dopamine receptor 4

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Synonym

D4R, D(2C) dopamine receptor, Dopamine D4 receptor, Drd4, Drd-4, D(4) dopamine receptor, dopamine receptor 4, AW125663

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:- cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:7.60 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip cerebrum:4.81 cerebellum:5.23 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:4.80 spine:5.15 retina:8.38 eye:5.78 artery/aorta:- vein:4.88 lymphnode:5.09 peripheral blood:- spleen:4.84 thymus:- bone marrow:4.99 adipose:5.25 bone:5.19 skin:5.08
CAGE cerebrum:0.23 cerebellum:- brain stem:0.30 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:0 retina:- eye:- artery/aorta:0.14 vein:- lymphnode:0 peripheral blood:- spleen:0 thymus:0 bone marrow:- adipose:- bone:0 skin:0
RNA-seq cerebrum:0.83 cerebellum:0.83 brain stem:0.83 corpus callosum/glia:0.83 pineal gland:0.83 peripheral nerve:0.83 spine:0.83 retina:0.83 eye:0.83 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:4.78 placenta:5.49 prostate:5.34 ovary:4.57 testis:6.14 heart:5.68 muscle:5.04 esophagus:- stomach:5.19 intestine:5.05 colon:- liver/hepato:5.53 lung:4.89 bladder:5.16 kidney:5.54 pituitary:5.54 thyroid/parathyroid:- adrenal gland:4.76 pancreas:6.10 breast:5.13 salivary:5.13
CAGE uterus:0.17 placenta:1.99 prostate:0.20 ovary:0.94 testis:1.89 heart:- muscle:- esophagus:- stomach:0 intestine:0 colon:0.23     liver/hepato:0    lung:0 bladder:0 kidney:- pituitary:1.31 thyroid/parathyroid:- adrenal gland:1.07 pancreas:0 breast:4.72 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_007878
Gene ID 13491
Unigene ID Mm.410759
Probe set ID 1422829_at  [Mouse430_2]
Ensembl ID ENSMUSG00000025496

Orthologous Gene

Human[1]  NM_000797
Rat [0]  

Chromosomal Region

-

Gene Family (Interpro ID)

IPR000276  7TM GPCR, rhodopsin-like
IPR002185  Dopamine D4 receptor
IPR000929  Dopamine receptor
IPR017452  GPCR, rhodopsin-like superfamily

Link to Pubmed  (Pubmed ID)

7609622
7698326
7773285
7944879
8584230
8833147
8889548
9107680
9323127
10341260
10349636
10531457
10721710
11015197
11042159
11076861
11160501
11217851
11356863
11562449
11860516
11896146
12466851
12477932
12783155
14586460
14610273
14681479
14684868
14699433
14997010
15170825
15197646
15489334
15716360
16141072
16141073
16380537
16525059
16602821
17332066
17449106
17509542
17543035
18083900
18303015
18456309
18536704
18547251
18832154
19166506
19696961
19747903
19840852
19853629
20038975
20646063
20672519
21135234
21412225
21458500
21676039
21677750
21821099
21955919
21982372
22219295
22764243
23283341
23681253
24048828

Gene Ontology  (GO ID)

Biological Process

GO:0000187  activation of MAPK activity
GO:0008344  adult locomotory behavior
GO:0050482  arachidonic acid secretion
GO:0008306  associative learning
GO:0001662  behavioral fear response
GO:0048148  behavioral response to cocaine
GO:0007212  dopamine receptor signaling pathway
GO:0042596  fear response
GO:0007186  G-protein coupled receptor protein signaling pathway
GO:0007195  inhibition of adenylate cyclase activity by dopamine receptor signaling pathway
GO:0007194  negative regulation of adenylate cyclase activity
GO:0030818  negative regulation of cAMP biosynthetic process
GO:0050709  negative regulation of protein secretion
GO:0008355  olfactory learning
GO:0033674  positive regulation of kinase activity
GO:0060406  positive regulation of penile erection
GO:0032417  positive regulation of sodium:hydrogen antiporter activity
GO:0050848  regulation of calcium-mediated signaling
GO:0042053  regulation of dopamine metabolic process
GO:0060080  regulation of inhibitory postsynaptic membrane potential
GO:0046928  regulation of neurotransmitter secretion
GO:0050804  regulation of synaptic transmission
GO:0001975  response to amphetamine
GO:0034776  response to histamine
GO:0007614  short-term memory
GO:0007165  signal transduction
GO:0001963  synaptic transmission, dopaminergic

Cellular Component

GO:0030424  axon
GO:0005938  cell cortex
GO:0043025  cell soma
GO:0005737  cytoplasm
GO:0030425  dendrite
GO:0043197  dendritic spine
GO:0016021  integral to membrane
GO:0005887  integral to plasma membrane
GO:0016020  membrane
GO:0005886  plasma membrane
GO:0043195  terminal button
GO:0012506  vesicle membrane

Molecular Function

GO:0035240  dopamine binding
GO:0004952  dopamine receptor activity
GO:0001591  dopamine receptor activity, coupled via Gi/Go
GO:0008144  drug binding
GO:0004930  G-protein coupled receptor activity
GO:0017124  SH3 domain binding
GO:0004871  signal transducer activity