estrogen receptor 1 (alpha)

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Synonym

ER-alpha, Esr, ERalpha, ESR, AA420328, ER[a], Estrogen receptor, Estra, AU041214, ER, Estradiol receptor, Esr1, estrogen receptor 1 (alpha), ERa, Nr3a1, Estr

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:- cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:9.90 bone marrow:- adipose:- bone:- skin:-
GeneChip cerebrum:4.26 cerebellum:4.15 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:4.19 spine:4.39 retina:4.34 eye:4.52 artery/aorta:- vein:4.22 lymphnode:4.18 peripheral blood:- spleen:4.10 thymus:- bone marrow:4.50 adipose:5.93 bone:4.39 skin:4.11
CAGE cerebrum:0.71 cerebellum:- brain stem:1.35 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:2.06 retina:- eye:- artery/aorta:4.06 vein:- lymphnode:1.78 peripheral blood:- spleen:1.32 thymus:1.80 bone marrow:- adipose:- bone:2.45 skin:3.16
RNA-seq cerebrum:1.21 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:- testis:7.40 heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:7.57 placenta:4.59 prostate:4.10 ovary:6.48 testis:4.94 heart:4.55 muscle:5.24 esophagus:- stomach:4.26 intestine:4.10 colon:- liver/hepato:5.03 lung:4.03 bladder:4.28 kidney:4.96 pituitary:6.12 thyroid/parathyroid:- adrenal gland:3.87 pancreas:4.69 breast:5.02 salivary:4.53
CAGE uterus:5.92 placenta:3.84 prostate:4.01 ovary:5.16 testis:1.60 heart:- muscle:- esophagus:- stomach:0.67 intestine:1.14 colon:0.82     liver/hepato:4.15    lung:1.05 bladder:2.21 kidney:- pituitary:5.38 thyroid/parathyroid:- adrenal gland:2.57 pancreas:0 breast:3.25 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:2.38 esophagus:- stomach:- intestine:- colon:-     liver/hepato:2.28        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_007956
Gene ID 13982
Unigene ID Mm.463262
Probe set ID 1421244_at  [Mouse430_2]
Ensembl ID ENSMUSG00000019768

Orthologous Gene

Human[28]  NM_000125, NM_001122740, NM_001122741, NM_001122742
Rat[1]  NM_012689, NM_001122740, NM_001122741, NM_001122742

Chromosomal Region

-

Gene Family (Interpro ID)

IPR001723  Steroid hormone receptor
IPR013088  Zinc finger, NHR/GATA-type
IPR001628  Zinc finger, nuclear hormone receptor-type

Link to Pubmed  (Pubmed ID)

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Gene Ontology  (GO ID)

Biological Process

GO:0008209  androgen metabolic process
GO:0001547  antral ovarian follicle growth
GO:0016049  cell growth
GO:0071391  cellular response to estrogen stimulus
GO:0002064  epithelial cell development
GO:0060750  epithelial cell proliferation involved in mammary gland duct elongation
GO:0030522  intracellular receptor-mediated signaling pathway
GO:0008584  male gonad development
GO:0060749  mammary gland alveolus development
GO:0060745  mammary gland branching involved in pregnancy
GO:0010629  negative regulation of gene expression
GO:0043124  negative regulation of I-kappaB kinase/NF-kappaB cascade
GO:0045839  negative regulation of mitosis
GO:0043433  negative regulation of transcription factor activity
GO:0045742  positive regulation of epidermal growth factor receptor signaling pathway
GO:0070374  positive regulation of ERK1 and ERK2 cascade
GO:0048146  positive regulation of fibroblast proliferation
GO:0045429  positive regulation of nitric oxide biosynthetic process
GO:0051000  positive regulation of nitric-oxide synthase activity
GO:0048386  positive regulation of retinoic acid receptor signaling pathway
GO:0051091  positive regulation of transcription factor activity
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0060527  prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0060523  prostate epithelial cord elongation
GO:0042981  regulation of apoptosis
GO:0060687  regulation of branching involved in prostate gland morphogenesis
GO:0043523  regulation of neuron apoptosis
GO:0006355  regulation of transcription, DNA-dependent
GO:0032355  response to estradiol stimulus
GO:0043627  response to estrogen stimulus
GO:0060011  Sertoli cell proliferation
GO:0043401  steroid hormone mediated signaling pathway
GO:0030518  steroid hormone receptor signaling pathway
GO:0006351  transcription, DNA-dependent
GO:0060065  uterus development
GO:0060068  vagina development

Cellular Component

GO:0005737  cytoplasm
GO:0005794  Golgi apparatus
GO:0016020  membrane
GO:0044429  mitochondrial part
GO:0043005  neuron projection
GO:0005634  nucleus
GO:0043204  perikaryon
GO:0048471  perinuclear region of cytoplasm
GO:0005886  plasma membrane
GO:0043234  protein complex
GO:0030315  T-tubule
GO:0043195  terminal button

Molecular Function

GO:0008013  beta-catenin binding
GO:0003682  chromatin binding
GO:0003677  DNA binding
GO:0019899  enzyme binding
GO:0030284  estrogen receptor activity
GO:0034056  estrogen response element binding
GO:0042562  hormone binding
GO:0042802  identical protein binding
GO:0004879  ligand-dependent nuclear receptor activity
GO:0008289  lipid binding
GO:0046872  metal ion binding
GO:0005515  protein binding
GO:0032403  protein complex binding
GO:0043565  sequence-specific DNA binding
GO:0005496  steroid binding
GO:0003707  steroid hormone receptor activity
GO:0003700  transcription factor activity
GO:0008134  transcription factor binding
GO:0031798  type 1 metabotropic glutamate receptor binding
GO:0008270  zinc ion binding