mitogen-activated protein kinase kinase kinase 13

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Synonym

MGC133196, Mixed lineage kinase, Leucine zipper-bearing kinase, mitogen-activated protein kinase kinase kinase 13, MAP3K13, Mitogen-activated protein kinase kinase kinase 13, MLK, LZK

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST nodata
GeneChip cerebrum:5.59 cerebellum:5.75 brain stem:5.41 corpus callosum/glia:5.03 pineal gland:- peripheral nerve:5.08 spine:5.11 retina:- eye:- artery/aorta:5.13 vein:4.74 lymphnode:4.84 peripheral blood:- spleen:4.54 thymus:4.51 bone marrow:4.48 adipose:4.72 bone:- skin:5.07
CAGE cerebrum:3.40 cerebellum:- brain stem:3.30 corpus callosum/glia:3.27 pineal gland:4.18 peripheral nerve:- spine:3.49 retina:- eye:- artery/aorta:2.79 vein:1.95 lymphnode:2.34 peripheral blood:- spleen:2.19 thymus:1.75 bone marrow:- adipose:2.33 bone:- skin:-
RNA-seq cerebrum:0.87 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.00 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.08 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST nodata
GeneChip uterus:4.84 placenta:5.25 prostate:5.30 ovary:5.17 testis:5.04 heart:4.72 muscle:4.85 esophagus:4.95 stomach:5.37 intestine:5.50 colon:5.30 liver/hepato:6.08 lung:4.92 bladder:- kidney:5.65 pituitary:5.64 thyroid/parathyroid:5.34 adrenal gland:5.76 pancreas:5.77 breast:5.07 salivary:5.58
CAGE uterus:2.61 placenta:2.13 prostate:2.78 ovary:2.75 testis:2.79 heart:1.97 muscle:1.60 esophagus:2.73 stomach:- intestine:3.44 colon:2.81     liver/hepato:3.12    lung:3.12 bladder:2.70 kidney:3.15 pituitary:3.55 thyroid/parathyroid:3.11 adrenal gland:- pancreas:3.42 breast:2.27 salivary:3.71
RNA-seq uterus:- placenta:- prostate:0.00 ovary:0.00 testis:0.00 heart:0.00 muscle:0.00 esophagus:- stomach:- intestine:- colon:0.00     liver/hepato:0.00        lung:0.00    bladder:- kidney:0.00 pituitary:- thyroid/parathyroid:0.21 adrenal gland:0.30 pancreas:- breast:0.45 salivary:-

Gene Information

IDs

Refseq ID NM_004721
Gene ID 9175
Unigene ID -
Probe set ID 206249_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000073803
GTEx ID ENSG00000073803

Orthologous Gene

Mouse[2]  NM_172821
Rat[1]  NM_001013978

Chromosomal Region

3q27.2  [185,000,729  -  185,206,885]

Gene Family (Interpro ID)

IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

8274451
9353328
11163770
11726277
12186766
12477932
12492477
14702039
15489334
20379614
21988832
22505724
22623531
22837378

Gene Ontology  (GO ID)

Biological Process

GO:0000186  activation of MAPKK activity
GO:0007254  JNK cascade
GO:0051092  positive regulation of NF-kappaB transcription factor activity
GO:0046777  protein amino acid autophosphorylation
GO:0006468  protein amino acid phosphorylation

Cellular Component

GO:0008385  IkappaB kinase complex
GO:0016020  membrane

Molecular Function

GO:0005524  ATP binding
GO:0042802  identical protein binding
GO:0004709  MAP kinase kinase kinase activity
GO:0046872  metal ion binding
GO:0005515  protein binding
GO:0042803  protein homodimerization activity
GO:0019901  protein kinase binding
GO:0004674  protein serine/threonine kinase activity