growth hormone releasing hormone receptor

 jump to detail

Synonym

GRF receptor, Ghrfr, GRFR, growth hormone releasing hormone receptor, little, Grfr, Ghrhr, lit, GHRH receptor

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:- cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip cerebrum:5.80 cerebellum:6.03 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:5.73 spine:6.27 retina:6.02 eye:6.06 artery/aorta:- vein:5.91 lymphnode:5.40 peripheral blood:- spleen:5.98 thymus:- bone marrow:6.04 adipose:5.88 bone:5.77 skin:6.08
CAGE cerebrum:0 cerebellum:- brain stem:0 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:0 retina:- eye:- artery/aorta:0 vein:- lymphnode:0 peripheral blood:- spleen:0 thymus:0 bone marrow:- adipose:- bone:0 skin:0
RNA-seq nodata
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:- pituitary:51.70 thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:5.68 placenta:6.08 prostate:5.87 ovary:5.45 testis:6.13 heart:6.41 muscle:6.11 esophagus:- stomach:6.01 intestine:5.77 colon:- liver/hepato:6.23 lung:5.68 bladder:5.87 kidney:6.15 pituitary:10.88 thyroid/parathyroid:- adrenal gland:5.74 pancreas:6.84 breast:5.96 salivary:6.33
CAGE uterus:0 placenta:0 prostate:0.20 ovary:0 testis:0 heart:- muscle:- esophagus:- stomach:0 intestine:0 colon:0     liver/hepato:0    lung:0 bladder:0 kidney:- pituitary:5.34 thyroid/parathyroid:- adrenal gland:0 pancreas:0 breast:0 salivary:-
RNA-seq nodata

Gene Information

IDs

Refseq ID NM_001003685
Gene ID 14602
Unigene ID Mm.89928
Probe set ID 1427611_at  [Mouse430_2]
Ensembl ID ENSMUSG00000004654

Orthologous Gene

Human[2]  NM_000823
Rat [0]  

Chromosomal Region

-

Gene Family (Interpro ID)

IPR000832  GPCR, family 2, secretin-like
IPR001571  GPCR, family 2, vasoactive intestinal peptide receptor
IPR001771  GPCR, family 2, vasoactive intestinal peptide receptor 1
IPR017981  GPCR, family 2-like

Link to Pubmed  (Pubmed ID)

978118
1270792
1329576
1334535
1504465
1778592
2481813
2980124
3008329
6116352
6194978
6303755
6393185
7069343
7390396
7510770
7595148
7679139
7772239
7910409
8268652
8339285
8391647
8395283
8504012
8528260
8618801
8661743
8680796
8769367
8827514
8887166
9300691
9457688
9802338
10349636
10459853
10510245
10521563
10537133
10689811
10746641
10765562
10900161
11042159
11076861
11217851
11371619
11698349
11773624
12388430
12417729
12466851
12477932
12537301
12867592
12933669
12960295
14698815
14698816
14726438
15056934
15059953
15165994
15308683
15363417
15388648
15644570
15690087
15870705
15963853
16141072
16141073
16355279
16384867
16513828
16602821
16820890
17015435
17363744
17392792
17605631
18063435
18276757
18618017
19007875
19094181
19821771
20823455
21364286
22653878

Gene Ontology  (GO ID)

Biological Process

GO:0007190  activation of adenylate cyclase activity
GO:0007189  activation of adenylate cyclase activity by G-protein signaling pathway
GO:0021984  adenohypophysis development
GO:0019933  cAMP-mediated signaling
GO:0048469  cell maturation
GO:0007166  cell surface receptor linked signal transduction
GO:0032869  cellular response to insulin stimulus
GO:0008340  determination of adult lifespan
GO:0007186  G-protein coupled receptor protein signaling pathway
GO:0007188  G-protein signaling, coupled to cAMP nucleotide second messenger
GO:0030252  growth hormone secretion
GO:0042445  hormone metabolic process
GO:0007595  lactation
GO:0030879  mammary gland development
GO:0030819  positive regulation of cAMP biosynthetic process
GO:0030816  positive regulation of cAMP metabolic process
GO:0008284  positive regulation of cell proliferation
GO:0060124  positive regulation of growth hormone secretion
GO:0046887  positive regulation of hormone secretion
GO:0040018  positive regulation of multicellular organism growth
GO:0043567  regulation of insulin-like growth factor receptor signaling pathway
GO:0051246  regulation of protein metabolic process
GO:0033143  regulation of steroid hormone receptor signaling pathway
GO:0043627  response to estrogen stimulus
GO:0051384  response to glucocorticoid stimulus
GO:0032868  response to insulin stimulus
GO:0007165  signal transduction
GO:0060133  somatotropin secreting cell development
GO:0030104  water homeostasis

Cellular Component

GO:0009986  cell surface
GO:0005737  cytoplasm
GO:0016021  integral to membrane
GO:0016020  membrane
GO:0005637  nuclear inner membrane
GO:0016363  nuclear matrix
GO:0005640  nuclear outer membrane
GO:0005886  plasma membrane
GO:0030141  secretory granule

Molecular Function

GO:0004930  G-protein coupled receptor activity
GO:0019838  growth factor binding
GO:0016520  growth hormone-releasing hormone receptor activity
GO:0017046  peptide hormone binding
GO:0005515  protein binding
GO:0004871  signal transducer activity
GO:0004888  transmembrane receptor activity