A kinase (PRKA) anchor protein 6

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Synonym

ADAP6, AKAP100, AKAP 100, A-kinase anchor protein 100 kDa, mAKAP, Protein kinase A-anchoring protein 6, PRKA6, A kinase (PRKA) anchor protein 6, KIAA0311, A-kinase anchor protein 6, ADAP100, AKAP6

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:110.20 cerebellum:63 brain stem:- corpus callosum/glia:58.30 pineal gland:- peripheral nerve:61.30 spine:336.90 retina:355.90 eye:29.40 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:19.70 adipose:- bone:25.60 skin:38.40
GeneChip cerebrum:6.58 cerebellum:6.44 brain stem:6.95 corpus callosum/glia:6.01 pineal gland:- peripheral nerve:6.81 spine:6.17 retina:- eye:- artery/aorta:5.75 vein:5.87 lymphnode:5.10 peripheral blood:- spleen:4.92 thymus:4.50 bone marrow:5.30 adipose:5.23 bone:- skin:5.15
CAGE cerebrum:5.01 cerebellum:- brain stem:5.42 corpus callosum/glia:5.18 pineal gland:2.83 peripheral nerve:- spine:4.81 retina:- eye:- artery/aorta:3.96 vein:2.25 lymphnode:0.51 peripheral blood:- spleen:0.45 thymus:0.12 bone marrow:- adipose:2.20 bone:- skin:-
RNA-seq cerebrum:4.53 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.85 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.42 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:18.20 placenta:18.20 prostate:22.50 ovary:- testis:64.90 heart:38.30 muscle:80.40 esophagus:- stomach:- intestine:- colon:17     liver/hepato:21.10        lung:4.90    bladder:- kidney:- pituitary:116 thyroid/parathyroid:- adrenal gland:- pancreas:8.90 breast:9.30 salivary:-
GeneChip uterus:4.92 placenta:5.04 prostate:4.73 ovary:4.87 testis:5.06 heart:6.12 muscle:6.58 esophagus:5.09 stomach:5.37 intestine:5.40 colon:5.43 liver/hepato:5.18 lung:5.03 bladder:- kidney:5.35 pituitary:5.48 thyroid/parathyroid:5.19 adrenal gland:5.35 pancreas:5.47 breast:4.94 salivary:5.29
CAGE uterus:2.40 placenta:0.59 prostate:2.30 ovary:1.90 testis:3.15 heart:3.65 muscle:4.37 esophagus:2.42 stomach:- intestine:1.55 colon:1.27     liver/hepato:0.36    lung:1.60 bladder:3.39 kidney:0.82 pituitary:3.15 thyroid/parathyroid:0.73 adrenal gland:- pancreas:0 breast:1.53 salivary:1.00
RNA-seq uterus:- placenta:- prostate:2.30 ovary:0.72 testis:2.12 heart:4.43 muscle:4.62 esophagus:- stomach:- intestine:- colon:1.73     liver/hepato:0.17        lung:1.61    bladder:- kidney:1.06 pituitary:- thyroid/parathyroid:3.05 adrenal gland:1.05 pancreas:- breast:1.16 salivary:-

Gene Information

IDs

Refseq ID NM_004274
Gene ID 9472
Unigene ID Hs.509083
Probe set ID 205359_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000151320
GTEx ID ENSG00000151320

Orthologous Gene

Mouse[1]  NM_198111
Rat [0]  

Chromosomal Region

14q12  [32,798,479  -  33,300,567]

Gene Family (Interpro ID)

IPR018159  Spectrin/alpha-actinin

Link to Pubmed  (Pubmed ID)

7721854
9205841
9238861
9679148
10413680
10830164
11296225
11299204
11352932
11590243
11807172
12168954
12477932
12672969
12754202
14702039
15342556
15840729
16177794
17043677
17110338
17474147
17923693
19109240
20106966
20677014
21079607
21150319
22484155
22566634
22581228
23806656

Gene Ontology  (GO ID)

Biological Process

GO:0019933  cAMP-mediated signaling
GO:0071320  cellular response to cAMP
GO:0071345  cellular response to cytokine stimulus
GO:0030818  negative regulation of cAMP biosynthetic process
GO:0070886  positive regulation of calcineurin-NFAT signaling pathway
GO:0030307  positive regulation of cell growth
GO:0051533  positive regulation of NFAT protein import into nucleus
GO:0032514  positive regulation of protein phosphatase type 2B activity
GO:0051281  positive regulation of release of sequestered calcium ion into cytosol
GO:0060316  positive regulation of ryanodine-sensitive calcium-release channel activity
GO:0006605  protein targeting
GO:0001508  regulation of action potential
GO:0060306  regulation of membrane repolarization
GO:0010738  regulation of protein kinase A signaling cascade
GO:0010880  regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

Cellular Component

GO:0034704  calcium channel complex
GO:0005901  caveola
GO:0005737  cytoplasm
GO:0014704  intercalated disc
GO:0014701  junctional sarcoplasmic reticulum membrane
GO:0005635  nuclear envelope
GO:0031965  nuclear membrane
GO:0048471  perinuclear region of cytoplasm
GO:0016529  sarcoplasmic reticulum
GO:0030315  T-tubule

Molecular Function

GO:0008179  adenylate cyclase binding
GO:0043495  protein anchor
GO:0005515  protein binding
GO:0032947  protein complex scaffold
GO:0051018  protein kinase A binding
GO:0034237  protein kinase A regulatory subunit binding