activin A receptor, type IIB

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Synonym

MGC116908, activin A receptor, type IIB, Activin receptor type IIB, Activin receptor type 2B precursor, ACVR2B, ACTR-IIB, ActR-IIB

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:2.40 cerebellum:25.20 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:61.30 spine:- retina:- eye:5.90 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:25.80 bone marrow:- adipose:- bone:- skin:-
GeneChip nodata
CAGE cerebrum:1.91 cerebellum:- brain stem:1.88 corpus callosum/glia:2.21 pineal gland:1.67 peripheral nerve:- spine:1.72 retina:- eye:- artery/aorta:1.38 vein:1.69 lymphnode:0.88 peripheral blood:- spleen:1.43 thymus:2.58 bone marrow:- adipose:1.60 bone:- skin:-
RNA-seq nodata
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:40.10 prostate:- ovary:- testis:- heart:- muscle:- esophagus:- stomach:21.20 intestine:- colon:8.50     liver/hepato:-        lung:4.90    bladder:- kidney:- pituitary:116 thyroid/parathyroid:- adrenal gland:- pancreas:17.80 breast:9.30 salivary:-
GeneChip nodata
CAGE uterus:1.89 placenta:2.86 prostate:1.66 ovary:1.29 testis:2.39 heart:1.61 muscle:1.75 esophagus:1.48 stomach:- intestine:1.05 colon:1.90     liver/hepato:0.36    lung:1.96 bladder:1.52 kidney:1.01 pituitary:1.88 thyroid/parathyroid:1.85 adrenal gland:- pancreas:1.42 breast:1.92 salivary:1.00
RNA-seq nodata

Gene Information

IDs

Refseq ID NM_001106000
Gene ID 93
Unigene ID Hs.174273
Probe set ID -
Ensembl ID -
GTEx ID -

Orthologous Gene

Mouse [0]  
Rat [0]  

Chromosomal Region

3p22.2  [38,495,342  -  38,524,948]

Gene Family (Interpro ID)

IPR000333  Activin type II receptor
IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

8161782
8242742
8612709
8622651
8702914
9202237
9621519
9748228
9872992
9916847
10212081
10391213
10504300
10702675
10766733
11094085
11266516
11278302
11279102
11306176
11459935
11882656
11969340
12477932
12493773
12651901
12782414
14517293
14738881
15064755
15123239
15123686
15304227
15342556
15451561
15489334
15611116
15621726
16845371
17347381
17356069
17893364
18436533
19453261
19903896
20424473
20466801
20663871
20734064
21353874
21864452
22296042
22395277
22431721
22718755
22939624

Gene Ontology  (GO ID)

Biological Process

GO:0032147  activation of protein kinase activity
GO:0009952  anterior/posterior pattern formation
GO:0060840  artery development
GO:0001974  blood vessel remodeling
GO:0030509  BMP signaling pathway
GO:0007368  determination of left/right symmetry
GO:0048617  embryonic foregut morphogenesis
GO:0001702  gastrulation with mouth forming second
GO:0007507  heart development
GO:0030073  insulin secretion
GO:0001822  kidney development
GO:0030324  lung development
GO:0001946  lymphangiogenesis
GO:0060836  lymphatic endothelial cell differentiation
GO:0007498  mesoderm development
GO:0042475  odontogenesis of dentine-containing tooth
GO:0035265  organ growth
GO:0060021  palate development
GO:0031016  pancreas development
GO:0032927  positive regulation of activin receptor signaling pathway
GO:0030501  positive regulation of bone mineralization
GO:0045669  positive regulation of osteoblast differentiation
GO:0009791  post-embryonic development
GO:0006355  regulation of transcription, DNA-dependent
GO:0009749  response to glucose stimulus
GO:0007165  signal transduction
GO:0048705  skeletal system morphogenesis
GO:0007178  transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0060841  venous blood vessel development

Cellular Component

GO:0009986  cell surface
GO:0005737  cytoplasm
GO:0005887  integral to plasma membrane
GO:0005886  plasma membrane

Molecular Function

GO:0048185  activin binding
GO:0016362  activin receptor activity, type II
GO:0005524  ATP binding
GO:0019838  growth factor binding
GO:0034711  inhibin binding
GO:0046872  metal ion binding
GO:0005515  protein binding
GO:0004674  protein serine/threonine kinase activity
GO:0004712  protein serine/threonine/tyrosine kinase activity
GO:0004702  receptor signaling protein serine/threonine kinase activity
GO:0005024  transforming growth factor beta receptor activity