activin A receptor, type IIA

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Synonym

activin A receptor, type IIA, ACTR-IIA, Activin receptor type 2A precursor, Activin receptor type IIA, ACVR2A, ACTRIIA, ACVR2, ACTRII

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:40.30 cerebellum:50.40 brain stem:6535.90 corpus callosum/glia:- pineal gland:148.30 peripheral nerve:- spine:112.30 retina:118.60 eye:5.90 artery/aorta:30 vein:133.30 lymphnode:- peripheral blood:36.40 spleen:- thymus:25.80 bone marrow:- adipose:40.30 bone:- skin:38.40
GeneChip cerebrum:6.54 cerebellum:6.44 brain stem:6.53 corpus callosum/glia:6.52 pineal gland:- peripheral nerve:7.02 spine:6.44 retina:- eye:- artery/aorta:6.62 vein:7.04 lymphnode:6.48 peripheral blood:- spleen:6.44 thymus:6.11 bone marrow:6.48 adipose:7.21 bone:- skin:7.74
CAGE cerebrum:2.71 cerebellum:- brain stem:2.41 corpus callosum/glia:2.29 pineal gland:3.44 peripheral nerve:- spine:2.36 retina:- eye:- artery/aorta:2.36 vein:2.29 lymphnode:2.39 peripheral blood:- spleen:2.51 thymus:1.47 bone marrow:- adipose:2.80 bone:- skin:-
RNA-seq cerebrum:2.15 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:1.81 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:2.12 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:36.50 placenta:36.40 prostate:- ovary:111.80 testis:17.30 heart:51.10 muscle:- esophagus:342.80 stomach:- intestine:32.40 colon:93.30     liver/hepato:10.60        lung:24.40    bladder:- kidney:93.60 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:35.60 breast:250.90 salivary:-
GeneChip uterus:6.79 placenta:6.97 prostate:7.04 ovary:6.58 testis:7.10 heart:6.74 muscle:6.79 esophagus:6.98 stomach:6.79 intestine:6.86 colon:6.81 liver/hepato:6.74 lung:6.64 bladder:- kidney:6.61 pituitary:6.42 thyroid/parathyroid:6.54 adrenal gland:6.43 pancreas:6.90 breast:7.44 salivary:6.49
CAGE uterus:2.92 placenta:2.60 prostate:3.11 ovary:2.47 testis:2.92 heart:2.28 muscle:2.38 esophagus:3.15 stomach:- intestine:3.36 colon:2.87     liver/hepato:2.30    lung:2.52 bladder:3.11 kidney:2.78 pituitary:3.07 thyroid/parathyroid:2.46 adrenal gland:- pancreas:2.76 breast:1.92 salivary:2.93
RNA-seq uterus:- placenta:- prostate:3.06 ovary:2.46 testis:2.77 heart:1.34 muscle:1.94 esophagus:- stomach:- intestine:- colon:2.27     liver/hepato:1.58        lung:1.72    bladder:- kidney:2.12 pituitary:- thyroid/parathyroid:2.28 adrenal gland:2.16 pancreas:- breast:2.53 salivary:-

Gene Information

IDs

Refseq ID NM_001616
Gene ID 92
Unigene ID Hs.470174
Probe set ID 205327_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000121989
GTEx ID ENSG00000121989

Orthologous Gene

Mouse[2]  NM_007396
Rat [0]  

Chromosomal Region

2q22.3  [148,602,086  -  148,688,393]

Gene Family (Interpro ID)

IPR000333  Activin type II receptor
IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

1311955
1314589
1646080
7890768
8242742
8243335
8358434
8612709
8622651
8640777
8702914
8889548
8889549
8971337
9032295
9202237
9748228
9872992
9892009
10187774
10323406
10504300
10638976
10681527
10702675
10746731
11069203
11266516
11882656
11969340
12032389
12135884
12213882
12385827
12477932
12651901
12665502
12667445
14691305
14738881
14988818
15123239
15451561
15489334
15611116
15621726
15815621
16337854
16344560
16380996
16461635
16672363
16982625
17258738
17356069
17456004
17472960
18001154
18436533
18781190
18941508
19064572
19126782
19308291
19366699
19386982
19503063
19574343
20011542
20197483
20200332
20339536
20379614
20424473
20634197
20734064
20801928
20886391
21139048
21353880
21378277
21490791
21906983
21976273
22001236
22085900
22296042
22528352
22718755
22723898
22848350
22949641
23263486
23633461

Gene Ontology  (GO ID)

Biological Process

GO:0009952  anterior/posterior pattern formation
GO:0030509  BMP signaling pathway
GO:0007368  determination of left/right symmetry
GO:0048706  embryonic skeletal system development
GO:0001702  gastrulation with mouth forming second
GO:0007498  mesoderm development
GO:0043084  penile erection
GO:0032927  positive regulation of activin receptor signaling pathway
GO:0030501  positive regulation of bone mineralization
GO:0045648  positive regulation of erythrocyte differentiation
GO:0045669  positive regulation of osteoblast differentiation
GO:0010862  positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0001934  positive regulation of protein amino acid phosphorylation
GO:0030510  regulation of BMP signaling pathway
GO:0050999  regulation of nitric-oxide synthase activity
GO:0060011  Sertoli cell proliferation
GO:0042713  sperm ejaculation
GO:0007283  spermatogenesis
GO:0007178  transmembrane receptor protein serine/threonine kinase signaling pathway

Cellular Component

GO:0009986  cell surface
GO:0005737  cytoplasm
GO:0034673  inhibin-betaglycan-ActRII complex
GO:0005887  integral to plasma membrane
GO:0005886  plasma membrane

Molecular Function

GO:0048185  activin binding
GO:0017002  activin receptor activity
GO:0005524  ATP binding
GO:0015026  coreceptor activity
GO:0019838  growth factor binding
GO:0034711  inhibin binding
GO:0046872  metal ion binding
GO:0030165  PDZ domain binding
GO:0005515  protein binding
GO:0043621  protein self-association
GO:0004674  protein serine/threonine kinase activity
GO:0004702  receptor signaling protein serine/threonine kinase activity
GO:0005024  transforming growth factor beta receptor activity
GO:0004675  transmembrane receptor protein serine/threonine kinase activity