slit homolog 2 (Drosophila)

 jump to detail

Synonym

Slit-2, SLIT2, Slit homolog 2 protein precursor, slit (Drosophila) homolog 2, FLJ14420, SLIL3, slit homolog 2 (Drosophila)

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST nodata
GeneChip cerebrum:7.33 cerebellum:5.57 brain stem:6.49 corpus callosum/glia:6.46 pineal gland:- peripheral nerve:8.84 spine:6.66 retina:- eye:- artery/aorta:8.25 vein:8.47 lymphnode:6.68 peripheral blood:- spleen:8.50 thymus:5.91 bone marrow:5.70 adipose:7.49 bone:- skin:7
CAGE cerebrum:0.98 cerebellum:- brain stem:0.50 corpus callosum/glia:0.39 pineal gland:0.36 peripheral nerve:- spine:0.40 retina:- eye:- artery/aorta:1.16 vein:0.59 lymphnode:0.39 peripheral blood:- spleen:2.60 thymus:0.12 bone marrow:- adipose:0.90 bone:- skin:-
RNA-seq cerebrum:1.75 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.42 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:1.60 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST nodata
GeneChip uterus:8.46 placenta:6.51 prostate:8.03 ovary:7.69 testis:5.80 heart:7.43 muscle:6.21 esophagus:7.28 stomach:7.75 intestine:6.89 colon:7.29 liver/hepato:5.54 lung:9.86 bladder:- kidney:7.71 pituitary:7.44 thyroid/parathyroid:8.01 adrenal gland:9.39 pancreas:5.91 breast:8.07 salivary:6.77
CAGE uterus:2.11 placenta:1.05 prostate:1.66 ovary:1.29 testis:0.62 heart:0.72 muscle:0.24 esophagus:1.36 stomach:- intestine:0.69 colon:1.17     liver/hepato:0.14    lung:2.57 bladder:1.49 kidney:1.50 pituitary:1.08 thyroid/parathyroid:0.64 adrenal gland:- pancreas:0 breast:0.90 salivary:0.62
RNA-seq uterus:- placenta:- prostate:3.37 ovary:1.83 testis:2.03 heart:1.50 muscle:0.58 esophagus:- stomach:- intestine:- colon:2.95     liver/hepato:0.26        lung:4.32    bladder:- kidney:1.92 pituitary:- thyroid/parathyroid:2.39 adrenal gland:1.73 pancreas:- breast:2.20 salivary:-

Gene Information

IDs

Refseq ID NM_004787
Gene ID 9353
Unigene ID -
Probe set ID 209897_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000145147
GTEx ID ENSG00000145147

Orthologous Gene

Mouse[4]  NM_178804
Rat[1]  NM_022632

Chromosomal Region

4p15.31  [20,254,883  -  20,622,184]

Gene Family (Interpro ID)

IPR008985  Concanavalin A-like lectin/glucanase
IPR013320  Concanavalin A-like lectin/glucanase, subgroup
IPR006207  Cystine knot, C-terminal
IPR001881  EGF-like calcium-binding
IPR000742  EGF-like, type 3
IPR003645  Follistatin-like, N-terminal
IPR001791  Laminin G

Link to Pubmed  (Pubmed ID)

9813312
10102266
10102268
10102269
10197527
10349621
10364234
10432110
10575218
10864954
10892742
10975526
11222645
11239147
11309622
11375980
11404413
11748139
12141424
12200164
12384551
12477932
12615722
12881718
12941633
14645233
14702039
15130495
15207848
15489334
16162649
16439689
16636676
16840550
17062560
17268810
17314511
17448996
17496152
17609981
17848514
17903301
17968499
18269211
18345009
18566128
18611862
18829537
18985028
19005219
19033678
19048120
19056867
19100240
19350278
19351956
19498462
19550140
19706539
19759280
19851296
19855388
19913121
20008733
20029409
20068157
20153733
20198315
20375003
20379614
20438712
20628086
20944010
21264840
21283129
21349947
21385904
21465248
21627385
21686327
21857494
21894562
21986575
22011669
22198087
22241990
22315090
22532293
22613430
22719878
22826604
22865890
22875847
22898079
23119100
23294842
23314748
23314850
23333304
23381221
23671423
23694962
23702092
23933755
24272999
24448236

Gene Ontology  (GO ID)

Biological Process

GO:0048846  axon extension involved in axon guidance
GO:0007411  axon guidance
GO:0048754  branching morphogenesis of a tube
GO:0002042  cell migration involved in sprouting angiogenesis
GO:0016337  cell-cell adhesion
GO:0071504  cellular response to heparin
GO:0032870  cellular response to hormone stimulus
GO:0021834  chemorepulsion involved in embryonic olfactory bulb interneuron migration
GO:0021836  chemorepulsion involved in postnatal olfactory bulb interneuron migration
GO:0021972  corticospinal neuron axon guidance through the spinal cord
GO:0033563  dorsal/ventral axon guidance
GO:0001701  in utero embryonic development
GO:0050929  induction of negative chemotaxis
GO:0060763  mammary duct terminal end bud growth
GO:0001656  metanephros development
GO:0008045  motor axon guidance
GO:0050919  negative chemotaxis
GO:0030837  negative regulation of actin filament polymerization
GO:0030308  negative regulation of cell growth
GO:0030336  negative regulation of cell migration
GO:0008285  negative regulation of cell proliferation
GO:0070100  negative regulation of chemokine-mediated signaling pathway
GO:0010596  negative regulation of endothelial cell migration
GO:0010629  negative regulation of gene expression
GO:0010593  negative regulation of lamellipodium assembly
GO:0002689  negative regulation of leukocyte chemotaxis
GO:0090027  negative regulation of monocyte chemotaxis
GO:0090024  negative regulation of neutrophil chemotaxis
GO:0001933  negative regulation of protein amino acid phosphorylation
GO:0051058  negative regulation of small GTPase mediated signal transduction
GO:0014912  negative regulation of smooth muscle cell migration
GO:0043116  negative regulation of vascular permeability
GO:0043065  positive regulation of apoptosis
GO:0050772  positive regulation of axonogenesis
GO:0051414  response to cortisol stimulus
GO:0031290  retinal ganglion cell axon guidance
GO:0001657  ureteric bud development

Cellular Component

GO:0009986  cell surface
GO:0005737  cytoplasm
GO:0005576  extracellular region
GO:0005615  extracellular space
GO:0016020  membrane
GO:0005886  plasma membrane

Molecular Function

GO:0005509  calcium ion binding
GO:0045499  chemorepellent activity
GO:0005095  GTPase inhibitor activity
GO:0008201  heparin binding
GO:0043237  laminin-1 binding
GO:0005515  protein binding
GO:0042803  protein homodimerization activity
GO:0043394  proteoglycan binding
GO:0048495  Roundabout binding