protein phosphatase 1F (PP2C domain containing)

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Synonym

PPM1F, POPX2, CaM-kinase phosphatase, hFEM-2, Partner of PIX 2, FEM-2, CaMKPase, protein phosphatase 1F (PP2C domain containing), Protein phosphatase 1F, KIAA0015

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:88.90 cerebellum:75.60 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:61.30 spine:112.30 retina:- eye:70.50 artery/aorta:149.90 vein:266.60 lymphnode:121.30 peripheral blood:72.90 spleen:56.70 thymus:64.40 bone marrow:19.70 adipose:80.70 bone:102.40 skin:62.40
GeneChip cerebrum:6.99 cerebellum:6.75 brain stem:7.10 corpus callosum/glia:6.67 pineal gland:- peripheral nerve:7.43 spine:7.17 retina:- eye:- artery/aorta:7.18 vein:6.88 lymphnode:7.18 peripheral blood:- spleen:7.63 thymus:6.55 bone marrow:6.64 adipose:7.15 bone:- skin:7.06
CAGE cerebrum:2.95 cerebellum:- brain stem:3.00 corpus callosum/glia:2.70 pineal gland:2.93 peripheral nerve:- spine:2.99 retina:- eye:- artery/aorta:3.11 vein:3.43 lymphnode:3.07 peripheral blood:- spleen:3.90 thymus:2.34 bone marrow:- adipose:3.62 bone:- skin:-
RNA-seq cerebrum:2.01 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:3.31 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:3.55 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:182.30 placenta:98.40 prostate:56.30 ovary:74.50 testis:34.60 heart:89.40 muscle:100.50 esophagus:342.80 stomach:- intestine:- colon:59.40     liver/hepato:10.60        lung:68.40    bladder:- kidney:83.20 pituitary:- thyroid/parathyroid:327.50 adrenal gland:- pancreas:35.60 breast:18.60 salivary:-
GeneChip uterus:7.02 placenta:7.31 prostate:6.88 ovary:6.82 testis:6.52 heart:6.68 muscle:6.45 esophagus:6.87 stomach:6.67 intestine:6.77 colon:6.60 liver/hepato:6.74 lung:7.31 bladder:- kidney:6.88 pituitary:6.64 thyroid/parathyroid:6.86 adrenal gland:7.32 pancreas:6.56 breast:7.21 salivary:6.70
CAGE uterus:3.49 placenta:3.59 prostate:3.37 ovary:3.00 testis:2.70 heart:3.35 muscle:2.45 esophagus:3.28 stomach:- intestine:2.60 colon:2.87     liver/hepato:2.57    lung:3.43 bladder:3.21 kidney:2.74 pituitary:2.46 thyroid/parathyroid:2.77 adrenal gland:- pancreas:2.60 breast:3.56 salivary:2.60
RNA-seq uterus:- placenta:- prostate:2.84 ovary:2.63 testis:2.18 heart:1.96 muscle:1.07 esophagus:- stomach:- intestine:- colon:2.45     liver/hepato:1.30        lung:3.53    bladder:- kidney:2.51 pituitary:- thyroid/parathyroid:2.40 adrenal gland:3.76 pancreas:- breast:2.78 salivary:-

Gene Information

IDs

Refseq ID NM_014634
Gene ID 9647
Unigene ID Hs.112728
Probe set ID 37384_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000100034
GTEx ID ENSG00000100034

Orthologous Gene

Mouse[1]  NM_176833
Rat[1]  NM_175755

Chromosomal Region

22q11.22  [22,273,793  -  22,307,209]

Gene Family (Interpro ID)

IPR001932  Protein phosphatase 2C-related

Link to Pubmed  (Pubmed ID)

7584026
7584028
9074928
10348902
11559703
11864573
12477932
12539042
15140879
16169070
16344560
18839057
19322201
20016286
20379614
21139048
21656682
21906983
22079093
22144583
22268729
22743349
23621870
24250222

Gene Ontology  (GO ID)

Biological Process

GO:0033137  negative regulation of peptidyl-serine phosphorylation
GO:0006469  negative regulation of protein kinase activity
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0043280  positive regulation of caspase activity
GO:0010811  positive regulation of cell-substrate adhesion
GO:0050921  positive regulation of chemotaxis
GO:0010634  positive regulation of epithelial cell migration
GO:0051894  positive regulation of focal adhesion formation
GO:0010628  positive regulation of gene expression
GO:0045927  positive regulation of growth
GO:0051496  positive regulation of stress fiber formation

Cellular Component

GO:0005829  cytosol
GO:0048471  perinuclear region of cytoplasm
GO:0043234  protein complex

Molecular Function

GO:0033192  calmodulin-dependent protein phosphatase activity
GO:0046872  metal ion binding
GO:0016791  phosphatase activity
GO:0005515  protein binding
GO:0004722  protein serine/threonine phosphatase activity