farnesyltransferase, CAAX box, alpha

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Synonym

FTA, FTase-alpha, Fnta, CAAX farnesyltransferase alpha subunit, farnesyltransferase, CAAX box, alpha, GGTase-I-alpha, Ras proteins prenyltransferase alpha

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:- cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip cerebrum:9.91 cerebellum:10.56 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:11.12 spine:11.22 retina:9.81 eye:10.16 artery/aorta:- vein:10.39 lymphnode:10 peripheral blood:- spleen:10.04 thymus:- bone marrow:9.65 adipose:10.64 bone:9.74 skin:10.50
CAGE cerebrum:3.85 cerebellum:- brain stem:4.37 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:4.47 retina:- eye:- artery/aorta:4.14 vein:- lymphnode:3.74 peripheral blood:- spleen:3.49 thymus:3.45 bone marrow:- adipose:- bone:3.71 skin:4.07
RNA-seq cerebrum:17.00 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:- testis:73.90 heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:10.48 placenta:10.12 prostate:10.09 ovary:10.45 testis:10.74 heart:10.63 muscle:10.86 esophagus:- stomach:10.28 intestine:10.03 colon:- liver/hepato:9.55 lung:10.35 bladder:10.62 kidney:10.16 pituitary:10.21 thyroid/parathyroid:- adrenal gland:10.65 pancreas:9.28 breast:10.37 salivary:9.45
CAGE uterus:3.90 placenta:3.97 prostate:3.84 ovary:3.72 testis:5.23 heart:- muscle:- esophagus:- stomach:4.10 intestine:3.74 colon:3.63     liver/hepato:3.86    lung:4.01 bladder:4.16 kidney:- pituitary:4.05 thyroid/parathyroid:- adrenal gland:4.12 pancreas:3.36 breast:3.54 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:18.68 esophagus:- stomach:- intestine:- colon:-     liver/hepato:8.00        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_008033
Gene ID 14272
Unigene ID Mm.349600
Probe set ID 1417465_at  [Mouse430_2]
Ensembl ID ENSMUSG00000015994

Orthologous Gene

Human[2]  NM_002027
Rat [0]  

Chromosomal Region

-

Gene Family (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

7590362
8678990
9545640
9606417
10349636
10842103
10922068
11042159
11076861
11217851
12466851
12477932
12520002
14610273
14622576
15489334
15782199
16141072
16141073
21267068
21677750

Gene Ontology  (GO ID)

Biological Process

GO:0043066  negative regulation of apoptosis
GO:0051771  negative regulation of nitric-oxide synthase biosynthetic process
GO:0045213  neurotransmitter receptor metabolic process
GO:0045787  positive regulation of cell cycle
GO:0008284  positive regulation of cell proliferation
GO:0090045  positive regulation of deacetylase activity
GO:0051770  positive regulation of nitric-oxide synthase biosynthetic process
GO:0090044  positive regulation of tubulin deacetylation
GO:0018343  protein farnesylation
GO:0018342  protein prenylation
GO:0010469  regulation of receptor activity
GO:0034097  response to cytokine stimulus
GO:0010035  response to inorganic substance
GO:0014070  response to organic cyclic substance

Cellular Component

GO:0005953  CAAX-protein geranylgeranyltransferase complex
GO:0005737  cytoplasm
GO:0005875  microtubule associated complex

Molecular Function

GO:0030548  acetylcholine receptor regulator activity
GO:0043014  alpha-tubulin binding
GO:0004662  CAAX-protein geranylgeranyltransferase activity
GO:0008144  drug binding
GO:0019840  isoprenoid binding
GO:0008017  microtubule binding
GO:0042277  peptide binding
GO:0004659  prenyltransferase activity
GO:0004660  protein farnesyltransferase activity
GO:0008318  protein prenyltransferase activity
GO:0004663  Rab geranylgeranyltransferase activity
GO:0030971  receptor tyrosine kinase binding
GO:0016740  transferase activity
GO:0008270  zinc ion binding