histone deacetylase 4

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Synonym

histone deacetylase 4, Histone deacetylase 4, HD4, KIAA0288, HDAC4, HDAC-A, HDACA, HA6116

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:125.60 cerebellum:75.60 brain stem:- corpus callosum/glia:29.20 pineal gland:296.70 peripheral nerve:122.70 spine:- retina:- eye:58.80 artery/aorta:329.70 vein:66.60 lymphnode:131.40 peripheral blood:54.70 spleen:75.60 thymus:38.70 bone marrow:19.70 adipose:80.70 bone:12.80 skin:24
GeneChip cerebrum:5.99 cerebellum:6 brain stem:5.72 corpus callosum/glia:6.03 pineal gland:- peripheral nerve:6.14 spine:5.87 retina:- eye:- artery/aorta:5.94 vein:5.25 lymphnode:5.58 peripheral blood:- spleen:5.71 thymus:7.27 bone marrow:5.77 adipose:5.41 bone:- skin:6.13
CAGE cerebrum:2.63 cerebellum:- brain stem:2.74 corpus callosum/glia:2.80 pineal gland:2.44 peripheral nerve:- spine:2.62 retina:- eye:- artery/aorta:2.68 vein:3.03 lymphnode:2.59 peripheral blood:- spleen:2.66 thymus:3.18 bone marrow:- adipose:3.10 bone:- skin:-
RNA-seq cerebrum:1.93 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:1.72 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:1.40 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:127.60 placenta:94.70 prostate:22.50 ovary:111.80 testis:160.10 heart:191.60 muscle:40.20 esophagus:685.60 stomach:127.50 intestine:64.80 colon:67.80     liver/hepato:116.10        lung:97.80    bladder:- kidney:83.20 pituitary:116 thyroid/parathyroid:- adrenal gland:457.10 pancreas:97.80 breast:65.10 salivary:328.40
GeneChip uterus:6.44 placenta:4.30 prostate:6.33 ovary:6.37 testis:5.75 heart:5.30 muscle:7.57 esophagus:5.94 stomach:5.90 intestine:6.06 colon:6.14 liver/hepato:4.58 lung:5.07 bladder:- kidney:5.44 pituitary:6.55 thyroid/parathyroid:6.07 adrenal gland:6.38 pancreas:4.98 breast:5.87 salivary:4.68
CAGE uterus:3.49 placenta:2.20 prostate:3.15 ovary:2.94 testis:3.41 heart:2.40 muscle:4.52 esophagus:3.02 stomach:- intestine:2.83 colon:3.27     liver/hepato:2.19    lung:2.69 bladder:3.34 kidney:2.14 pituitary:3.00 thyroid/parathyroid:2.55 adrenal gland:- pancreas:2.66 breast:2.53 salivary:2.31
RNA-seq uterus:- placenta:- prostate:2.68 ovary:2.20 testis:2.08 heart:1.46 muscle:4.19 esophagus:- stomach:- intestine:- colon:2.75     liver/hepato:1.01        lung:1.27    bladder:- kidney:1.54 pituitary:- thyroid/parathyroid:2.08 adrenal gland:1.62 pancreas:- breast:1.73 salivary:-

Gene Information

IDs

Refseq ID NM_006037
Gene ID 9759
Unigene ID Hs.205163
Probe set ID 204225_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000068024
GTEx ID ENSG00000068024

Orthologous Gene

Mouse[1]  NM_207225
Rat[1]  NM_207225

Chromosomal Region

2q37.3  [239,969,864  -  240,323,348]

Gene Family (Interpro ID)

IPR017320  Histone deacetylase class II, eukaryotic
IPR000286  Histone deacetylase superfamily

Link to Pubmed  (Pubmed ID)

7847374
8619474
9110174
9139815
9150131
9179496
10206986
10220385
10487761
10523670
10640275
10748098
10825153
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10958686
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12711221
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14668799
15075374
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20159555
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20383178
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21988832
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23817620
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24079712
24086512
24216484
24250222
24255178

Gene Ontology  (GO ID)

Biological Process

GO:0042113  B cell activation
GO:0030183  B cell differentiation
GO:0014898  cardiac muscle hypertrophy in response to stress
GO:0006338  chromatin remodeling
GO:0016575  histone deacetylation
GO:0070932  histone H3 deacetylation
GO:0070933  histone H4 deacetylation
GO:0006954  inflammatory response
GO:0008285  negative regulation of cell proliferation
GO:0045820  negative regulation of glycolysis
GO:0010832  negative regulation of myotube differentiation
GO:0045668  negative regulation of osteoblast differentiation
GO:0043433  negative regulation of transcription factor activity
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0007399  nervous system development
GO:0002076  osteoblast development
GO:0034983  peptidyl-lysine deacetylation
GO:0008284  positive regulation of cell proliferation
GO:0033235  positive regulation of protein sumoylation
GO:0051091  positive regulation of transcription factor activity
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0010882  regulation of cardiac muscle contraction by calcium ion signaling
GO:0043393  regulation of protein binding
GO:0014894  response to denervation involved in regulation of muscle adaptation
GO:0042493  response to drug
GO:0070555  response to interleukin-1
GO:0001501  skeletal system development
GO:0006351  transcription, DNA-dependent

Cellular Component

GO:0031672  A band
GO:0042641  actomyosin
GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0000118  histone deacetylase complex
GO:0031594  neuromuscular junction
GO:0005634  nucleus
GO:0017053  transcriptional repressor complex
GO:0030018  Z disc

Molecular Function

GO:0044212  DNA regulatory region binding
GO:0004407  histone deacetylase activity
GO:0042826  histone deacetylase binding
GO:0032041  NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0046969  NAD-dependent histone deacetylase activity (H3-K9 specific)
GO:0046970  NAD-dependent histone deacetylase activity (H4-K16 specific)
GO:0030955  potassium ion binding
GO:0005515  protein binding
GO:0033558  protein deacetylase activity
GO:0019901  protein kinase binding
GO:0043565  sequence-specific DNA binding
GO:0033613  transcription activator binding
GO:0003714  transcription corepressor activity
GO:0008134  transcription factor binding
GO:0070491  transcription repressor binding
GO:0008270  zinc ion binding