FMS-like tyrosine kinase 4

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Synonym

Flt-4, AI323512, Flt4, Tyrosine-protein kinase receptor FLT4, VEGFR-3, FMS-like tyrosine kinase 4, VEGFR3, Chy

normal 40 tissues
developmental tissues and primary cells（FANTOM5 CAGE）

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:5.20

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:19.10

spine:-

retina:-

eye:7.60

artery/aorta:-

vein:-

lymphnode:-

peripheral blood:14.40

spleen:-

thymus:9.90

bone marrow:-

adipose:-

bone:62.60

skin:-

GeneChip

cerebrum:5.13

cerebellum:5.22

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:5.20

spine:5.36

retina:5.14

eye:5.44

artery/aorta:-

vein:5.29

lymphnode:6.81

peripheral blood:-

spleen:5.33

thymus:-

bone marrow:5.94

adipose:5.31

bone:5.53

skin:5.18

CAGE

cerebrum:1.05

cerebellum:-

brain stem:1.21

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:1.28

retina:-

eye:-

artery/aorta:2.38

vein:-

lymphnode:3.20

peripheral blood:-

spleen:2.20

thymus:0.95

bone marrow:-

adipose:-

bone:2.77

skin:1.50

RNA-seq

cerebrum:1.21

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:-

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:-

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:-

placenta:-

prostate:-

ovary:-

testis:-

heart:37.20

muscle:-

esophagus:-

stomach:-

intestine:-

colon:-

liver/hepato:9.10

lung:-

bladder:-

kidney:-

pituitary:12.90

thyroid/parathyroid:-

adrenal gland:-

pancreas:18.80

breast:49

salivary:-

GeneChip

uterus:5.29

placenta:6.23

prostate:5.37

ovary:5.12

testis:5.51

heart:5.92

muscle:5.47

esophagus:-

stomach:5.46

intestine:5.35

colon:-

liver/hepato:6.10

lung:5.82

bladder:5.27

kidney:5.43

pituitary:5.44

thyroid/parathyroid:-

adrenal gland:5.32

pancreas:6

breast:5.34

salivary:5.47

CAGE

uterus:2.64

placenta:3.64

prostate:1.56

ovary:2.70

testis:0

heart:-

muscle:-

esophagus:-

stomach:1.35

intestine:2.13

colon:1.72

liver/hepato:3.52

lung:3.18

bladder:2.65

kidney:-

pituitary:2.42

thyroid/parathyroid:-

adrenal gland:3.40

pancreas:0.84

breast:1.82

salivary:-

RNA-seq

uterus:-

placenta:-

prostate:-

ovary:-

testis:-

heart:-

muscle:1.48

esophagus:-

stomach:-

intestine:-

colon:-

liver/hepato:2.61

lung:-

bladder:-

kidney:-

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:-

breast:-

salivary:-

IDs

Refseq ID	NM_008029
Gene ID	14257
Unigene ID	Mm.329100
Probe set ID	1421442_at [Mouse430_2]
Ensembl ID	ENSMUSG00000020357

Orthologous Gene

Human[2]	NM_002020, NM_182925
Rat[1]	NM_053652, NM_182925

Chromosomal Region

Gene Family (Interpro ID)

IPR000719	Protein kinase, catalytic domain
IPR011009	Protein kinase-like domain
IPR002290	Serine/threonine-protein kinase domain
IPR017442	Serine/threonine-protein kinase-like domain
IPR001245	Tyrosine-protein kinase, catalytic domain
IPR020635	Tyrosine-protein kinase, subgroup, catalytic domain
IPR009134	Tyrosine-protein kinase, vascular endothelial growth factor receptor (VEGFR), N-terminal
IPR009137	Tyrosine-protein kinase, vascular endothelial growth factor receptor 3 (VEGFR3), N-terminal

Gene Ontology (GO ID)

Biological Process

GO:0001525	angiogenesis
GO:0048514	blood vessel morphogenesis
GO:0001945	lymph vessel development
GO:0001946	lymphangiogenesis
GO:0043066	negative regulation of apoptosis
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0016310	phosphorylation
GO:0030307	positive regulation of cell growth
GO:0008284	positive regulation of cell proliferation
GO:0010595	positive regulation of endothelial cell migration
GO:0001938	positive regulation of endothelial cell proliferation
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0046330	positive regulation of JNK cascade
GO:0043410	positive regulation of MAPKKK cascade
GO:0001934	positive regulation of protein amino acid phosphorylation
GO:0090037	positive regulation of protein kinase C signaling cascade
GO:0010575	positive regulation vascular endothelial growth factor production
GO:0046777	protein amino acid autophosphorylation
GO:0006468	protein amino acid phosphorylation
GO:0060312	regulation of blood vessel remodeling
GO:0002040	sprouting angiogenesis
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0048010	vascular endothelial growth factor receptor signaling pathway
GO:0001944	vasculature development

Cellular Component

GO:0005737	cytoplasm
GO:0016021	integral to membrane
GO:0005887	integral to plasma membrane
GO:0016020	membrane
GO:0005634	nucleus
GO:0005886	plasma membrane

Molecular Function

GO:0005524	ATP binding
GO:0019838	growth factor binding
GO:0016301	kinase activity
GO:0000166	nucleotide binding
GO:0005515	protein binding
GO:0004672	protein kinase activity
GO:0019903	protein phosphatase binding
GO:0004713	protein tyrosine kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0004714	transmembrane receptor protein tyrosine kinase activity
GO:0005021	vascular endothelial growth factor receptor activity

FMS-like tyrosine kinase 4

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function