IQ motif and Sec7 domain 1

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Synonym

IQ motif and Sec7 domain-containing protein 1, KIAA0763, IQSEC1, Brefeldin-resistant Arf-GEF 2 protein, ARFGEP100, IQ motif and Sec7 domain 1, BRAG2

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:118.50 cerebellum:163.70 brain stem:- corpus callosum/glia:29.20 pineal gland:445 peripheral nerve:122.70 spine:- retina:- eye:199.80 artery/aorta:30 vein:- lymphnode:70.80 peripheral blood:127.50 spleen:56.70 thymus:90.20 bone marrow:314.90 adipose:80.70 bone:127.90 skin:43.20
GeneChip cerebrum:8.03 cerebellum:7.80 brain stem:7.91 corpus callosum/glia:7.04 pineal gland:- peripheral nerve:6.89 spine:7.17 retina:- eye:- artery/aorta:7.01 vein:6.50 lymphnode:6.95 peripheral blood:- spleen:7.31 thymus:6.26 bone marrow:6.74 adipose:6.69 bone:- skin:6.12
CAGE cerebrum:3.78 cerebellum:- brain stem:3.95 corpus callosum/glia:3.74 pineal gland:4.02 peripheral nerve:- spine:3.08 retina:- eye:- artery/aorta:3.35 vein:2.80 lymphnode:2.42 peripheral blood:- spleen:2.76 thymus:1.49 bone marrow:- adipose:2.25 bone:- skin:-
RNA-seq cerebrum:4.10 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:3.78 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:3.22 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:18.20 placenta:72.90 prostate:135.20 ovary:37.30 testis:47.60 heart:127.70 muscle:- esophagus:- stomach:63.70 intestine:32.40 colon:59.40     liver/hepato:10.60        lung:53.80    bladder:125.60 kidney:72.80 pituitary:- thyroid/parathyroid:327.50 adrenal gland:- pancreas:71.10 breast:111.50 salivary:-
GeneChip uterus:6.48 placenta:6.62 prostate:6.89 ovary:6.49 testis:6.12 heart:6.60 muscle:6.66 esophagus:5.83 stomach:6.19 intestine:6.13 colon:6.01 liver/hepato:6.93 lung:6.62 bladder:- kidney:6.49 pituitary:6.62 thyroid/parathyroid:6.12 adrenal gland:7.03 pancreas:5.61 breast:6.51 salivary:6.28
CAGE uterus:2.91 placenta:3.24 prostate:2.62 ovary:2.84 testis:2.40 heart:2.08 muscle:2.13 esophagus:2.27 stomach:- intestine:2.16 colon:2.60     liver/hepato:1.99    lung:2.58 bladder:2.69 kidney:1.97 pituitary:2.63 thyroid/parathyroid:2.23 adrenal gland:- pancreas:1.21 breast:2.74 salivary:2.22
RNA-seq uterus:- placenta:- prostate:3.17 ovary:3.61 testis:2.83 heart:3.66 muscle:2.89 esophagus:- stomach:- intestine:- colon:2.62     liver/hepato:3.54        lung:2.98    bladder:- kidney:2.79 pituitary:- thyroid/parathyroid:2.83 adrenal gland:4.06 pancreas:- breast:3.71 salivary:-

Gene Information

IDs

Refseq ID NM_001134382
Gene ID 9922
Unigene ID Hs.475506
Probe set ID 203906_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000144711
GTEx ID ENSG00000144711

Orthologous Gene

Mouse[8]  NM_001134383, NM_001134384
Rat[8]  NM_001134383, NM_001134384

Chromosomal Region

3p25.2  [12,938,719  -  13,114,617]

Gene Family (Interpro ID)

IPR001849  Pleckstrin homology

Link to Pubmed  (Pubmed ID)

8619474
9110174
9872452
11226253
12477932
15302935
15489334
16461286
16807291
17846866
18029348
18084281
19946888
20601426
20613766
21163940
21795701
21858086
21903422
21966491
22613714
22662237
22701712
22815487
23747719
24024966
24457600
24550385
24778252

Gene Ontology  (GO ID)

Biological Process

GO:0030036  actin cytoskeleton organization
GO:0032012  regulation of ARF protein signal transduction
GO:0016192  vesicle-mediated transport

Cellular Component

GO:0030054  cell junction
GO:0005737  cytoplasm
GO:0043231  intracellular membrane-bounded organelle
GO:0005730  nucleolus
GO:0005802  trans-Golgi network

Molecular Function

GO:0005086  ARF guanyl-nucleotide exchange factor activity
GO:0005543  phospholipid binding