serine/threonine kinase 17b

 jump to detail

Synonym

Serine/threonine-protein kinase 17B, STK17B, serine/threonine kinase 17b (apoptosis-inducing), DRAK2

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:9.50 cerebellum:37.80 brain stem:- corpus callosum/glia:29.20 pineal gland:- peripheral nerve:- spine:- retina:- eye:11.80 artery/aorta:89.90 vein:- lymphnode:171.90 peripheral blood:18.20 spleen:56.70 thymus:116 bone marrow:98.40 adipose:- bone:12.80 skin:28.80
GeneChip cerebrum:3.28 cerebellum:3.42 brain stem:3.31 corpus callosum/glia:3.17 pineal gland:- peripheral nerve:3.50 spine:3.45 retina:- eye:- artery/aorta:3.62 vein:3.79 lymphnode:5.93 peripheral blood:- spleen:6.23 thymus:5.99 bone marrow:6.33 adipose:4.32 bone:- skin:4.09
CAGE cerebrum:2.77 cerebellum:- brain stem:2.47 corpus callosum/glia:2.47 pineal gland:2.37 peripheral nerve:- spine:3.02 retina:- eye:- artery/aorta:4.09 vein:5.58 lymphnode:5.76 peripheral blood:- spleen:5.83 thymus:5.86 bone marrow:- adipose:4.87 bone:- skin:-
RNA-seq cerebrum:1.20 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:5.48 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:4.43 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:27.30 placenta:21.90 prostate:11.30 ovary:- testis:82.20 heart:- muscle:20.10 esophagus:- stomach:- intestine:32.40 colon:8.50     liver/hepato:-        lung:44    bladder:- kidney:10.40 pituitary:116 thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:3.48 placenta:3.76 prostate:4.18 ovary:3.33 testis:4.93 heart:3.66 muscle:3.36 esophagus:3.53 stomach:4.10 intestine:3.63 colon:4.06 liver/hepato:3.55 lung:4.90 bladder:- kidney:3.33 pituitary:3.23 thyroid/parathyroid:3.61 adrenal gland:3.49 pancreas:3.67 breast:3.67 salivary:4.27
CAGE uterus:3.58 placenta:3.66 prostate:3.83 ovary:3.09 testis:3.36 heart:3.43 muscle:3.04 esophagus:4.04 stomach:- intestine:5.20 colon:4.25     liver/hepato:2.77    lung:4.98 bladder:4.25 kidney:3.81 pituitary:3.28 thyroid/parathyroid:3.55 adrenal gland:- pancreas:3.16 breast:4.04 salivary:4.19
RNA-seq uterus:- placenta:- prostate:2.43 ovary:1.84 testis:2.49 heart:2.28 muscle:1.02 esophagus:- stomach:- intestine:- colon:2.52     liver/hepato:1.17        lung:4.16    bladder:- kidney:2.77 pituitary:- thyroid/parathyroid:3.48 adrenal gland:5.24 pancreas:- breast:3.73 salivary:-

Gene Information

IDs

Refseq ID NM_004226
Gene ID 9262
Unigene ID Hs.88297
Probe set ID 205214_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000081320
GTEx ID ENSG00000081320

Orthologous Gene

Mouse[2]  NM_133810
Rat[1]  NM_133392

Chromosomal Region

2q32.3  [196,998,290  -  197,041,227]

Gene Family (Interpro ID)

IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

9786912
11481038
12477932
15489334
17182616
19542440
19638987
19730683
20379614
21148796
21832049
21963094
21988832
22505724
23122956
23398943

Gene Ontology  (GO ID)

Biological Process

GO:0006915  apoptosis
GO:0046777  protein amino acid autophosphorylation
GO:0006468  protein amino acid phosphorylation
GO:0007243  protein kinase cascade

Cellular Component

GO:0015629  actin cytoskeleton
GO:0005793  ER-Golgi intermediate compartment
GO:0005634  nucleus
GO:0005886  plasma membrane

Molecular Function

GO:0005524  ATP binding
GO:0004672  protein kinase activity
GO:0004674  protein serine/threonine kinase activity