pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1

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Synonym

C920009D07Rik, TAPP-1, Tapp1, Plekha1, AA960558, Tandem PH domain-containing protein 1, TAPP1

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:81.60 cerebellum:55.30 brain stem:63.60 corpus callosum/glia:- pineal gland:- peripheral nerve:114.70 spine:- retina:321.40 eye:243.10 artery/aorta:- vein:- lymphnode:32.40 peripheral blood:86.30 spleen:118.50 thymus:98.80 bone marrow:12.80 adipose:- bone:87.70 skin:110.80
GeneChip cerebrum:9.55 cerebellum:9.28 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:9.35 spine:9.24 retina:9.21 eye:8.94 artery/aorta:- vein:9.82 lymphnode:8.83 peripheral blood:- spleen:9.01 thymus:- bone marrow:7.17 adipose:8.87 bone:7.84 skin:9.31
CAGE cerebrum:3.92 cerebellum:- brain stem:3.76 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:3.87 retina:- eye:- artery/aorta:3.24 vein:- lymphnode:3.34 peripheral blood:- spleen:2.56 thymus:2.52 bone marrow:- adipose:- bone:2.45 skin:3.69
RNA-seq cerebrum:3.98 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:138.10 prostate:- ovary:23 testis:36.90 heart:93 muscle:- esophagus:- stomach:163.60 intestine:- colon:70.50     liver/hepato:-        lung:130.50    bladder:- kidney:96.70 pituitary:245.40 thyroid/parathyroid:- adrenal gland:- pancreas:56.30 breast:65.30 salivary:-
GeneChip uterus:8.63 placenta:9.82 prostate:7.66 ovary:8.63 testis:6.32 heart:8.93 muscle:8.53 esophagus:- stomach:8.86 intestine:9.20 colon:- liver/hepato:7.18 lung:9.86 bladder:8.67 kidney:9.09 pituitary:9.12 thyroid/parathyroid:- adrenal gland:8.06 pancreas:8.07 breast:8.67 salivary:7.50
CAGE uterus:3.22 placenta:3.95 prostate:2.73 ovary:3.18 testis:2.46 heart:- muscle:- esophagus:- stomach:3.25 intestine:3.49 colon:3.63     liver/hepato:2.20    lung:4.01 bladder:3.21 kidney:- pituitary:3.73 thyroid/parathyroid:- adrenal gland:2.83 pancreas:2.90 breast:2.83 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:1.90 esophagus:- stomach:- intestine:- colon:-     liver/hepato:2.02        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_133942
Gene ID 101476
Unigene ID Mm.323554
Probe set ID 1417965_at  [Mouse430_2]
Ensembl ID ENSMUSG00000040268

Orthologous Gene

Human[2]  NM_001001974, NM_001195608, NM_021622
Rat[1]  NM_001079894, NM_001195608, NM_021622

Chromosomal Region

-

Gene Family (Interpro ID)

IPR001849  Pleckstrin homology

Link to Pubmed  (Pubmed ID)

8889548
10349636
10922068
11042159
11076861
11217851
12466851
12477932
12666202
12904583
14610273
15489334
15872005
15908120
16141072
16141073
17143286
17967808
18799693
18973680
19056881
21204784
21267068
22777911

Gene Ontology  (GO ID)

Biological Process

GO:0008209  androgen metabolic process
GO:0050853  B cell receptor signaling pathway
GO:0070301  cellular response to hydrogen peroxide
GO:0045184  establishment of protein localization
GO:0008210  estrogen metabolic process
GO:0060325  face morphogenesis
GO:0008585  female gonad development
GO:0033327  Leydig cell differentiation
GO:0001553  luteinization
GO:0035264  multicellular organism growth
GO:0051898  negative regulation of protein kinase B signaling cascade
GO:0060021  palate development
GO:0014065  phosphoinositide 3-kinase cascade
GO:0048008  platelet-derived growth factor receptor signaling pathway
GO:0009791  post-embryonic development
GO:0031529  ruffle organization
GO:0048705  skeletal system morphogenesis
GO:0007283  spermatogenesis

Cellular Component

GO:0005737  cytoplasm
GO:0016020  membrane
GO:0005634  nucleus
GO:0005886  plasma membrane
GO:0032587  ruffle membrane

Molecular Function

GO:0008289  lipid binding
GO:0030165  PDZ domain binding
GO:0043325  phosphatidylinositol-3,4-bisphosphate binding
GO:0005543  phospholipid binding