solute carrier family 22 (organic anion transporter), member 8

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Synonym

MGC24086, OAT3, SLC22A8

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:20.10 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:64.60 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip cerebrum:5.17 cerebellum:5.04 brain stem:5.34 corpus callosum/glia:4.81 pineal gland:- peripheral nerve:4.80 spine:4.75 retina:- eye:- artery/aorta:4.89 vein:5.32 lymphnode:4.61 peripheral blood:- spleen:4.40 thymus:4.18 bone marrow:5.04 adipose:4.96 bone:- skin:5.21
CAGE cerebrum:0.81 cerebellum:- brain stem:0.83 corpus callosum/glia:2.98 pineal gland:2.31 peripheral nerve:- spine:1.32 retina:- eye:- artery/aorta:0.34 vein:0 lymphnode:0 peripheral blood:- spleen:0 thymus:0 bone marrow:- adipose:0.26 bone:- skin:-
RNA-seq cerebrum:0.14 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:1050.10 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:4.61 placenta:4.70 prostate:4.62 ovary:4.71 testis:4.65 heart:4.98 muscle:5.40 esophagus:4.91 stomach:4.63 intestine:5.05 colon:4.89 liver/hepato:4.81 lung:4.71 bladder:- kidney:9.16 pituitary:4.69 thyroid/parathyroid:4.32 adrenal gland:4.66 pancreas:5.82 breast:4.52 salivary:4.88
CAGE uterus:0.11 placenta:0 prostate:0 ovary:0 testis:0 heart:0 muscle:0 esophagus:0 stomach:- intestine:0 colon:0     liver/hepato:0    lung:0 bladder:0.09 kidney:6.32 pituitary:1.06 thyroid/parathyroid:0.12 adrenal gland:- pancreas:0 breast:0 salivary:0
RNA-seq uterus:- placenta:- prostate:0 ovary:0 testis:0 heart:0 muscle:0 esophagus:- stomach:- intestine:- colon:0     liver/hepato:0        lung:0    bladder:- kidney:3.16 pituitary:- thyroid/parathyroid:0 adrenal gland:0 pancreas:- breast:0 salivary:-

Gene Information

IDs

Refseq ID NM_004254
Gene ID 9376
Unigene ID Hs.266223
Probe set ID 221298_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000149452
GTEx ID ENSG00000149452

Orthologous Gene

Mouse[6]  NM_001164634, NM_001164635, NM_031194
Rat[1]  NM_031332, NM_001164635, NM_031194

Chromosomal Region

11q12.3  [62,756,626  -  62,783,311]

Gene Family (Interpro ID)

IPR020846  Major facilitator superfamily
IPR011701  Major facilitator superfamily MFS-1
IPR016196  Major facilitator superfamily, general substrate transporter
IPR004749  Organic cation transport protein

Link to Pubmed  (Pubmed ID)

10049739
11855680
11912245
12477932
12811365
14586168
14984259
15037815
15342556
15489334
15644426
15846473
16291576
16344560
16455804
16648942
16793932
17502342
17556638
17578901
17585018
18414781
19034961
19056867
19343046
19878671
19956635
20237588
21164499
21865262
21945944
22108572
22589738
23630107
23649425
23832370

Gene Ontology  (GO ID)

Biological Process

GO:0034635  glutathione transport
GO:0031427  response to methotrexate
GO:0009636  response to toxin
GO:0055085  transmembrane transport

Cellular Component

GO:0016323  basolateral plasma membrane
GO:0016021  integral to membrane
GO:0005886  plasma membrane

Molecular Function

GO:0005452  inorganic anion exchanger activity
GO:0008514  organic anion transmembrane transporter activity
GO:0005080  protein kinase C binding
GO:0015651  quaternary ammonium group transmembrane transporter activity