Rho/Rac guanine nucleotide exchange factor (GEF) 2

Synonym

GEF-H1, Proliferating cell nucleolar antigen p40, ARHGEF2, GEF, LFP40, DKFZp547P1516, Rho/Rac guanine nucleotide exchange factor 2, GEFH1, rho/rac guanine nucleotide exchange factor (GEF) 2, GEF-H1 protein, KIAA0651, DKFZp547L106

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

nodata

GeneChip

cerebrum:8.54

cerebellum:8.09

brain stem:8.39

corpus callosum/glia:8.86

pineal gland:-

peripheral nerve:8.01

spine:8.54

retina:-

eye:-

artery/aorta:8.47

vein:8.35

lymphnode:8.48

peripheral blood:-

spleen:8.82

thymus:7.93

bone marrow:8.58

adipose:8.29

bone:-

skin:7.22

CAGE

cerebrum:4.42

cerebellum:-

brain stem:4.60

corpus callosum/glia:5.21

pineal gland:2.36

peripheral nerve:-

spine:4.33

retina:-

eye:-

artery/aorta:4.58

vein:4.37

lymphnode:4.19

peripheral blood:-

spleen:4.42

thymus:4.43

bone marrow:-

adipose:4.07

bone:-

skin:-

RNA-seq

cerebrum:0.00

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:0.00

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:2.23

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

nodata

GeneChip

uterus:7.78

placenta:7.75

prostate:6.86

ovary:7.70

testis:7.54

heart:8.09

muscle:7.42

esophagus:7.66

stomach:8.21

intestine:7.44

colon:7.91

liver/hepato:7.37

lung:8.57

bladder:-

kidney:7.71

pituitary:7.26

thyroid/parathyroid:7.92

adrenal gland:7.47

pancreas:7.48

breast:8.05

salivary:7.60

CAGE

uterus:4.07

placenta:3.66

prostate:3.63

ovary:3.85

testis:2.88

heart:3.91

muscle:2.81

esophagus:3.68

stomach:-

intestine:2.92

colon:3.52

liver/hepato:2.53

lung:4.13

bladder:3.68

kidney:2.86

pituitary:2.24

thyroid/parathyroid:3.19

adrenal gland:-

pancreas:2.18

breast:4.22

salivary:3.45

RNA-seq

uterus:-

placenta:-

prostate:0.00

ovary:0.07

testis:0.00

heart:0.00

muscle:0.00

esophagus:-

stomach:-

intestine:-

colon:0.00

liver/hepato:0.40

lung:0.01

bladder:-

kidney:0.93

pituitary:-

thyroid/parathyroid:0.59

adrenal gland:0.00

pancreas:-

breast:0.01

salivary:-

IDs

Refseq ID	NM_001162384
Gene ID	9181
Unigene ID	-
Probe set ID	209435_s_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000116584
GTEx ID	ENSG00000116584

Orthologous Gene

Mouse[3]	NM_001198911, NM_001198912, NM_001198913, NM_008487
Rat[1]	NM_001012079, NM_001198912, NM_001198913, NM_008487

Chromosomal Region

1q22 [155,916,645 - 155,966,129]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR001849

Pleckstrin homology

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

GO:0007015	actin filament organization
GO:0051301	cell division
GO:0000902	cell morphogenesis
GO:0071474	cellular hyperosmotic response
GO:0071356	cellular response to tumor necrosis factor
GO:0000132	establishment of mitotic spindle orientation
GO:0006886	intracellular protein transport
GO:0007067	mitosis
GO:0007026	negative regulation of microtubule depolymerization
GO:0060547	negative regulation of necrotic cell death
GO:0050768	negative regulation of neurogenesis
GO:0048011	nerve growth factor receptor signaling pathway
GO:0043065	positive regulation of apoptosis
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0042127	regulation of cell proliferation
GO:0035023	regulation of Rho protein signal transduction
GO:0051056	regulation of small GTPase mediated signal transduction
GO:0007264	small GTPase mediated signal transduction

Cellular Component

GO:0043025	cell soma
GO:0005829	cytosol
GO:0043198	dendritic shaft
GO:0005794	Golgi apparatus
GO:0005874	microtubule
GO:0032587	ruffle membrane
GO:0005819	spindle
GO:0005923	tight junction

Molecular Function

GO:0008017	microtubule binding
GO:0005543	phospholipid binding
GO:0005515	protein binding
GO:0048365	Rac GTPase binding
GO:0030676	Rac guanyl-nucleotide exchange factor activity
GO:0017048	Rho GTPase binding
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0008134	transcription factor binding
GO:0008270	zinc ion binding

Rho/Rac guanine nucleotide exchange factor (GEF) 2

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function