adrenergic receptor kinase, beta 1

Synonym

G-protein-coupled receptor kinase 2, beta-adrenergic receptor kinase-1, Beta-adrenergic receptor kinase 1, beta ARK1, Adrbk1, betaARK1, beta-AR kinase-1, adrenergic receptor kinase, beta 1, beta ARK, Bark-1, Grk2, Beta-ARK-1, Adrbk-1, GRK2

normal 40 tissues
developmental tissues and primary cells（FANTOM5 CAGE）

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:86.80

cerebellum:-

brain stem:31.80

corpus callosum/glia:-

pineal gland:-

peripheral nerve:172

spine:94.60

retina:64.30

eye:53.20

artery/aorta:-

vein:-

lymphnode:108

peripheral blood:86.30

spleen:79

thymus:118.60

bone marrow:141

adipose:638.20

bone:37.60

skin:39.60

GeneChip

cerebrum:9.23

cerebellum:9.83

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:9.53

spine:9.40

retina:8.18

eye:8.33

artery/aorta:-

vein:8.29

lymphnode:10.22

peripheral blood:-

spleen:10.67

thymus:-

bone marrow:10.15

adipose:8.26

bone:9.45

skin:8.45

CAGE

cerebrum:3.54

cerebellum:-

brain stem:3.45

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:3.44

retina:-

eye:-

artery/aorta:2.22

vein:-

lymphnode:3.46

peripheral blood:-

spleen:3.52

thymus:3.81

bone marrow:-

adipose:-

bone:3.83

skin:3.09

RNA-seq

cerebrum:37.55

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:-

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:-

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:-

placenta:69

prostate:-

ovary:46

testis:-

heart:-

muscle:106.50

esophagus:-

stomach:-

intestine:-

colon:88.10

liver/hepato:36.20

lung:70.30

bladder:-

kidney:8.10

pituitary:64.60

thyroid/parathyroid:-

adrenal gland:-

pancreas:18.80

breast:94.70

salivary:108

GeneChip

uterus:8.57

placenta:8.38

prostate:8.52

ovary:8.13

testis:7.71

heart:8.85

muscle:8.51

esophagus:-

stomach:8.53

intestine:8.64

colon:-

liver/hepato:8.07

lung:8.52

bladder:8.33

kidney:8.37

pituitary:8.34

thyroid/parathyroid:-

adrenal gland:8.08

pancreas:8.65

breast:8.64

salivary:8.37

CAGE

uterus:2.45

placenta:2.70

prostate:2.73

ovary:2.13

testis:1.60

heart:-

muscle:-

esophagus:-

stomach:2.52

intestine:2.49

colon:2.85

liver/hepato:1.75

lung:3.18

bladder:2.74

kidney:-

pituitary:2.91

thyroid/parathyroid:-

adrenal gland:2.48

pancreas:2.03

breast:3.05

salivary:-

RNA-seq

uterus:-

placenta:-

prostate:-

ovary:-

testis:-

heart:-

muscle:9.35

esophagus:-

stomach:-

intestine:-

colon:-

liver/hepato:4.41

lung:-

bladder:-

kidney:-

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:-

breast:-

salivary:-

IDs

Refseq ID	NM_130863
Gene ID	110355
Unigene ID	Mm.254144
Probe set ID	1426249_at [Mouse430_2]
Ensembl ID	ENSMUSG00000024858

Orthologous Gene

Human[3]	NM_001619
Rat [0]

Chromosomal Region

Gene Family (Interpro ID)

Gene Ontology (GO ID)

Biological Process

GO:0060048	cardiac muscle contraction
GO:0002029	desensitization of G-protein coupled receptor protein signaling pathway
GO:0042699	follicle-stimulating hormone signaling pathway
GO:0007186	G-protein coupled receptor protein signaling pathway
GO:0007507	heart development
GO:0045744	negative regulation of G-protein coupled receptor protein signaling pathway
GO:0045988	negative regulation of striated muscle contraction
GO:0003108	negative regulation of the force of heart contraction by chemical signal
GO:0018105	peptidyl-serine phosphorylation
GO:0018107	peptidyl-threonine phosphorylation
GO:0016310	phosphorylation
GO:0033605	positive regulation of catecholamine secretion
GO:0006468	protein amino acid phosphorylation
GO:0031623	receptor internalization
GO:0002026	regulation of the force of heart contraction
GO:0014070	response to organic cyclic substance
GO:0006979	response to oxidative stress
GO:0007165	signal transduction
GO:0007217	tachykinin receptor signaling pathway

Cellular Component

GO:0016324	apical plasma membrane
GO:0030424	axon
GO:0016323	basolateral plasma membrane
GO:0005901	caveola
GO:0005737	cytoplasm
GO:0043198	dendritic shaft
GO:0043197	dendritic spine
GO:0016020	membrane
GO:0045202	synapse

Molecular Function

GO:0005524	ATP binding
GO:0047696	beta-adrenergic receptor kinase activity
GO:0031755	Edg-2 lysophosphatidic acid receptor binding
GO:0004703	G-protein coupled receptor kinase activity
GO:0016301	kinase activity
GO:0000166	nucleotide binding
GO:0005543	phospholipid binding
GO:0005515	protein binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups

IPR000961	AGC-kinase, C-terminal
IPR001849	Pleckstrin homology
IPR000719	Protein kinase, catalytic domain
IPR011009	Protein kinase-like domain
IPR000342	Regulator of G protein signalling
IPR016137	Regulator of G protein signalling superfamily
IPR002290	Serine/threonine-protein kinase domain
IPR017442	Serine/threonine-protein kinase-like domain
IPR001245	Tyrosine-protein kinase, catalytic domain
IPR020635	Tyrosine-protein kinase, subgroup, catalytic domain

adrenergic receptor kinase, beta 1

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function