Rap guanine nucleotide exchange factor (GEF) 2

 jump to detail

Synonym

RAPGEF2, Neural RAP guanine nucleotide exchange protein, Rap guanine nucleotide exchange factor 2, Rap guanine nucleotide exchange factor (GEF) 2, RA-GEF, PDZGEF1, nRap GEP, Rap-GEP, CNrasGEF, Rap GEP, DKFZP586O1422, KIAA0313, PDZ-GEF1, NRAPGEP

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:98.40 cerebellum:12.60 brain stem:- corpus callosum/glia:- pineal gland:148.30 peripheral nerve:30.70 spine:112.30 retina:118.60 eye:76.40 artery/aorta:89.90 vein:133.30 lymphnode:91 peripheral blood:36.40 spleen:18.90 thymus:38.70 bone marrow:59 adipose:- bone:25.60 skin:33.60
GeneChip cerebrum:8.52 cerebellum:8.05 brain stem:8.09 corpus callosum/glia:8.18 pineal gland:- peripheral nerve:7.69 spine:7.91 retina:- eye:- artery/aorta:7.56 vein:7.23 lymphnode:6.67 peripheral blood:- spleen:8.06 thymus:6.93 bone marrow:8.08 adipose:7.61 bone:- skin:7.40
CAGE cerebrum:2.62 cerebellum:- brain stem:2.31 corpus callosum/glia:2.36 pineal gland:2.03 peripheral nerve:- spine:1.85 retina:- eye:- artery/aorta:1.03 vein:0.79 lymphnode:0.35 peripheral blood:- spleen:1.88 thymus:0.23 bone marrow:- adipose:0.78 bone:- skin:-
RNA-seq cerebrum:4.29 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.70 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:3.37 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:72.90 placenta:83.80 prostate:22.50 ovary:74.50 testis:17.30 heart:63.90 muscle:40.20 esophagus:- stomach:42.50 intestine:- colon:84.80     liver/hepato:95        lung:44    bladder:- kidney:62.40 pituitary:116 thyroid/parathyroid:- adrenal gland:152.40 pancreas:80 breast:120.80 salivary:-
GeneChip uterus:7.59 placenta:8.36 prostate:7.75 ovary:7.39 testis:6.32 heart:7.72 muscle:7.67 esophagus:6.83 stomach:7.49 intestine:7.41 colon:6.76 liver/hepato:8.06 lung:7.79 bladder:- kidney:7.49 pituitary:7.65 thyroid/parathyroid:8.12 adrenal gland:6.78 pancreas:6.58 breast:7.41 salivary:7.70
CAGE uterus:0.69 placenta:1.27 prostate:0.62 ovary:0.26 testis:0.69 heart:1.60 muscle:1.49 esophagus:0.68 stomach:- intestine:0.66 colon:0.29     liver/hepato:0.71    lung:1.20 bladder:0.33 kidney:0.82 pituitary:1.38 thyroid/parathyroid:0.79 adrenal gland:- pancreas:0 breast:0.55 salivary:0.83
RNA-seq uterus:- placenta:- prostate:2.48 ovary:2.69 testis:2.79 heart:3.07 muscle:2.67 esophagus:- stomach:- intestine:- colon:2.74     liver/hepato:2.26        lung:3.53    bladder:- kidney:2.83 pituitary:- thyroid/parathyroid:3.25 adrenal gland:2.45 pancreas:- breast:3.42 salivary:-

Gene Information

IDs

Refseq ID NM_014247
Gene ID 9693
Unigene ID Hs.113912
Probe set ID 203097_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000109756
GTEx ID ENSG00000109756

Orthologous Gene

Mouse[1]  NM_001099624
Rat[1]  NM_001107684

Chromosomal Region

4q32.1  [160,025,330  -  160,281,321]

Gene Family (Interpro ID)

IPR000595  Cyclic nucleotide-binding
IPR018490  Cyclic nucleotide-binding-like
IPR014710  RmlC-like jelly roll fold

Link to Pubmed  (Pubmed ID)

7809086
8619474
9110174
9205841
10548487
10608844
10608883
10801446
10873669
10934204
11359771
11598133
11799111
12107413
12196628
12391161
12477932
14676191
15146197
16272156
16344560
17724123
20467438
20936779
21840392
21906983
21963094
22422452
22779921
23800469
24255178
24290981
24340059
24550385

Gene Ontology  (GO ID)

Biological Process

GO:0001568  blood vessel development
GO:0031547  brain-derived neurotrophic factor receptor signaling pathway
GO:0019933  cAMP-mediated signaling
GO:0071320  cellular response to cAMP
GO:0071321  cellular response to cGMP
GO:0021884  forebrain neuron development
GO:0000165  MAPKKK cascade
GO:0008285  negative regulation of cell proliferation
GO:0050774  negative regulation of dendrite morphogenesis
GO:0048022  negative regulation of melanin biosynthetic process
GO:0043950  positive regulation of cAMP-mediated signaling
GO:0070374  positive regulation of ERK1 and ERK2 cascade
GO:0010976  positive regulation of neuron projection development
GO:0045860  positive regulation of protein kinase activity
GO:0032854  positive regulation of Rap GTPase activity
GO:0032320  positive regulation of Ras GTPase activity
GO:0048167  regulation of synaptic plasticity
GO:0007264  small GTPase mediated signal transduction
GO:0021591  ventricular system development

Cellular Component

GO:0043025  cell soma
GO:0005911  cell-cell junction
GO:0005737  cytoplasm
GO:0005887  integral to plasma membrane
GO:0005770  late endosome
GO:0016020  membrane
GO:0043005  neuron projection
GO:0048471  perinuclear region of cytoplasm
GO:0005886  plasma membrane
GO:0043234  protein complex
GO:0045202  synapse

Molecular Function

GO:0031697  beta-1 adrenergic receptor binding
GO:0005509  calcium ion binding
GO:0030552  cAMP binding
GO:0030553  cGMP binding
GO:0019992  diacylglycerol binding
GO:0030165  PDZ domain binding
GO:0005515  protein binding
GO:0019901  protein kinase binding
GO:0046582  Rap GTPase activator activity
GO:0017034  Rap guanyl-nucleotide exchange factor activity
GO:0005088  Ras guanyl-nucleotide exchange factor activity
GO:0004871  signal transducer activity
GO:0050699  WW domain binding