ATPase, Cu++ transporting, alpha polypeptide

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Synonym

Menkes protein, br, Mnk, brindled, Copper pump 1, Blo, I14, Atp7a, Mo, Copper-transporting ATPase 1, DXHXS1608e, MNK, blotchy, Menkes disease-associated protein homolog, ATPase, Cu++ transporting, alpha polypeptide, mottled

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:6.90 cerebellum:92.10 brain stem:95.30 corpus callosum/glia:- pineal gland:- peripheral nerve:76.40 spine:- retina:- eye:15.20 artery/aorta:337.60 vein:- lymphnode:86.40 peripheral blood:575.10 spleen:52.70 thymus:88.90 bone marrow:- adipose:- bone:25 skin:71.30
GeneChip cerebrum:6.01 cerebellum:6.22 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:7.20 spine:6.22 retina:9.15 eye:8.73 artery/aorta:- vein:8.74 lymphnode:7.69 peripheral blood:- spleen:7.59 thymus:- bone marrow:7.45 adipose:7.67 bone:7.51 skin:8.62
CAGE cerebrum:2.84 cerebellum:- brain stem:2.62 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:2.75 retina:- eye:- artery/aorta:3.43 vein:- lymphnode:4.09 peripheral blood:- spleen:2.90 thymus:3.45 bone marrow:- adipose:- bone:2.45 skin:4.25
RNA-seq cerebrum:1.22 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:43.60 placenta:41.40 prostate:61.80 ovary:34.50 testis:29.60 heart:- muscle:71 esophagus:- stomach:- intestine:- colon:17.60     liver/hepato:9.10        lung:60.30    bladder:66.20 kidney:40.30 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:56.30 breast:29.40 salivary:-
GeneChip uterus:7.94 placenta:9.01 prostate:8.87 ovary:8.05 testis:5.82 heart:6.24 muscle:7.17 esophagus:- stomach:8.19 intestine:8.19 colon:- liver/hepato:6.48 lung:8.28 bladder:7.89 kidney:7.54 pituitary:7.84 thyroid/parathyroid:- adrenal gland:9.24 pancreas:6.32 breast:7.35 salivary:7.62
CAGE uterus:3.64 placenta:3.77 prostate:3.58 ovary:3.79 testis:2.60 heart:- muscle:- esophagus:- stomach:3.45 intestine:3.82 colon:3.65     liver/hepato:2.82    lung:4.02 bladder:3.56 kidney:- pituitary:3.52 thyroid/parathyroid:- adrenal gland:4.00 pancreas:2.56 breast:2.98 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:1.21 esophagus:- stomach:- intestine:- colon:-     liver/hepato:1.69        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_009726
Gene ID 11977
Unigene ID Mm.254297
Probe set ID 1418774_a_at  [Mouse430_2]
Ensembl ID ENSMUSG00000033792

Orthologous Gene

Human[2]  NM_000052
Rat [0]  

Chromosomal Region

XD  [103,222,615  -  103,320,265]

Gene Family (Interpro ID)

IPR006403  ATPase, P type, cation/copper-transporter
IPR000695  ATPase, P-type, H+ transporting proton pump
IPR006416  ATPase, P-type, heavy metal translocating
IPR001757  ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter
IPR006122  Copper ion-binding
IPR006121  Heavy metal transport/detoxification protein
IPR001802  Mercury scavenger protein

Link to Pubmed  (Pubmed ID)

14140
17511
20889
27591
187892
205481
564942
571007
571898
573617
573618
573619
937819
1115218
1694232
1752214
1779648
1819648
1912099
2055107
2288383
2473662
2474492
2793182
2899541
3209066
3243423
3385878
3564905
3571489
3674914
3678930
4147174
4399067
4405722
4435359
4561716
4670054
4808708
4858102
5361553
5367374
5452809
5948402
6441865
6462245
6542992
6583703
6644305
6670991
6685755
6870774
7024043
7130053
7195926
7197928
7333461
7509170
7552582
7681531
7688531
7704239
7726911
7769737
7805729
7873696
7887410
7959788
8009964
8025644
8054976
8054977
8081002
8082762
8096378
8118102
8174230
8245411
8419320
8434133
8490646
8490647
8490656
8490659
8550574
8640230
8661696
8672124
8732640
8740228
8889551
8895222
8921375
9090377
9147645
9147646
9166584
9207785
9215672
9215673
9321757
9342151
9352491
9358851
9380433
9385451
9392450
9587146
9686356
9687544
9721210
9823011
9831461
10098864
10332039
10349636
10587581
10632785
10720569
11042159
11076861
11217851
11311799
11386751
11391006
11534785
12056625
12372948
12466851
12477932
12488345
12520002
12620994
12904583
13103353
13227156
13764598
14248461
14610273
15159688
15356208
15634671
15634787
16141072
16141073
16317117
16338116
16371425
16461637
16488577
16590413
16750487
17003121
17045330
17215139
17248765
17483305
17588765
17928409
17967808
18000748
18650808
18768397
18799693
19058563
19351718
19375486
19571810
19627984
19799774
19808669
19965596
20084666
20594231
20671235
20831904
20849226
21267068
21336677
21471155
21677750
21878905
22089129
22130675
22573614
22815746
22869751
22900086
23064757
23281160
23776592
23884884

Gene Ontology  (GO ID)

Biological Process

GO:0006200  ATP catabolic process
GO:0046034  ATP metabolic process
GO:0001568  blood vessel development
GO:0001974  blood vessel remodeling
GO:0051216  cartilage development
GO:0006584  catecholamine metabolic process
GO:0006812  cation transport
GO:0006878  cellular copper ion homeostasis
GO:0021954  central nervous system neuron development
GO:0021702  cerebellar Purkinje cell differentiation
GO:0030199  collagen fibril organization
GO:0060003  copper ion export
GO:0015677  copper ion import
GO:0006825  copper ion transport
GO:0048813  dendrite morphogenesis
GO:0010273  detoxification of copper ion
GO:0042417  dopamine metabolic process
GO:0048251  elastic fiber assembly
GO:0051542  elastin biosynthetic process
GO:0042414  epinephrine metabolic process
GO:0030198  extracellular matrix organization
GO:0031069  hair follicle morphogenesis
GO:0035137  hindlimb morphogenesis
GO:0006811  ion transport
GO:0007626  locomotory behavior
GO:0048286  lung alveolus development
GO:0030001  metal ion transport
GO:0007005  mitochondrion organization
GO:0048553  negative regulation of metalloenzyme activity
GO:0043524  negative regulation of neuron apoptosis
GO:0048812  neuron projection morphogenesis
GO:0042421  norepinephrine biosynthetic process
GO:0042415  norepinephrine metabolic process
GO:0018205  peptidyl-lysine modification
GO:0043473  pigmentation
GO:0043085  positive regulation of catalytic activity
GO:0048554  positive regulation of metalloenzyme activity
GO:0051353  positive regulation of oxidoreductase activity
GO:0021860  pyramidal neuron development
GO:0010468  regulation of gene expression
GO:0002082  regulation of oxidative phosphorylation
GO:0001836  release of cytochrome c from mitochondria
GO:0019430  removal of superoxide radicals
GO:0046688  response to copper ion
GO:0042428  serotonin metabolic process
GO:0043588  skin development
GO:0042093  T-helper cell differentiation
GO:0006810  transport
GO:0006568  tryptophan metabolic process
GO:0006570  tyrosine metabolic process

Cellular Component

GO:0016323  basolateral plasma membrane
GO:0031526  brush border membrane
GO:0043025  cell soma
GO:0031410  cytoplasmic vesicle
GO:0005783  endoplasmic reticulum
GO:0005794  Golgi apparatus
GO:0016021  integral to membrane
GO:0005770  late endosome
GO:0016020  membrane
GO:0043005  neuron projection
GO:0048471  perinuclear region of cytoplasm
GO:0005886  plasma membrane
GO:0030141  secretory granule
GO:0005802  trans-Golgi network
GO:0030140  trans-Golgi network transport vesicle

Molecular Function

GO:0005524  ATP binding
GO:0019829  cation-transporting ATPase activity
GO:0005507  copper ion binding
GO:0005375  copper ion transmembrane transporter activity
GO:0032767  copper-dependent protein binding
GO:0004008  copper-exporting ATPase activity
GO:0016787  hydrolase activity
GO:0046872  metal ion binding
GO:0000166  nucleotide binding
GO:0005515  protein binding
GO:0016532  superoxide dismutase copper chaperone activity