X-ray repair complementing defective repair in Chinese hamster cells 6

Synonym

Ku70, CTC75, Ku p70, Xrcc6, CTC box-binding factor 75 kDa subunit, ATP-dependent DNA helicase II 70 kDa subunit, G22p1, ATP-dependent DNA helicase 2 subunit 1, DNA-repair protein XRCC6, Ku autoantigen protein p70 homolog, CTCBF

normal 40 tissues
developmental tissues and primary cells（FANTOM5 CAGE）

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:38.20

cerebellum:36.80

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:57.30

spine:-

retina:64.30

eye:45.60

artery/aorta:84.40

vein:-

lymphnode:32.40

peripheral blood:129.40

spleen:39.50

thymus:276.60

bone marrow:12.80

adipose:-

bone:50.10

skin:31.70

GeneChip

cerebrum:6.47

cerebellum:6.81

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:6.78

spine:6.71

retina:7.62

eye:6.95

artery/aorta:-

vein:7.27

lymphnode:7.69

peripheral blood:-

spleen:7.43

thymus:-

bone marrow:9.19

adipose:8.24

bone:8.80

skin:6.85

CAGE

cerebrum:2.83

cerebellum:-

brain stem:2.73

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:2.48

retina:-

eye:-

artery/aorta:4.09

vein:-

lymphnode:3.34

peripheral blood:-

spleen:3.53

thymus:5.18

bone marrow:-

adipose:-

bone:3.81

skin:2.82

RNA-seq

cerebrum:2.54

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:-

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:-

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:130.90

placenta:82.80

prostate:61.80

ovary:23

testis:29.60

heart:-

muscle:35.50

esophagus:-

stomach:-

intestine:-

colon:17.60

liver/hepato:18.10

lung:70.30

bladder:-

kidney:8.10

pituitary:12.90

thyroid/parathyroid:-

adrenal gland:-

pancreas:103.20

breast:81.60

salivary:-

GeneChip

uterus:7.79

placenta:6.49

prostate:7.45

ovary:7.68

testis:7.41

heart:7.39

muscle:8.14

esophagus:-

stomach:7.14

intestine:7.25

colon:-

liver/hepato:7.49

lung:6.59

bladder:7.23

kidney:7.02

pituitary:7.23

thyroid/parathyroid:-

adrenal gland:7.91

pancreas:6.82

breast:7.70

salivary:7.36

CAGE

uterus:3.07

placenta:2.55

prostate:2.81

ovary:3.14

testis:3.31

heart:-

muscle:-

esophagus:-

stomach:3.13

intestine:2.92

colon:2.85

liver/hepato:2.76

lung:2.41

bladder:2.70

kidney:-

pituitary:3.05

thyroid/parathyroid:-

adrenal gland:3.31

pancreas:2.66

breast:3.04

salivary:-

RNA-seq

uterus:-

placenta:-

prostate:-

ovary:-

testis:-

heart:-

muscle:4.96

esophagus:-

stomach:-

intestine:-

colon:-

liver/hepato:5.23

lung:-

bladder:-

kidney:-

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:-

breast:-

salivary:-

IDs

Refseq ID	NM_010247
Gene ID	14375
Unigene ID	Mm.288809
Probe set ID	1417437_at [Mouse430_2]
Ensembl ID	ENSMUSG00000022471

Orthologous Gene

Human[1]	NM_001469
Rat[1]	NM_139080

Chromosomal Region

15E1 [81,818,265 - 81,870,515]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

GO:0071475	cellular hyperosmotic salinity response
GO:0071481	cellular response to X-ray
GO:0006310	DNA recombination
GO:0006281	DNA repair
GO:0006302	double-strand break repair
GO:0006303	double-strand break repair via nonhomologous end joining
GO:0008152	metabolic process
GO:0045892	negative regulation of transcription, DNA-dependent
GO:0050769	positive regulation of neurogenesis
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0045893	positive regulation of transcription, DNA-dependent
GO:0006355	regulation of transcription, DNA-dependent
GO:0006974	response to DNA damage stimulus
GO:0010212	response to ionizing radiation
GO:0000723	telomere maintenance
GO:0006351	transcription, DNA-dependent
GO:0033151	V(D)J recombination

Cellular Component

GO:0005694	chromosome
GO:0005737	cytoplasm
GO:0043564	Ku70:Ku80 complex
GO:0070419	nonhomologous end joining complex
GO:0005730	nucleolus
GO:0005634	nucleus
GO:0043234	protein complex
GO:0005667	transcription factor complex

Molecular Function

GO:0051575	5'-deoxyribose-5-phosphate lyase activity
GO:0005524	ATP binding
GO:0004003	ATP-dependent DNA helicase activity
GO:0003824	catalytic activity
GO:0003684	damaged DNA binding
GO:0003677	DNA binding
GO:0044212	DNA regulatory region binding
GO:0003690	double-stranded DNA binding
GO:0003691	double-stranded telomeric DNA binding
GO:0004386	helicase activity
GO:0016787	hydrolase activity
GO:0016829	lyase activity
GO:0003676	nucleic acid binding
GO:0000166	nucleotide binding
GO:0008022	protein C-terminus binding
GO:0042162	telomeric DNA binding

X-ray repair complementing defective repair in Chinese hamster cells 6

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function