Eph receptor A3

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Synonym

Tyrosine-protein kinase receptor ETK1, Epha3, Ephrin type-A receptor 3 precursor, Hek, Etk1, MEK4, Mek4, ETK1, Tyro4, End3, Cek4, Eph receptor A3, AW492086, Hek4

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:121.60 cerebellum:36.80 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:95.50 spine:94.60 retina:96.40 eye:98.80 artery/aorta:- vein:- lymphnode:10.80 peripheral blood:43.10 spleen:26.30 thymus:19.80 bone marrow:51.30 adipose:212.70 bone:50.10 skin:126.70
GeneChip cerebrum:4.11 cerebellum:4.52 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:3.64 spine:3.41 retina:4.55 eye:3.71 artery/aorta:- vein:7.35 lymphnode:3.56 peripheral blood:- spleen:3.71 thymus:- bone marrow:3.43 adipose:3.35 bone:3.66 skin:3.51
CAGE cerebrum:3.62 cerebellum:- brain stem:2.31 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:1.76 retina:- eye:- artery/aorta:3.20 vein:- lymphnode:1.41 peripheral blood:- spleen:1.06 thymus:0.82 bone marrow:- adipose:- bone:1.02 skin:1.57
RNA-seq cerebrum:2.41 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:174.50 placenta:41.40 prostate:988.30 ovary:68.90 testis:22.20 heart:632.50 muscle:390.60 esophagus:- stomach:196.40 intestine:406.70 colon:211.50     liver/hepato:72.40        lung:-    bladder:- kidney:185.40 pituitary:64.60 thyroid/parathyroid:224.90 adrenal gland:- pancreas:403.40 breast:111 salivary:-
GeneChip uterus:3.56 placenta:3.43 prostate:4.93 ovary:4.17 testis:3.38 heart:3.37 muscle:3.47 esophagus:- stomach:3.68 intestine:3.36 colon:- liver/hepato:3.60 lung:4.44 bladder:4.46 kidney:3.37 pituitary:3.38 thyroid/parathyroid:- adrenal gland:3.76 pancreas:3.55 breast:4 salivary:4.76
CAGE uterus:1.04 placenta:0.97 prostate:1.41 ovary:2.07 testis:0 heart:- muscle:- esophagus:- stomach:2.44 intestine:0.23 colon:0.41     liver/hepato:1.12    lung:2.25 bladder:2.27 kidney:- pituitary:1.22 thyroid/parathyroid:- adrenal gland:1.55 pancreas:0.84 breast:1.20 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:0.47 esophagus:- stomach:- intestine:- colon:-     liver/hepato:1.68        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_010140
Gene ID 13837
Unigene ID Mm.197728
Probe set ID 1425575_at  [Mouse430_2]
Ensembl ID ENSMUSG00000052504

Orthologous Gene

Human[3]  NM_005233, NM_182644
Rat [0]  

Chromosomal Region

-

Gene Family (Interpro ID)

IPR001090  Ephrin receptor, ligand binding
IPR003961  Fibronectin, type III
IPR008957  Fibronectin, type III-like fold
IPR008979  Galactose-binding domain-like
IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001660  Sterile alpha motif
IPR010993  Sterile alpha motif homology
IPR013761  Sterile alpha motif-type
IPR020685  Tyrosine-protein kinase
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR016257  Tyrosine-protein kinase, ephrin receptor
IPR020933  Tyrosine-protein kinase, fibroblast growth factor receptor, conserved region
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

1281307
1657122
2025425
7522971
8108111
8552593
8812059
8889548
9267020
9883724
10349636
10495276
10559410
10929715
11042159
11076861
11114734
11217851
11222144
11403717
11439183
11493561
11748150
11756505
11793228
12124402
12217323
12466851
12477932
12528186
12684176
12971893
14585969
14681479
15142957
15145949
15254900
15258590
15517401
15778706
15788771
15820684
15892098
15944189
15996548
16107646
16141072
16141073
16185771
16380715
16446123
16491080
16547242
16602821
16774998
16829211
16910173
17039519
17046737
17145500
17698011
18287559
18403711
19168674
19247962
19505147
19542359
19576892
19769959
19914184
20112066
20436479
20473036
20655977
21135139
21150899
21267068
21465626
21791286
21862448
21966449
22103416
22171039
22275477
22465667
22627288
22811059
23615279
23749471
23892084
24038871
24117969

Gene Ontology  (GO ID)

Biological Process

GO:0006915  apoptosis
GO:0016477  cell migration
GO:0071300  cellular response to retinoic acid
GO:0003197  endocardial cushion development
GO:0048013  ephrin receptor signaling pathway
GO:0008045  motor axon guidance
GO:0016310  phosphorylation
GO:0010976  positive regulation of neuron projection development
GO:0006468  protein amino acid phosphorylation
GO:0032956  regulation of actin cytoskeleton organization
GO:0010717  regulation of epithelial to mesenchymal transition
GO:0051893  regulation of focal adhesion formation
GO:0070507  regulation of microtubule cytoskeleton organization
GO:0032319  regulation of Rho GTPase activity
GO:0007169  transmembrane receptor protein tyrosine kinase signaling pathway

Cellular Component

GO:0005769  early endosome
GO:0005576  extracellular region
GO:0016021  integral to membrane
GO:0005887  integral to plasma membrane
GO:0016020  membrane
GO:0005886  plasma membrane

Molecular Function

GO:0005524  ATP binding
GO:0005003  ephrin receptor activity
GO:0005004  GPI-linked ephrin receptor activity
GO:0016301  kinase activity
GO:0000166  nucleotide binding
GO:0004672  protein kinase activity
GO:0004713  protein tyrosine kinase activity
GO:0016740  transferase activity
GO:0016772  transferase activity, transferring phosphorus-containing groups
GO:0004714  transmembrane receptor protein tyrosine kinase activity