frataxin

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Synonym

Frataxin, mitochondrial precursor, FARR, Frda, X25, FA, Fxn, frataxin

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:15.60 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:32.10 eye:- artery/aorta:- vein:- lymphnode:21.60 peripheral blood:- spleen:- thymus:19.80 bone marrow:- adipose:- bone:137.80 skin:15.80
GeneChip cerebrum:6.40 cerebellum:6.56 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:6.55 spine:6.55 retina:6.59 eye:6.99 artery/aorta:- vein:6.55 lymphnode:7.04 peripheral blood:- spleen:7.05 thymus:- bone marrow:9.04 adipose:7.72 bone:8.61 skin:6.68
CAGE cerebrum:2.06 cerebellum:- brain stem:2.29 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:2.36 retina:- eye:- artery/aorta:2.84 vein:- lymphnode:2.20 peripheral blood:- spleen:3.70 thymus:2.96 bone marrow:- adipose:- bone:3.35 skin:2.43
RNA-seq cerebrum:2.97 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:27.60 prostate:- ovary:- testis:7.40 heart:37.20 muscle:35.50 esophagus:- stomach:65.50 intestine:- colon:17.60     liver/hepato:9.10        lung:-    bladder:- kidney:16.10 pituitary:- thyroid/parathyroid:112.50 adrenal gland:- pancreas:18.80 breast:13.10 salivary:-
GeneChip uterus:6.84 placenta:6.72 prostate:7.25 ovary:7.08 testis:7.02 heart:8.87 muscle:8.89 esophagus:- stomach:7.01 intestine:7.15 colon:- liver/hepato:8.64 lung:6.56 bladder:6.53 kidney:8.25 pituitary:6.95 thyroid/parathyroid:- adrenal gland:7.04 pancreas:8.03 breast:7.60 salivary:7.36
CAGE uterus:2.28 placenta:2.12 prostate:2.52 ovary:2.50 testis:3.18 heart:- muscle:- esophagus:- stomach:2.95 intestine:2.10 colon:2.73     liver/hepato:3.42    lung:2.03 bladder:2.12 kidney:- pituitary:2.32 thyroid/parathyroid:- adrenal gland:2.57 pancreas:3.04 breast:2.36 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:11.38 esophagus:- stomach:- intestine:- colon:-     liver/hepato:7.56        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_008044
Gene ID 14297
Unigene ID Mm.7319
Probe set ID 1427282_a_at  [Mouse430_2]
Ensembl ID ENSMUSG00000059363

Orthologous Gene

Human[3]  NM_000144, NM_001161706, NM_181425
Rat [0]  

Chromosomal Region

-

Gene Family (Interpro ID)

IPR017789  Frataxin
IPR001794  Frataxin, subgroup
IPR002908  Frataxin-like

Link to Pubmed  (Pubmed ID)

9241270
9331900
9405681
10349636
10767347
10900192
11042159
11054533
11076861
11175786
11217851
11852098
12140189
12466851
12477932
12880182
12925693
14610273
14651853
14985441
15028670
15170226
15233994
16141072
16141073
16278235
16442805
16919418
17322295
17404227
17597094
18045775
18614015
18621680
19154341
19376812
19629184
19805308
20799613
21267068
21397024
21863062
22052287
22113996
22394676
22447512
22736457
23039828
23169664
23671637
23886890

Gene Ontology  (GO ID)

Biological Process

GO:0007628  adult walking behavior
GO:0009060  aerobic respiration
GO:0006879  cellular iron ion homeostasis
GO:0070301  cellular response to hydrogen peroxide
GO:0009792  embryonic development ending in birth or egg hatching
GO:0006783  heme biosynthetic process
GO:0006811  ion transport
GO:0018283  iron incorporation into metallo-sulfur cluster
GO:0055072  iron ion homeostasis
GO:0016226  iron-sulfur cluster assembly
GO:0007005  mitochondrion organization
GO:0043066  negative regulation of apoptosis
GO:0040015  negative regulation of multicellular organism growth
GO:0046621  negative regulation of organ growth
GO:0090201  negative regulation of release of cytochrome c from mitochondria
GO:0055114  oxidation reduction
GO:0006119  oxidative phosphorylation
GO:0045773  positive regulation of axon extension
GO:0030307  positive regulation of cell growth
GO:0008284  positive regulation of cell proliferation
GO:0051349  positive regulation of lyase activity
GO:0048554  positive regulation of metalloenzyme activity
GO:0051353  positive regulation of oxidoreductase activity
GO:0051347  positive regulation of transferase activity
GO:0019230  proprioception
GO:0016540  protein autoprocessing
GO:0010722  regulation of ferrochelatase activity
GO:0010039  response to iron ion
GO:0006810  transport

Cellular Component

GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0005739  mitochondrion

Molecular Function

GO:0051537  2 iron, 2 sulfur cluster binding
GO:0019899  enzyme binding
GO:0008199  ferric iron binding
GO:0008198  ferrous iron binding
GO:0004322  ferroxidase activity
GO:0034986  iron chaperone activity
GO:0051536  iron-sulfur cluster binding
GO:0046872  metal ion binding
GO:0016491  oxidoreductase activity