activin A receptor, type 1B

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Synonym

ActR-IB, Activin receptor type 1B precursor, Alk4, 6820432J04, Acvr1b, activin A receptor, type 1B, Serine/threonine-protein kinase receptor R2, ActRIB, SKR2, Acvrlk4, ACTR-IB

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:64.30 cerebellum:73.70 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:267.50 spine:- retina:32.10 eye:30.40 artery/aorta:- vein:- lymphnode:248.40 peripheral blood:- spleen:52.70 thymus:79 bone marrow:- adipose:- bone:112.70 skin:7.90
GeneChip cerebrum:10.42 cerebellum:9.90 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:9.38 spine:9.15 retina:9.43 eye:9.15 artery/aorta:- vein:8.96 lymphnode:9.18 peripheral blood:- spleen:8.54 thymus:- bone marrow:8.23 adipose:8.74 bone:8.10 skin:10.24
CAGE cerebrum:3.82 cerebellum:- brain stem:3.41 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:3.15 retina:- eye:- artery/aorta:2.37 vein:- lymphnode:2.84 peripheral blood:- spleen:2.48 thymus:2.80 bone marrow:- adipose:- bone:2.66 skin:3.55
RNA-seq cerebrum:13.97 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:174.50 placenta:27.60 prostate:- ovary:34.50 testis:7.40 heart:74.40 muscle:- esophagus:- stomach:- intestine:37 colon:70.50     liver/hepato:9.10        lung:20.10    bladder:132.40 kidney:8.10 pituitary:25.80 thyroid/parathyroid:- adrenal gland:- pancreas:28.10 breast:68.60 salivary:-
GeneChip uterus:9.45 placenta:9.92 prostate:8.99 ovary:8.83 testis:7.90 heart:8.26 muscle:9.68 esophagus:- stomach:9.89 intestine:10.16 colon:- liver/hepato:7.53 lung:9.84 bladder:9.26 kidney:9.29 pituitary:8.69 thyroid/parathyroid:- adrenal gland:8.17 pancreas:9.09 breast:9.15 salivary:9.09
CAGE uterus:3.54 placenta:3.00 prostate:2.52 ovary:2.78 testis:2.85 heart:- muscle:- esophagus:- stomach:3.13 intestine:3.54 colon:3.75     liver/hepato:2.26    lung:3.59 bladder:3.23 kidney:- pituitary:2.91 thyroid/parathyroid:- adrenal gland:2.28 pancreas:3.41 breast:3.34 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:5.03 esophagus:- stomach:- intestine:- colon:-     liver/hepato:1.81        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_007395
Gene ID 11479
Unigene ID Mm.308467
Probe set ID 1433725_at  [Mouse430_2]
Ensembl ID ENSMUSG00000000532

Orthologous Gene

Human[10]  NM_004302, NM_020327, NM_020328
Rat [0]  

Chromosomal Region

-

Gene Family (Interpro ID)

IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

7577669
7639738
8889548
9012495
9512518
10349636
10479450
10922068
11042159
11076861
11217851
11358869
12466851
12477932
12514121
12520002
12666204
12782414
14610273
15277382
15342483
15485907
15963767
15963972
15976303
16115198
16127153
16141072
16141073
16344855
16477644
16537572
16564040
16602821
16845371
16885157
17913787
17936261
18029401
18039968
18287559
18799693
19520079
19716815
21191412
21267068
21731673
21852401
22056140
22202673
22267736
22796494
23034635
23109354
23152446
23342175
23918385

Gene Ontology  (GO ID)

Biological Process

GO:0032924  activin receptor signaling pathway
GO:0007166  cell surface receptor linked signal transduction
GO:0009790  embryonic development
GO:0000082  G1/S transition of mitotic cell cycle
GO:0001942  hair follicle development
GO:0001701  in utero embryonic development
GO:0007498  mesoderm development
GO:0030308  negative regulation of cell growth
GO:0018107  peptidyl-threonine phosphorylation
GO:0016310  phosphorylation
GO:0032927  positive regulation of activin receptor signaling pathway
GO:0045648  positive regulation of erythrocyte differentiation
GO:0010862  positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0046777  protein amino acid autophosphorylation
GO:0006468  protein amino acid phosphorylation
GO:0009966  regulation of signal transduction
GO:0006355  regulation of transcription, DNA-dependent
GO:0007165  signal transduction
GO:0007178  transmembrane receptor protein serine/threonine kinase signaling pathway

Cellular Component

GO:0009986  cell surface
GO:0016021  integral to membrane
GO:0005887  integral to plasma membrane
GO:0016020  membrane
GO:0005886  plasma membrane

Molecular Function

GO:0048185  activin binding
GO:0017002  activin receptor activity
GO:0016361  activin receptor activity, type I
GO:0005524  ATP binding
GO:0019838  growth factor binding
GO:0034711  inhibin binding
GO:0016301  kinase activity
GO:0046872  metal ion binding
GO:0000166  nucleotide binding
GO:0005515  protein binding
GO:0004672  protein kinase activity
GO:0004674  protein serine/threonine kinase activity
GO:0004702  receptor signaling protein serine/threonine kinase activity
GO:0046332  SMAD binding
GO:0016740  transferase activity
GO:0016772  transferase activity, transferring phosphorus-containing groups
GO:0005024  transforming growth factor beta receptor activity
GO:0004675  transmembrane receptor protein serine/threonine kinase activity
GO:0031625  ubiquitin protein ligase binding