heart and neural crest derivatives expressed 2

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Synonym

MGC125304, Thing2, HAND2, FLJ16260, Hed, dHand, dHAND, DHAND2, MGC125303, heart and neural crest derivatives expressed 2, DHAND

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:- cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip cerebrum:4.24 cerebellum:4.51 brain stem:4.34 corpus callosum/glia:4.37 pineal gland:- peripheral nerve:4.07 spine:4.01 retina:- eye:- artery/aorta:4.63 vein:4.83 lymphnode:4.10 peripheral blood:- spleen:3.99 thymus:3.64 bone marrow:4.29 adipose:4.35 bone:- skin:4.44
CAGE cerebrum:0.09 cerebellum:- brain stem:0.03 corpus callosum/glia:0.79 pineal gland:1.18 peripheral nerve:- spine:0.22 retina:- eye:- artery/aorta:4.40 vein:2.44 lymphnode:1.25 peripheral blood:- spleen:1.86 thymus:0.18 bone marrow:- adipose:1.41 bone:- skin:-
RNA-seq cerebrum:0.02 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:1.26 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.27 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:54.70 placenta:18.20 prostate:- ovary:298.10 testis:- heart:12.80 muscle:- esophagus:- stomach:- intestine:32.40 colon:33.90     liver/hepato:-        lung:4.90    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:50.80 pancreas:17.80 breast:- salivary:-
GeneChip uterus:4.69 placenta:4.63 prostate:3.86 ovary:4.69 testis:3.75 heart:4.69 muscle:4.60 esophagus:4.32 stomach:4.30 intestine:4.64 colon:4.78 liver/hepato:4.19 lung:4.25 bladder:- kidney:4.25 pituitary:4 thyroid/parathyroid:3.94 adrenal gland:4.25 pancreas:4.61 breast:4.02 salivary:4.21
CAGE uterus:4.92 placenta:5.22 prostate:3.81 ovary:3.78 testis:2.59 heart:4.88 muscle:0.94 esophagus:3.98 stomach:- intestine:3.79 colon:4.94     liver/hepato:3.14    lung:0.48 bladder:4.39 kidney:0.08 pituitary:0 thyroid/parathyroid:1.79 adrenal gland:- pancreas:2.48 breast:2.83 salivary:1.28
RNA-seq uterus:- placenta:- prostate:4.45 ovary:3.01 testis:1.91 heart:3.82 muscle:0.06 esophagus:- stomach:- intestine:- colon:5.23     liver/hepato:1.83        lung:0.33    bladder:- kidney:0.08 pituitary:- thyroid/parathyroid:1.92 adrenal gland:0.30 pancreas:- breast:0.93 salivary:-

Gene Information

IDs

Refseq ID NM_021973
Gene ID 9464
Unigene ID Hs.388245
Probe set ID 220480_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000164107
GTEx ID ENSG00000164107

Orthologous Gene

Mouse[1]  NM_010402
Rat[1]  NM_022696

Chromosomal Region

4q34.1  [174,446,120  -  174,451,380]

Gene Family (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

9500550
9878849
10189962
10924525
11076755
11812799
11994297
12477932
12858532
14506227
14636580
14702039
15351717
15486975
16280598
16467358
19008477
19348682
20386744
20634891
20819618
21241805
21350214
21431856
21527398
21890473
22323723
22505724
23000965
23449628
24210200
24265601
24745730

Gene Ontology  (GO ID)

Biological Process

GO:0007512  adult heart development
GO:0001525  angiogenesis
GO:0006915  apoptosis
GO:0003253  cardiac neural crest cell migration involved in outflow tract morphogenesis
GO:0003219  cardiac right ventricle formation
GO:0060536  cartilage morphogenesis
GO:0060982  coronary artery morphogenesis
GO:0042733  embryonic digit morphogenesis
GO:0007507  heart development
GO:0001947  heart looping
GO:0003007  heart morphogenesis
GO:0001701  in utero embryonic development
GO:0010463  mesenchymal cell proliferation
GO:0010667  negative regulation of cardiac muscle cell apoptosis
GO:0043392  negative regulation of DNA binding
GO:0045668  negative regulation of osteoblast differentiation
GO:0043433  negative regulation of transcription factor activity
GO:0014032  neural crest cell development
GO:0003357  noradrenergic neuron differentiation
GO:0042475  odontogenesis of dentine-containing tooth
GO:0060021  palate development
GO:0048935  peripheral nervous system neuron development
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0003266  regulation of second heart field cardioblast proliferation
GO:0006355  regulation of transcription, DNA-dependent
GO:0001967  suckling behavior
GO:0048485  sympathetic nervous system development
GO:0048538  thymus development
GO:0043586  tongue development

Cellular Component

GO:0000790  nuclear chromatin
GO:0043234  protein complex
GO:0005667  transcription factor complex

Molecular Function

GO:0003680  AT DNA binding
GO:0044212  DNA regulatory region binding
GO:0070888  E-box binding
GO:0005515  protein binding
GO:0046982  protein heterodimerization activity
GO:0042803  protein homodimerization activity
GO:0033613  transcription activator binding
GO:0003713  transcription coactivator activity
GO:0008134  transcription factor binding