aminolevulinic acid synthase 1

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Synonym

ALAS-H, ALAS, Alas-h, Alas-1, 5-aminolevulinate synthase, succinyl-CoA: glycine C-succinyl transferase, Delta-aminolevulinate synthase, Alas1, Delta-ALA synthetase, 5-aminolevulinic acid synthase, aminolevulinic acid synthase 1

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:92 cerebellum:18.40 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:98.80 artery/aorta:- vein:- lymphnode:10.80 peripheral blood:560.70 spleen:26.30 thymus:69.20 bone marrow:487.20 adipose:- bone:125.20 skin:47.50
GeneChip cerebrum:7 cerebellum:6.99 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:7.10 spine:7.05 retina:6.76 eye:7.07 artery/aorta:- vein:7.11 lymphnode:6.97 peripheral blood:- spleen:6.55 thymus:- bone marrow:7.30 adipose:8.85 bone:7.36 skin:7.04
CAGE cerebrum:4.09 cerebellum:- brain stem:3.95 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:4.03 retina:- eye:- artery/aorta:6.28 vein:- lymphnode:3.69 peripheral blood:- spleen:4.18 thymus:3.82 bone marrow:- adipose:- bone:5.38 skin:4.31
RNA-seq cerebrum:14.59 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:43.60 placenta:82.80 prostate:- ovary:46 testis:88.70 heart:93 muscle:35.50 esophagus:- stomach:98.20 intestine:- colon:158.60     liver/hepato:416.30        lung:130.50    bladder:- kidney:129 pituitary:51.70 thyroid/parathyroid:449.90 adrenal gland:424.40 pancreas:65.70 breast:81.60 salivary:378
GeneChip uterus:7.43 placenta:7.24 prostate:7.32 ovary:8.05 testis:7.77 heart:8.78 muscle:8.88 esophagus:- stomach:8.47 intestine:8.23 colon:- liver/hepato:9.79 lung:9.53 bladder:7.31 kidney:9.16 pituitary:6.96 thyroid/parathyroid:- adrenal gland:11.15 pancreas:6.76 breast:7.81 salivary:8.68
CAGE uterus:4.63 placenta:4.78 prostate:3.64 ovary:4.98 testis:4.73 heart:- muscle:- esophagus:- stomach:5.25 intestine:5.46 colon:5.28     liver/hepato:8.25    lung:6.21 bladder:4.07 kidney:- pituitary:3.57 thyroid/parathyroid:- adrenal gland:6.82 pancreas:3.45 breast:4.07 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:13.94 esophagus:- stomach:- intestine:- colon:-     liver/hepato:90.65        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_020559
Gene ID 11655
Unigene ID Mm.290578
Probe set ID 1455282_x_at  [Mouse430_2]
Ensembl ID ENSMUSG00000032786

Orthologous Gene

Human[2]  NM_000688, NM_199166
Rat[2]  NM_000688, NM_199166

Chromosomal Region

-

Gene Family (Interpro ID)

IPR004839  Aminotransferase, class I/II
IPR015424  Pyridoxal phosphate-dependent transferase, major domain
IPR010961  Tetrapyrrole biosynthesis, 5-aminolevulinic acid synthase

Link to Pubmed  (Pubmed ID)

2780318
10349636
10725249
11042159
11076861
11217851
11267664
11870364
12466851
12477932
12520002
12881517
14610273
14681479
15482256
15489334
16141072
16141073
16602821
16778019
17300687
17469798
17485466
18287559
18614015
18799693
18929534
19334288
19917609
20015225
21044876
21267068
21600186
22070747

Gene Ontology  (GO ID)

Biological Process

GO:0009058  biosynthetic process
GO:0006783  heme biosynthetic process
GO:0008152  metabolic process
GO:0006778  porphyrin metabolic process
GO:0033014  tetrapyrrole biosynthetic process

Cellular Component

GO:0005737  cytoplasm
GO:0005759  mitochondrial matrix
GO:0005739  mitochondrion
GO:0005634  nucleus

Molecular Function

GO:0003870  5-aminolevulinate synthase activity
GO:0003824  catalytic activity
GO:0030170  pyridoxal phosphate binding
GO:0016740  transferase activity
GO:0016746  transferase activity, transferring acyl groups