klotho

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Synonym

klotho, KL, Klotho precursor

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:4.70

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:30.70

spine:-

retina:-

eye:5.90

artery/aorta:-

vein:-

lymphnode:-

peripheral blood:-

spleen:18.90

thymus:-

bone marrow:-

adipose:-

bone:12.80

skin:-

GeneChip

cerebrum:3.14

cerebellum:3.03

brain stem:2.85

corpus callosum/glia:2.90

pineal gland:-

peripheral nerve:3.13

spine:2.83

retina:-

eye:-

artery/aorta:3.31

vein:3.02

lymphnode:2.99

peripheral blood:-

spleen:3.73

thymus:2.92

bone marrow:2.91

adipose:3.80

bone:-

skin:3.32

CAGE

cerebrum:0.54

cerebellum:-

brain stem:0.27

corpus callosum/glia:1.86

pineal gland:0.21

peripheral nerve:-

spine:0.52

retina:-

eye:-

artery/aorta:0.79

vein:1.69

lymphnode:0.46

peripheral blood:-

spleen:1.77

thymus:0.12

bone marrow:-

adipose:2.17

bone:-

skin:-

RNA-seq

cerebrum:0.77

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:1.73

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:1.96

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:-

placenta:25.50

prostate:33.80

ovary:-

testis:-

heart:-

muscle:-

esophagus:-

stomach:42.50

intestine:32.40

colon:76.30

liver/hepato:-

lung:-

bladder:-

kidney:311.90

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:-

breast:-

salivary:-

GeneChip

uterus:3.32

placenta:6.18

prostate:6.14

ovary:2.98

testis:2.91

heart:3.33

muscle:3.06

esophagus:2.95

stomach:3.56

intestine:3.40

colon:3.16

liver/hepato:2.80

lung:5.05

bladder:-

kidney:8.85

pituitary:2.91

thyroid/parathyroid:3.19

adrenal gland:2.89

pancreas:2.93

breast:3.60

salivary:3

CAGE

uterus:0.85

placenta:3.66

prostate:1.58

ovary:0.60

testis:0.45

heart:1.15

muscle:0.49

esophagus:0.94

stomach:-

intestine:1.82

colon:1.54

liver/hepato:0.26

lung:2.72

bladder:0.87

kidney:4.61

pituitary:0

thyroid/parathyroid:1.21

adrenal gland:-

pancreas:1.21

breast:2.69

salivary:0.36

RNA-seq

uterus:-

placenta:-

prostate:1.87

ovary:0.50

testis:1.13

heart:0.53

muscle:0.69

esophagus:-

stomach:-

intestine:-

colon:2.15

liver/hepato:0.12

lung:2.64

bladder:-

kidney:4.75

pituitary:-

thyroid/parathyroid:1.34

adrenal gland:1.13

pancreas:-

breast:1.49

salivary:-

IDs

Refseq ID	NM_004795
Gene ID	9365
Unigene ID	Hs.524953
Probe set ID	205978_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000133116
GTEx ID	ENSG00000133116

Orthologous Gene

Mouse[1]	NM_013823
Rat [0]

Chromosomal Region

13q13.1 [33,590,207 - 33,640,282]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR001360

Glycoside hydrolase, family 1

Gene Ontology (GO ID)

Biological Process

GO:0002526	acute inflammatory response
GO:0007568	aging
GO:0055074	calcium ion homeostasis
GO:0005975	carbohydrate metabolic process
GO:0006112	energy reserve metabolic process
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0045087	innate immune response
GO:0008286	insulin receptor signaling pathway
GO:0048011	nerve growth factor receptor signaling pathway
GO:0048015	phosphoinositide-mediated signaling
GO:0030501	positive regulation of bone mineralization
GO:0090080	positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0016021	integral to membrane
GO:0005887	integral to plasma membrane
GO:0005886	plasma membrane

Molecular Function

GO:0008422	beta-glucosidase activity
GO:0004566	beta-glucuronidase activity
GO:0017134	fibroblast growth factor binding
GO:0005104	fibroblast growth factor receptor binding
GO:0005179	hormone activity
GO:0004871	signal transducer activity
GO:0005499	vitamin D binding

klotho

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function