activin A receptor type II-like 1

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Synonym

TSR-I, TGF-B superfamily receptor type I, ALK-1, ORW2, activin A receptor type II-like 1, ALK1, Activin receptor-like kinase 1, HHT, ACVRL1, SKR3, HHT2, ACVRLK1

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:3.60 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:41.10 artery/aorta:- vein:533.20 lymphnode:- peripheral blood:18.20 spleen:18.90 thymus:12.90 bone marrow:- adipose:40.30 bone:12.80 skin:19.20
GeneChip cerebrum:4.93 cerebellum:4.83 brain stem:5.09 corpus callosum/glia:4.59 pineal gland:- peripheral nerve:4.70 spine:4.65 retina:- eye:- artery/aorta:5.32 vein:5.47 lymphnode:5.22 peripheral blood:- spleen:5.15 thymus:4.79 bone marrow:5.12 adipose:5.53 bone:- skin:5.40
CAGE cerebrum:1.73 cerebellum:- brain stem:1.84 corpus callosum/glia:1.88 pineal gland:1.70 peripheral nerve:- spine:1.42 retina:- eye:- artery/aorta:2.39 vein:2.95 lymphnode:2.75 peripheral blood:- spleen:3.05 thymus:1.12 bone marrow:- adipose:3.65 bone:- skin:-
RNA-seq cerebrum:0.07 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.11 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:3.26 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:51 prostate:214 ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:24.40    bladder:- kidney:31.20 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:65.10 salivary:-
GeneChip uterus:5.15 placenta:5.19 prostate:5.10 ovary:4.88 testis:4.70 heart:5.31 muscle:5.22 esophagus:5.01 stomach:5.17 intestine:5.41 colon:5.65 liver/hepato:4.85 lung:6.23 bladder:- kidney:5.19 pituitary:4.93 thyroid/parathyroid:4.99 adrenal gland:5.33 pancreas:5.01 breast:5.07 salivary:5.13
CAGE uterus:3.14 placenta:4.10 prostate:2.99 ovary:2.27 testis:1.34 heart:3.08 muscle:2.81 esophagus:2.92 stomach:- intestine:2.51 colon:3.22     liver/hepato:1.60    lung:4.47 bladder:2.67 kidney:3.00 pituitary:1.25 thyroid/parathyroid:2.75 adrenal gland:- pancreas:2.18 breast:3.16 salivary:2.06
RNA-seq uterus:- placenta:- prostate:2.26 ovary:0.30 testis:1.07 heart:1.87 muscle:1.41 esophagus:- stomach:- intestine:- colon:2.09     liver/hepato:0.32        lung:3.69    bladder:- kidney:2.26 pituitary:- thyroid/parathyroid:1.86 adrenal gland:2.51 pancreas:- breast:1.95 salivary:-

Gene Information

IDs

Refseq ID NM_000020
Gene ID 94
Unigene ID Hs.591026
Probe set ID 210838_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000139567
GTEx ID ENSG00000139567

Orthologous Gene

Mouse[1]  NM_009612
Rat [0]  

Chromosomal Region

12q13.13  [52,300,692  -  52,317,145]

Gene Family (Interpro ID)

IPR000333  Activin type II receptor
IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

8242742
8397373
8640225
8717052
8928814
9245985
9651680
10187774
10694922
10716993
10767348
11170071
11266516
11278302
11279102
11356828
11484689
12065756
12114496
12393874
12453878
12477932
12920067
14580334
14684682
14702039
15024723
15489334
15517393
15611116
15687131
15702480
15712270
15712271
15880681
15951295
16049014
16179574
16429404
16470589
16525724
16540754
16542389
16705692
16752392
16776339
16785228
16861286
16941203
17068149
17219009
17224686
17311849
17388964
17620321
17786384
18029348
18065769
18159113
18187665
18285823
18309101
18312453
18333754
18498373
18543223
18607909
18673552
18829861
18855162
18949376
18972447
18974388
19051722
19270816
19357124
19366699
19494318
19506300
19508727
19592636
19758997
19903896
19913121
20056902
20065063
20124460
20301525
20346360
20414677
20424473
20501893
20587022
20628086
20734064
21158752
21212415
21465483
21546842
21791611
21967607
22013081
22028876
22087763
22233626
22277251
22391627
22493445
22632830
22677372
22718755
22799562
23048070
23124896
23263486
23447486
23460919
23707512
23919827
24189493

Gene Ontology  (GO ID)

Biological Process

GO:0001525  angiogenesis
GO:0060840  artery development
GO:0008015  blood circulation
GO:0002043  blood vessel endothelial cell proliferation during sprouting angiogenesis
GO:0001955  blood vessel maturation
GO:0001974  blood vessel remodeling
GO:0030509  BMP signaling pathway
GO:0001701  in utero embryonic development
GO:0001946  lymphangiogenesis
GO:0060836  lymphatic endothelial cell differentiation
GO:0043537  negative regulation of blood vessel endothelial cell migration
GO:0007162  negative regulation of cell adhesion
GO:0030308  negative regulation of cell growth
GO:0030336  negative regulation of cell migration
GO:0008285  negative regulation of cell proliferation
GO:0045602  negative regulation of endothelial cell differentiation
GO:0010596  negative regulation of endothelial cell migration
GO:0001937  negative regulation of endothelial cell proliferation
GO:0051895  negative regulation of focal adhesion formation
GO:0030513  positive regulation of BMP signaling pathway
GO:0032332  positive regulation of chondrocyte differentiation
GO:0045603  positive regulation of endothelial cell differentiation
GO:0001938  positive regulation of endothelial cell proliferation
GO:0010862  positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0006468  protein amino acid phosphorylation
GO:0051291  protein heterooligomerization
GO:0008217  regulation of blood pressure
GO:0043535  regulation of blood vessel endothelial cell migration
GO:0006275  regulation of DNA replication
GO:0001936  regulation of endothelial cell proliferation
GO:0006355  regulation of transcription, DNA-dependent
GO:0007165  signal transduction
GO:0007179  transforming growth factor beta receptor signaling pathway
GO:0060841  venous blood vessel development
GO:0035313  wound healing, spreading of epidermal cells

Cellular Component

GO:0043025  cell soma
GO:0009986  cell surface
GO:0030425  dendrite
GO:0005887  integral to plasma membrane

Molecular Function

GO:0048185  activin binding
GO:0016361  activin receptor activity, type I
GO:0005524  ATP binding
GO:0046872  metal ion binding
GO:0005515  protein binding
GO:0019901  protein kinase binding
GO:0004674  protein serine/threonine kinase activity
GO:0004702  receptor signaling protein serine/threonine kinase activity
GO:0046332  SMAD binding
GO:0050431  transforming growth factor beta binding
GO:0005024  transforming growth factor beta receptor activity
GO:0005025  transforming growth factor beta receptor activity, type I
GO:0004675  transmembrane receptor protein serine/threonine kinase activity