
GO:0005515	protein binding
GO:0019904	protein domain specific binding

hepatocyte growth factor-regulated tyrosine kinase substrate

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function