coagulation factor II (thrombin) receptor

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Synonym

coagulation factor II (thrombin) receptor, Cf2r, ThrR, Thrombin receptor, Proteinase-activated receptor 1 precursor, PAR-1, Par1, AI482343, F2r, MGC28086, thrombin receptor

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:57.30 cerebellum:55.30 brain stem:31.80 corpus callosum/glia:- pineal gland:- peripheral nerve:38.20 spine:47.30 retina:- eye:- artery/aorta:168.80 vein:- lymphnode:- peripheral blood:28.80 spleen:197.50 thymus:9.90 bone marrow:179.50 adipose:- bone:37.60 skin:47.50
GeneChip cerebrum:5.97 cerebellum:5.14 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:7.43 spine:6.51 retina:6.84 eye:8.21 artery/aorta:- vein:10.97 lymphnode:7.97 peripheral blood:- spleen:8.42 thymus:- bone marrow:7.55 adipose:6.65 bone:8.02 skin:7.41
CAGE cerebrum:1.51 cerebellum:- brain stem:2.78 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:2.55 retina:- eye:- artery/aorta:3.21 vein:- lymphnode:3.54 peripheral blood:- spleen:3.57 thymus:2.68 bone marrow:- adipose:- bone:2.93 skin:2.92
RNA-seq cerebrum:1.84 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:130.90 placenta:69 prostate:- ovary:23 testis:51.70 heart:18.60 muscle:35.50 esophagus:- stomach:163.60 intestine:665.50 colon:52.90     liver/hepato:18.10        lung:60.30    bladder:- kidney:24.20 pituitary:- thyroid/parathyroid:112.50 adrenal gland:- pancreas:56.30 breast:39.20 salivary:-
GeneChip uterus:8.70 placenta:11.24 prostate:6.79 ovary:7.83 testis:5.46 heart:8.38 muscle:6.88 esophagus:- stomach:7.49 intestine:7.47 colon:- liver/hepato:8.36 lung:10.93 bladder:8.40 kidney:8.80 pituitary:7.25 thyroid/parathyroid:- adrenal gland:10.87 pancreas:5.88 breast:7.15 salivary:6.69
CAGE uterus:3.42 placenta:5.42 prostate:2.06 ovary:3.22 testis:0.45 heart:- muscle:- esophagus:- stomach:3.54 intestine:3.21 colon:3.10     liver/hepato:3.16    lung:5.39 bladder:2.97 kidney:- pituitary:3.13 thyroid/parathyroid:- adrenal gland:5.21 pancreas:2.19 breast:2.48 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:1.81 esophagus:- stomach:- intestine:- colon:-     liver/hepato:4.74        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_010169
Gene ID 14062
Unigene ID Mm.248163
Probe set ID 1450852_s_at  [Mouse430_2]
Ensembl ID ENSMUSG00000048376

Orthologous Gene

Human[2]  NM_001992
Rat [0]  

Chromosomal Region

-

Gene Family (Interpro ID)

IPR000276  7TM GPCR, rhodopsin-like
IPR017452  GPCR, rhodopsin-like superfamily
IPR002286  P2 purinoceptor
IPR003912  Protease-activated receptor
IPR000935  Thrombin receptor

Link to Pubmed  (Pubmed ID)

8291612
8621593
8632823
8661713
8678993
8702939
8784787
8828042
8889548
8972001
9358744
9457168
9722561
9918574
9931340
10085414
10349636
10591683
10662791
10922068
10952021
11042159
11076861
11120874
11154109
11217851
11433347
11533492
11730935
11850418
11855866
12370392
12466851
12477932
12598324
12869501
12918424
12954641
14559973
14573770
14576054
14610273
14980205
15031212
15304051
15345469
15457341
15475267
15489334
15582715
15707570
15723127
15743797
15818676
15855637
15858058
16107646
16141072
16141073
16391010
16428450
16434493
16602821
16710477
16973501
16990608
17027650
17095716
17122062
17363687
17397547
17397548
17431214
17544303
17596374
17623652
17893198
17962354
17965715
17967980
18000606
18036193
18268094
18305483
18347074
18353977
18398001
18474593
18490515
18757438
18802482
18987429
19012179
19036971
19079173
19162217
19350118
19401193
19442625
19625989
19639229
19687358
19706295
19815553
19841542
19941849
20008134
20067469
20142268
20152175
20215560
20223821
20413722
20436479
20559570
20945373
21074454
21149441
21187389
21267068
21591259
21677750
21859963
21907177
21940952
22034512
22306780
22407318
22521721
22610965
22771700
22811450
22952456
23032873
23062602
23113835
23202729
23391721
23467409
23625915
23637930
23647384
23739922
23814055
23832758
23982175
24015257

Gene Ontology  (GO ID)

Biological Process

GO:0006919  activation of caspase activity
GO:0000186  activation of MAPKK activity
GO:0007200  activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger
GO:0007205  activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway
GO:0007596  blood coagulation
GO:0002248  connective tissue replacement during inflammatory response
GO:0016265  death
GO:0007204  elevation of cytosolic calcium ion concentration
GO:0051482  elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)
GO:0007529  establishment of synaptic specificity at neuromuscular junction
GO:0007186  G-protein coupled receptor protein signaling pathway
GO:0007599  hemostasis
GO:0048873  homeostasis of number of cells within a tissue
GO:0006954  inflammatory response
GO:0008285  negative regulation of cell proliferation
GO:0003105  negative regulation of glomerular filtration
GO:0043524  negative regulation of neuron apoptosis
GO:0030168  platelet activation
GO:0030194  positive regulation of blood coagulation
GO:0051928  positive regulation of calcium ion transport
GO:0043280  positive regulation of caspase activity
GO:0030335  positive regulation of cell migration
GO:0008284  positive regulation of cell proliferation
GO:0032967  positive regulation of collagen biosynthetic process
GO:0070374  positive regulation of ERK1 and ERK2 cascade
GO:0046427  positive regulation of JAK-STAT cascade
GO:0043410  positive regulation of MAPKKK cascade
GO:0014068  positive regulation of phosphoinositide 3-kinase cascade
GO:0051281  positive regulation of release of sequestered calcium ion into cytosol
GO:0035025  positive regulation of Rho protein signal transduction
GO:0045987  positive regulation of smooth muscle contraction
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0045907  positive regulation of vasoconstriction
GO:0030193  regulation of blood coagulation
GO:0032651  regulation of interleukin-1 beta production
GO:0051930  regulation of sensory perception of pain
GO:0051209  release of sequestered calcium ion into cytosol
GO:0032496  response to lipopolysaccharide
GO:0009611  response to wounding
GO:0007165  signal transduction
GO:0007262  STAT protein nuclear translocation
GO:0070493  thrombin receptor signaling pathway
GO:0007260  tyrosine phosphorylation of STAT protein

Cellular Component

GO:0005901  caveola
GO:0016021  integral to membrane
GO:0016020  membrane
GO:0031594  neuromuscular junction
GO:0005886  plasma membrane
GO:0031094  platelet dense tubular network
GO:0045211  postsynaptic membrane

Molecular Function

GO:0001965  G-protein alpha-subunit binding
GO:0031681  G-protein beta-subunit binding
GO:0004930  G-protein coupled receptor activity
GO:0032795  heterotrimeric G-protein binding
GO:0005102  receptor binding
GO:0004871  signal transducer activity
GO:0015057  thrombin receptor activity