frizzled homolog 6 (Drosophila)

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Synonym

mFz6, Fz-6, frizzled homolog 6 (Drosophila), Fzd6, Frizzled-6 precursor, Fz6

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST nodata
GeneChip cerebrum:4.96 cerebellum:5.07 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:4.71 spine:5.16 retina:4.88 eye:5.25 artery/aorta:- vein:6.39 lymphnode:5.10 peripheral blood:- spleen:4.52 thymus:- bone marrow:4.75 adipose:6.19 bone:4.79 skin:6.87
CAGE cerebrum:1.82 cerebellum:- brain stem:2.22 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:2.13 retina:- eye:- artery/aorta:2.62 vein:- lymphnode:1.94 peripheral blood:- spleen:0.52 thymus:1.85 bone marrow:- adipose:- bone:1.02 skin:3.68
RNA-seq cerebrum:1.26 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST nodata
GeneChip uterus:7.68 placenta:5.98 prostate:7.22 ovary:6.32 testis:5.17 heart:6.02 muscle:4.98 esophagus:- stomach:5.95 intestine:5.12 colon:- liver/hepato:5.38 lung:6.12 bladder:6.48 kidney:5.96 pituitary:5.90 thyroid/parathyroid:- adrenal gland:5.23 pancreas:5.62 breast:5.76 salivary:5.05
CAGE uterus:3.79 placenta:2.49 prostate:2.76 ovary:3.14 testis:1.89 heart:- muscle:- esophagus:- stomach:2.95 intestine:1.22 colon:1.11     liver/hepato:1.80    lung:3.27 bladder:3.37 kidney:- pituitary:3.08 thyroid/parathyroid:- adrenal gland:2.89 pancreas:2.33 breast:2.75 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:1.53 esophagus:- stomach:- intestine:- colon:-     liver/hepato:2.70        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_001162494
Gene ID 14368
Unigene ID -
Probe set ID 1448662_at  [Mouse430_2]
Ensembl ID ENSMUSG00000022297

Orthologous Gene

Human[3]  NM_001164615, NM_001164616, NM_003506
Rat[1]  NM_001130536, NM_001164616, NM_003506

Chromosomal Region

15B3.1  [38,837,879  -  38,869,732]

Gene Family (Interpro ID)

IPR000539  Frizzled protein
IPR020067  Frizzled-like domain
IPR017981  GPCR, family 2-like

Link to Pubmed  (Pubmed ID)

8626800
8889548
9096311
9160667
10349636
10395542
10415363
10559494
11042159
11076861
11217851
12015971
12412008
12421715
12466851
12477932
12812787
12815618
12923052
14681479
14960276
15169958
15226265
15226823
15245425
15265686
15342465
15617677
15782199
16141072
16141073
16495441
16602821
17064353
17145500
17172440
17374359
17376975
17532316
17576136
17582687
18287559
18351662
18351675
18364260
18606138
18635608
18800919
18849982
19023080
19129494
19179304
19515997
19562671
19842188
19901330
20472610
20940229
21041481
21062866
21150899
21185284
21267068
21541287
21623369
21665003
21677750
21731673
21743464
21887698
21947380
22008794
22632972
23122850
23431170
23439395
23986237
24151333
24381198
24657404

Gene Ontology  (GO ID)

Biological Process

GO:0001525  angiogenesis
GO:0007409  axonogenesis
GO:0033278  cell proliferation in midbrain
GO:0007166  cell surface receptor linked signal transduction
GO:0001736  establishment of planar polarity
GO:0007186  G-protein coupled receptor protein signaling pathway
GO:0007199  G-protein signaling, coupled to cGMP nucleotide second messenger
GO:0008406  gonad development
GO:0001942  hair follicle development
GO:0042472  inner ear morphogenesis
GO:0030901  midbrain development
GO:0007275  multicellular organismal development
GO:0043433  negative regulation of transcription factor activity
GO:0090090  negative regulation of Wnt receptor signaling pathway through beta-catenin
GO:0001843  neural tube closure
GO:0030168  platelet activation
GO:0006357  regulation of transcription from RNA polymerase II promoter
GO:0007165  signal transduction
GO:0016055  Wnt receptor signaling pathway
GO:0060070  Wnt receptor signaling pathway through beta-catenin
GO:0060071  Wnt receptor signaling pathway, planar cell polarity pathway

Cellular Component

GO:0045177  apical part of cell
GO:0016327  apicolateral plasma membrane
GO:0005737  cytoplasm
GO:0016021  integral to membrane
GO:0016020  membrane
GO:0032589  neuron projection membrane
GO:0005886  plasma membrane

Molecular Function

GO:0004930  G-protein coupled receptor activity
GO:0030165  PDZ domain binding
GO:0005515  protein binding
GO:0004871  signal transducer activity
GO:0004888  transmembrane receptor activity
GO:0031625  ubiquitin protein ligase binding
GO:0042813  Wnt receptor activity
GO:0017147  Wnt-protein binding