mitogen-activated protein kinase-activated protein kinase 2

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Synonym

MAPK-activated protein kinase 2, MK2, MAPKAPK2, MAPKAP kinase 2, MAP kinase-activated protein kinase 2, MAPKAPK-2

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST nodata
GeneChip cerebrum:5.78 cerebellum:6.06 brain stem:5.79 corpus callosum/glia:5.91 pineal gland:- peripheral nerve:5.98 spine:5.96 retina:- eye:- artery/aorta:6.21 vein:6.12 lymphnode:5.96 peripheral blood:- spleen:5.97 thymus:6.08 bone marrow:6.45 adipose:6.23 bone:- skin:6
CAGE cerebrum:3.38 cerebellum:- brain stem:3.75 corpus callosum/glia:3.95 pineal gland:4.88 peripheral nerve:- spine:3.76 retina:- eye:- artery/aorta:4.21 vein:4.05 lymphnode:4.28 peripheral blood:- spleen:4.69 thymus:4.20 bone marrow:- adipose:4.27 bone:- skin:-
RNA-seq cerebrum:0.31 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.98 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:1.07 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST nodata
GeneChip uterus:5.93 placenta:5.96 prostate:5.92 ovary:5.72 testis:6.54 heart:6.54 muscle:6.40 esophagus:6.14 stomach:6.12 intestine:6.19 colon:6.15 liver/hepato:5.90 lung:6 bladder:- kidney:6.03 pituitary:6.10 thyroid/parathyroid:5.94 adrenal gland:6.04 pancreas:6.70 breast:5.86 salivary:6.24
CAGE uterus:4.01 placenta:3.61 prostate:4.12 ovary:4.24 testis:4.24 heart:5.08 muscle:4.71 esophagus:4.24 stomach:- intestine:4.54 colon:4.04     liver/hepato:4.21    lung:4.37 bladder:4.21 kidney:4.55 pituitary:4.11 thyroid/parathyroid:4.21 adrenal gland:- pancreas:3.90 breast:4.34 salivary:4.01
RNA-seq uterus:- placenta:- prostate:0.97 ovary:0.53 testis:0.43 heart:1.59 muscle:2.63 esophagus:- stomach:- intestine:- colon:0.67     liver/hepato:1.66        lung:1.77    bladder:- kidney:1.87 pituitary:- thyroid/parathyroid:1.92 adrenal gland:1.99 pancreas:- breast:0.91 salivary:-

Gene Information

IDs

Refseq ID NM_004759
Gene ID 9261
Unigene ID -
Probe set ID 215050_x_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000162889
GTEx ID ENSG00000162889

Orthologous Gene

Mouse[1]  NM_008551
Rat [0]  

Chromosomal Region

1q32.1  [206,858,289  -  206,907,628]

Gene Family (Interpro ID)

IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

1332886
6150037
7592979
7799959
7901013
7905823
7923354
8179591
8280084
8413226
8617238
8774846
8846784
8887554
8995217
8995385
9297626
9628873
9687510
9759836
9768359
10318869
10383393
10559880
10753652
10779545
10781029
11042204
11359875
11448140
11520933
11551945
11839738
11844797
12147348
12171600
12171911
12377770
12456657
12477932
12565831
12582162
12751751
12791252
12829704
12861023
14499342
14517288
14688255
15014438
15094067
15271996
15276183
15287722
15489334
15629715
15688025
15692053
15850461
16278218
16407830
16424170
16456544
16774924
16861915
17030608
17255097
17292828
17395714
17481585
18160429
18326031
18371353
18440775
19171422
19322201
19672773
19951368
20068172
20081887
20212154
20375303
20595389
20805296
20932473
21078877
21131586
21145461
21182205
21606198
21675959
21988832
22119462
22200507
22268119
22351694
22883146
22983351
23128233
23152511
23185379
23202365
23264053
23455922
23602568
23657501
23740979
23744329
24020373
24056810
24082115
24469230
24816145

Gene Ontology  (GO ID)

Biological Process

GO:0070935  3'-UTR-mediated mRNA stabilization
GO:0000187  activation of MAPK activity
GO:0019369  arachidonic acid metabolic process
GO:0031572  G2/M transition DNA damage checkpoint
GO:0010467  gene expression
GO:0006954  inflammatory response
GO:0045087  innate immune response
GO:0048839  inner ear development
GO:0006691  leukotriene metabolic process
GO:0000165  MAPKKK cascade
GO:0016071  mRNA metabolic process
GO:0002755  MyD88-dependent toll-like receptor signaling pathway
GO:0002756  MyD88-independent toll-like receptor signaling pathway
GO:0048011  nerve growth factor receptor signaling pathway
GO:0018105  peptidyl-serine phosphorylation
GO:0006468  protein amino acid phosphorylation
GO:0007265  Ras protein signal transduction
GO:0032675  regulation of interleukin-6 production
GO:0032680  regulation of tumor necrosis factor production
GO:0006974  response to DNA damage stimulus
GO:0032496  response to lipopolysaccharide
GO:0006950  response to stress
GO:0016070  RNA metabolic process
GO:0051403  stress-activated MAPK cascade
GO:0034166  toll-like receptor 10 signaling pathway
GO:0034134  toll-like receptor 2 signaling pathway
GO:0034138  toll-like receptor 3 signaling pathway
GO:0034142  toll-like receptor 4 signaling pathway
GO:0034146  toll-like receptor 5 signaling pathway
GO:0034162  toll-like receptor 9 signaling pathway
GO:0002224  toll-like receptor signaling pathway
GO:0048010  vascular endothelial growth factor receptor signaling pathway

Cellular Component

GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0005654  nucleoplasm
GO:0005634  nucleus

Molecular Function

GO:0005524  ATP binding
GO:0005515  protein binding
GO:0004672  protein kinase activity
GO:0004674  protein serine/threonine kinase activity
GO:0004871  signal transducer activity