CCR4-NOT transcription complex, subunit 8

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Synonym

CCR4-NOT transcription complex subunit 8, CNOT8, hCAF1, CCR4-NOT transcription complex, subunit 8, CALIFp, CCR4-associated factor 8, CAF1-like protein, CAF2, CALIF

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:- cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:23.50 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:18.90 thymus:12.90 bone marrow:- adipose:- bone:- skin:14.40
GeneChip cerebrum:6.02 cerebellum:6.23 brain stem:6 corpus callosum/glia:6.39 pineal gland:- peripheral nerve:6.18 spine:6.46 retina:- eye:- artery/aorta:5.85 vein:5.93 lymphnode:6.24 peripheral blood:- spleen:7.03 thymus:7.95 bone marrow:6.79 adipose:6.62 bone:- skin:6.52
CAGE cerebrum:3.42 cerebellum:- brain stem:3.57 corpus callosum/glia:3.45 pineal gland:3.41 peripheral nerve:- spine:3.67 retina:- eye:- artery/aorta:3.71 vein:3.57 lymphnode:3.63 peripheral blood:- spleen:3.47 thymus:3.90 bone marrow:- adipose:3.83 bone:- skin:-
RNA-seq cerebrum:4.56 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:5.01 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:4.82 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:7.30 prostate:- ovary:- testis:- heart:- muscle:- esophagus:- stomach:849.70 intestine:- colon:118.70     liver/hepato:-        lung:73.30    bladder:125.60 kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:6.78 placenta:6.57 prostate:6.81 ovary:6.82 testis:6.37 heart:6.03 muscle:5.54 esophagus:6.04 stomach:6.32 intestine:6.46 colon:6.69 liver/hepato:5.37 lung:6.75 bladder:- kidney:5.92 pituitary:5.49 thyroid/parathyroid:6.20 adrenal gland:5.82 pancreas:6.10 breast:6.63 salivary:6.14
CAGE uterus:3.17 placenta:3.12 prostate:3.24 ovary:3.13 testis:3.48 heart:3.31 muscle:3.00 esophagus:3.25 stomach:- intestine:3.43 colon:3.49     liver/hepato:2.79    lung:3.94 bladder:3.56 kidney:3.00 pituitary:3.19 thyroid/parathyroid:3.86 adrenal gland:- pancreas:3.02 breast:3.71 salivary:3.15
RNA-seq uterus:- placenta:- prostate:4.74 ovary:4.36 testis:5.11 heart:3.66 muscle:3.21 esophagus:- stomach:- intestine:- colon:4.93     liver/hepato:3.31        lung:5.39    bladder:- kidney:4.40 pituitary:- thyroid/parathyroid:4.62 adrenal gland:4.92 pancreas:- breast:4.69 salivary:-

Gene Information

IDs

Refseq ID NM_004779
Gene ID 9337
Unigene ID Hs.267038
Probe set ID 202164_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000155508
GTEx ID ENSG00000155508

Orthologous Gene

Mouse[2]  NM_026949
Rat[1]  NM_001008382

Chromosomal Region

5q33.2  [154,237,113  -  154,256,353]

Gene Family (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

9820826
10036195
10637334
11076863
11136725
11230166
11256614
12477932
12771185
14702039
15489334
15489336
15769875
16381901
16778766
17178784
17264152
17353931
19322201
19558367
19605561
20065043
20360068
20595389
20595394
21139048
21336257
21890473
21900206
21906983
21963094
21987572
22505724
22683897
22977175
23236473
23383273
24036545
24115769

Gene Ontology  (GO ID)

Biological Process

GO:0043928  exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
GO:0010467  gene expression
GO:0035195  gene silencing by miRNA
GO:0016071  mRNA metabolic process
GO:0008285  negative regulation of cell proliferation
GO:0000288  nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0000289  nuclear-transcribed mRNA poly(A) tail shortening
GO:0008284  positive regulation of cell proliferation
GO:0006355  regulation of transcription, DNA-dependent
GO:0006417  regulation of translation
GO:0016070  RNA metabolic process
GO:0006351  transcription, DNA-dependent

Cellular Component

GO:0030014  CCR4-NOT complex
GO:0005829  cytosol
GO:0005622  intracellular
GO:0005634  nucleus

Molecular Function

GO:0000175  3'-5'-exoribonuclease activity
GO:0046872  metal ion binding
GO:0004535  poly(A)-specific ribonuclease activity
GO:0005515  protein binding
GO:0003723  RNA binding
GO:0003700  transcription factor activity