coagulation factor II (thrombin) receptor-like 1

Synonym

Par2, Coagulation factor II receptor-like 1, Gpcr11, Proteinase-activated receptor 2 precursor, G-protein coupled receptor 11, Thrombin receptor-like 1, coagulation factor II (thrombin) receptor-like 1, Gpr11, F2rl1, PAR-2, Protease-activated receptor-2

normal 40 tissues
developmental tissues and primary cells（FANTOM5 CAGE）

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:-

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:-

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:-

bone:-

skin:-

GeneChip

cerebrum:4.57

cerebellum:4.42

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:4.33

spine:4.60

retina:4.61

eye:6.03

artery/aorta:-

vein:5.38

lymphnode:6.20

peripheral blood:-

spleen:5.52

thymus:-

bone marrow:4.58

adipose:5.32

bone:4.64

skin:7.48

CAGE

cerebrum:0

cerebellum:-

brain stem:0.47

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:0

retina:-

eye:-

artery/aorta:1.32

vein:-

lymphnode:2.98

peripheral blood:-

spleen:1.32

thymus:1.69

bone marrow:-

adipose:-

bone:1.02

skin:3.98

RNA-seq

cerebrum:0.87

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:-

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:-

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:-

placenta:-

prostate:-

ovary:80.40

testis:29.60

heart:-

muscle:-

esophagus:-

stomach:-

intestine:-

colon:-

liver/hepato:-

lung:-

bladder:-

kidney:-

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:-

breast:-

salivary:-

GeneChip

uterus:5.94

placenta:7.78

prostate:6.26

ovary:4.79

testis:4.59

heart:4.93

muscle:4.73

esophagus:-

stomach:8.37

intestine:8.66

colon:-

liver/hepato:4.60

lung:6.15

bladder:5.51

kidney:6.38

pituitary:5.46

thyroid/parathyroid:-

adrenal gland:4.59

pancreas:4.97

breast:5.26

salivary:5.34

CAGE

uterus:3.13

placenta:2.85

prostate:3.15

ovary:1.19

testis:0

heart:-

muscle:-

esophagus:-

stomach:4.13

intestine:3.79

colon:3.98

liver/hepato:0.26

lung:2.83

bladder:2.35

kidney:-

pituitary:2.22

thyroid/parathyroid:-

adrenal gland:0.26

pancreas:2.03

breast:1.84

salivary:-

RNA-seq

uterus:-

placenta:-

prostate:-

ovary:-

testis:-

heart:-

muscle:0.76

esophagus:-

stomach:-

intestine:-

colon:-

liver/hepato:0.36

lung:-

bladder:-

kidney:-

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:-

breast:-

salivary:-

IDs

Refseq ID	NM_007974
Gene ID	14063
Unigene ID	Mm.161414
Probe set ID	1448931_at [Mouse430_2]
Ensembl ID	ENSMUSG00000021678

Orthologous Gene

Human[2]	NM_005242
Rat [0]

Chromosomal Region

Gene Family (Interpro ID)

IPR000276	7TM GPCR, rhodopsin-like
IPR017452	GPCR, rhodopsin-like superfamily
IPR002286	P2 purinoceptor
IPR003912	Protease-activated receptor
IPR002281	Protease-activated receptor 2

Gene Ontology (GO ID)

Biological Process

GO:0007596	blood coagulation
GO:0090195	chemokine secretion
GO:0051607	defense response to virus
GO:0007204	elevation of cytosolic calcium ion concentration
GO:0007186	G-protein coupled receptor protein signaling pathway
GO:0006954	inflammatory response
GO:0045087	innate immune response
GO:0050702	interleukin-1 beta secretion
GO:0050900	leukocyte migration
GO:0070661	leukocyte proliferation
GO:0090198	negative regulation of chemokine secretion
GO:0046329	negative regulation of JNK cascade
GO:0034140	negative regulation of toll-like receptor 3 signaling pathway
GO:0010804	negative regulation of tumor necrosis factor-mediated signaling pathway
GO:0042119	neutrophil activation
GO:0030836	positive regulation of actin filament depolymerization
GO:0030335	positive regulation of cell migration
GO:0050921	positive regulation of chemotaxis
GO:0002741	positive regulation of cytokine secretion during immune response
GO:0043311	positive regulation of eosinophil degranulation
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0003104	positive regulation of glomerular filtration
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0046330	positive regulation of JNK cascade
GO:0002690	positive regulation of leukocyte chemotaxis
GO:0070963	positive regulation of neutrophil mediated killing of gram-negative bacterium
GO:0060100	positive regulation of phagocytosis, engulfment
GO:0014068	positive regulation of phosphoinositide 3-kinase cascade
GO:0050927	positive regulation of positive chemotaxis
GO:0031274	positive regulation of pseudopodium assembly
GO:0035025	positive regulation of Rho protein signal transduction
GO:0032930	positive regulation of superoxide release
GO:0034137	positive regulation of toll-like receptor 2 signaling pathway
GO:0034141	positive regulation of toll-like receptor 3 signaling pathway
GO:0034145	positive regulation of toll-like receptor 4 signaling pathway
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0045909	positive regulation of vasodilation
GO:0030193	regulation of blood coagulation
GO:0043122	regulation of I-kappaB kinase/NF-kappaB cascade
GO:0046328	regulation of JNK cascade
GO:0007165	signal transduction
GO:0002286	T cell activation during immune response
GO:0070493	thrombin receptor signaling pathway

Cellular Component

GO:0016021	integral to membrane
GO:0005887	integral to plasma membrane
GO:0016020	membrane
GO:0005886	plasma membrane
GO:0031143	pseudopodium

Molecular Function

GO:0001965	G-protein alpha-subunit binding
GO:0031681	G-protein beta-subunit binding
GO:0004930	G-protein coupled receptor activity
GO:0032795	heterotrimeric G-protein binding
GO:0004871	signal transducer activity
GO:0015057	thrombin receptor activity

coagulation factor II (thrombin) receptor-like 1

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function