small nuclear ribonucleoprotein 40kDa (U5)

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Synonym

U5 snRNP-specific 40 kDa protein, SPF38, MGC1910, hPRP8BP, PRPF8BP, 40K, FLJ41108, PRP8BP, WDR57, 38 kDa-splicing factor, SFP38, RP11-490K7.3, WD repeat domain 57 (U5 snRNP specific), Prp8-binding protein, WD repeat protein 57

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:20.10 cerebellum:12.60 brain stem:- corpus callosum/glia:29.20 pineal gland:- peripheral nerve:- spine:- retina:- eye:29.40 artery/aorta:30 vein:- lymphnode:50.60 peripheral blood:36.40 spleen:18.90 thymus:25.80 bone marrow:19.70 adipose:- bone:12.80 skin:57.60
GeneChip cerebrum:6.26 cerebellum:6.60 brain stem:6.36 corpus callosum/glia:6.43 pineal gland:- peripheral nerve:6.40 spine:6.61 retina:- eye:- artery/aorta:6.13 vein:6.45 lymphnode:6.41 peripheral blood:- spleen:6.20 thymus:6.89 bone marrow:6.59 adipose:6.48 bone:- skin:6.31
CAGE cerebrum:3.36 cerebellum:- brain stem:3.81 corpus callosum/glia:3.91 pineal gland:3.08 peripheral nerve:- spine:3.56 retina:- eye:- artery/aorta:3.16 vein:3.71 lymphnode:3.64 peripheral blood:- spleen:3.62 thymus:4.07 bone marrow:- adipose:3.55 bone:- skin:-
RNA-seq cerebrum:3.15 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:3.82 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:3.75 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:45.60 placenta:40.10 prostate:11.30 ovary:74.50 testis:38.90 heart:12.80 muscle:- esophagus:- stomach:42.50 intestine:64.80 colon:17     liver/hepato:52.80        lung:19.60    bladder:251.20 kidney:20.80 pituitary:232 thyroid/parathyroid:- adrenal gland:50.80 pancreas:8.90 breast:27.90 salivary:-
GeneChip uterus:6.47 placenta:6.31 prostate:6.47 ovary:6.47 testis:6.98 heart:6.35 muscle:6.21 esophagus:6.53 stomach:6.15 intestine:6.21 colon:6.36 liver/hepato:5.54 lung:6.24 bladder:- kidney:6.31 pituitary:6.80 thyroid/parathyroid:6.40 adrenal gland:6.40 pancreas:6.25 breast:6.42 salivary:6.42
CAGE uterus:3.63 placenta:3.42 prostate:3.54 ovary:3.77 testis:4.00 heart:3.41 muscle:3.46 esophagus:3.42 stomach:- intestine:3.17 colon:3.34     liver/hepato:3.30    lung:3.17 bladder:3.46 kidney:3.38 pituitary:3.59 thyroid/parathyroid:3.62 adrenal gland:- pancreas:2.98 breast:3.52 salivary:3.29
RNA-seq uterus:- placenta:- prostate:4.07 ovary:4.56 testis:4.50 heart:2.59 muscle:3.16 esophagus:- stomach:- intestine:- colon:3.38     liver/hepato:3.04        lung:3.53    bladder:- kidney:3.75 pituitary:- thyroid/parathyroid:3.86 adrenal gland:4.10 pancreas:- breast:3.45 salivary:-

Gene Information

IDs

Refseq ID NM_004814
Gene ID 9410
Unigene ID Hs.33962
Probe set ID 215905_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000060688
GTEx ID ENSG00000060688

Orthologous Gene

Mouse[2]  NM_025645
Rat [0]  

Chromosomal Region

1p35.2  [31,732,417  -  31,769,662]

Gene Family (Interpro ID)

IPR020472  G-protein beta WD-40 repeat, region
IPR001680  WD40 repeat
IPR019782  WD40 repeat 2
IPR019781  WD40 repeat, subgroup
IPR011046  WD40 repeat-like-containing domain
IPR017986  WD40-repeat-containing domain
IPR015943  WD40/YVTN repeat-like-containing domain

Link to Pubmed  (Pubmed ID)

2479028
9731529
9774689
10788320
11971955
11991638
12226669
12477932
15489334
15506927
16159877
16169070
16429158
16710414
16723661
17041588
17353931
18029348
18212063
19322201
19615732
20360068
21139048
21832049
21890473
21963094
22174317
22939629
22990118
23000965
23084401
23455491
23602568
24332808
24457600
24816145

Gene Ontology  (GO ID)

Biological Process

GO:0010467  gene expression
GO:0000398  nuclear mRNA splicing, via spliceosome
GO:0006396  RNA processing
GO:0008380  RNA splicing
GO:0000375  RNA splicing, via transesterification reactions

Cellular Component

GO:0071013  catalytic step 2 spliceosome
GO:0005737  cytoplasm
GO:0005730  nucleolus
GO:0005654  nucleoplasm
GO:0005634  nucleus
GO:0005732  small nucleolar ribonucleoprotein complex
GO:0005682  U5 snRNP

Molecular Function

GO:0005515  protein binding