Rap guanine nucleotide exchange factor (GEF) 5

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Synonym

Repac, Related to Epac, Rap guanine nucleotide exchange factor (GEF) 5, REPAC, MR-GEF, MRGEF, GFR, Guanine nucleotide exchange factor for Rap1, M-Ras-regulated Rap GEF, Rap guanine nucleotide exchange factor 5, KIAA0277, RAPGEF5

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:2.40 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip cerebrum:9.66 cerebellum:7.77 brain stem:10.22 corpus callosum/glia:10.63 pineal gland:- peripheral nerve:8.16 spine:10.81 retina:- eye:- artery/aorta:6.87 vein:7.46 lymphnode:6.79 peripheral blood:- spleen:9.04 thymus:7.67 bone marrow:5.23 adipose:7.22 bone:- skin:6.89
CAGE cerebrum:5.03 cerebellum:- brain stem:5.90 corpus callosum/glia:6.17 pineal gland:4.63 peripheral nerve:- spine:5.79 retina:- eye:- artery/aorta:3.21 vein:3.34 lymphnode:3.38 peripheral blood:- spleen:4.80 thymus:3.67 bone marrow:- adipose:4.76 bone:- skin:-
RNA-seq cerebrum:5.44 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:3.55 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:5.20 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:7.30 prostate:- ovary:- testis:17.30 heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:41.60 pituitary:- thyroid/parathyroid:- adrenal gland:50.80 pancreas:- breast:- salivary:-
GeneChip uterus:6.29 placenta:7.44 prostate:5.97 ovary:6.46 testis:6.07 heart:6.99 muscle:5.17 esophagus:6.42 stomach:6.26 intestine:6.88 colon:6.34 liver/hepato:7.16 lung:8.62 bladder:- kidney:6.33 pituitary:6.23 thyroid/parathyroid:6.01 adrenal gland:7.27 pancreas:7.02 breast:6.76 salivary:6.38
CAGE uterus:3.35 placenta:3.83 prostate:2.89 ovary:3.02 testis:2.85 heart:3.42 muscle:2.54 esophagus:3.55 stomach:- intestine:3.87 colon:3.63     liver/hepato:3.48    lung:4.41 bladder:2.95 kidney:3.18 pituitary:2.91 thyroid/parathyroid:2.90 adrenal gland:- pancreas:3.69 breast:3.64 salivary:2.95
RNA-seq uterus:- placenta:- prostate:2.08 ovary:1.93 testis:2.52 heart:2.12 muscle:1.53 esophagus:- stomach:- intestine:- colon:3.14     liver/hepato:2.02        lung:4.31    bladder:- kidney:2.76 pituitary:- thyroid/parathyroid:2.88 adrenal gland:3.97 pancreas:- breast:2.64 salivary:-

Gene Information

IDs

Refseq ID NM_012294
Gene ID 9771
Unigene ID Hs.174768
Probe set ID 204681_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000136237
GTEx ID ENSG00000136237

Orthologous Gene

Mouse[1]  NM_175930
Rat [0]  

Chromosomal Region

7p15.3  [22,157,909  -  22,396,763]

Gene Family (Interpro ID)

IPR000591  DEP domain
IPR011991  Winged helix repressor DNA-binding

Link to Pubmed  (Pubmed ID)

9039502
10486569
10777494
10934204
12477932
12690205
15342556
15489334
15856025
17725712
17903292
20379614
21546767
21988832

Gene Ontology  (GO ID)

Biological Process

GO:0007399  nervous system development
GO:0051056  regulation of small GTPase mediated signal transduction
GO:0007264  small GTPase mediated signal transduction

Cellular Component

GO:0005634  nucleus

Molecular Function

GO:0030742  GTP-dependent protein binding
GO:0017034  Rap guanyl-nucleotide exchange factor activity
GO:0005088  Ras guanyl-nucleotide exchange factor activity