guanine nucleotide binding protein (G protein), beta polypeptide 2 like 1

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Synonym

Rack1, p205, RACK1, Gnb2-rs1, Gnb2l1, Receptor for activated C kinase, GB-like, Receptor of activated protein kinase C 1, 12-3

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:326.50 cerebellum:55.30 brain stem:31.80 corpus callosum/glia:- pineal gland:773.40 peripheral nerve:496.80 spine:47.30 retina:610.70 eye:379.90 artery/aorta:168.80 vein:- lymphnode:43.20 peripheral blood:762 spleen:210.70 thymus:494 bone marrow:141 adipose:1063.60 bone:726.40 skin:403.80
GeneChip cerebrum:11.69 cerebellum:11.35 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:11.38 spine:11.58 retina:10.76 eye:11.73 artery/aorta:- vein:13.53 lymphnode:13.90 peripheral blood:- spleen:13.71 thymus:- bone marrow:13.66 adipose:12.59 bone:13.52 skin:13.28
CAGE cerebrum:4.59 cerebellum:- brain stem:4.78 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:4.57 retina:- eye:- artery/aorta:5.21 vein:- lymphnode:6.02 peripheral blood:- spleen:6.25 thymus:5.96 bone marrow:- adipose:- bone:6.04 skin:5.84
RNA-seq cerebrum:89.00 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:1614.10 placenta:925.10 prostate:957.40 ovary:436.70 testis:421.20 heart:818.50 muscle:2414.50 esophagus:- stomach:327.30 intestine:295.80 colon:951.60     liver/hepato:488.70        lung:1606.70    bladder:132.40 kidney:733.40 pituitary:594.20 thyroid/parathyroid:1012.30 adrenal gland:- pancreas:863.20 breast:992.50 salivary:755.90
GeneChip uterus:13.93 placenta:12.94 prostate:13.42 ovary:13.85 testis:10.98 heart:12.34 muscle:12.56 esophagus:- stomach:13.22 intestine:13.42 colon:- liver/hepato:12.39 lung:13.07 bladder:13.37 kidney:12.44 pituitary:13.36 thyroid/parathyroid:- adrenal gland:12.53 pancreas:13.35 breast:13.31 salivary:13.10
CAGE uterus:6.29 placenta:6.14 prostate:6.22 ovary:5.92 testis:5.15 heart:- muscle:- esophagus:- stomach:6.29 intestine:5.83 colon:6.16     liver/hepato:5.58    lung:5.70 bladder:6.13 kidney:- pituitary:5.76 thyroid/parathyroid:- adrenal gland:5.53 pancreas:7.23 breast:6.23 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:112.27 esophagus:- stomach:- intestine:- colon:-     liver/hepato:140.19        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_008143
Gene ID 14694
Unigene ID Mm.5305
Probe set ID 1455168_a_at  [Mouse430_2]
Ensembl ID ENSMUSG00000020372

Orthologous Gene

Human[1]  NM_006098
Rat [0]  

Chromosomal Region

-

Gene Family (Interpro ID)

IPR020472  G-protein beta WD-40 repeat, region
IPR001680  WD40 repeat
IPR019782  WD40 repeat 2
IPR019781  WD40 repeat, subgroup
IPR011046  WD40 repeat-like-containing domain
IPR017986  WD40-repeat-containing domain
IPR015943  WD40/YVTN repeat-like-containing domain

Link to Pubmed  (Pubmed ID)

2499885
7671812
7968370
8562047
9371744
9507200
10349636
10852913
10922068
11042159
11076861
11099474
11217851
11455435
11544199
11884618
11934885
12359736
12466851
12477932
12509514
12520002
12826667
12884273
12904583
14610273
14651920
15102471
15254245
15342947
15489334
15577927
15611085
15752734
15782199
15796907
15823555
16051595
16141072
16141073
16183862
16339032
16414032
16458891
16537572
16602821
16919471
17110338
17118337
17149700
17500595
17515463
17881279
17908799
18194455
18258429
18287559
18420585
18799693
19341783
19501643
19698770
20093473
20103773
20493699
20697350
21034621
21262816
21267068
21347310
21677750
21860413
21885037
22210188
22314363
23212600
23555900
23582786
23649778
23652202
24457600
24491534

Gene Ontology  (GO ID)

Biological Process

GO:0006919  activation of caspase activity
GO:0006915  apoptosis
GO:0007049  cell cycle
GO:0007369  gastrulation
GO:0007275  multicellular organismal development
GO:0030308  negative regulation of cell growth
GO:0050765  negative regulation of phagocytosis
GO:0051898  negative regulation of protein kinase B signaling cascade
GO:0017148  negative regulation of translation
GO:0043065  positive regulation of apoptosis
GO:0030822  positive regulation of cAMP catabolic process
GO:0030335  positive regulation of cell migration
GO:0051343  positive regulation of cyclic-nucleotide phosphodiesterase activity
GO:0043547  positive regulation of GTPase activity
GO:0032436  positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0001934  positive regulation of protein amino acid phosphorylation
GO:0032464  positive regulation of protein homooligomerization
GO:0008104  protein localization
GO:0051726  regulation of cell cycle
GO:0090003  regulation of establishment of protein localization in plasma membrane
GO:0040008  regulation of growth
GO:0006417  regulation of translation
GO:0048511  rhythmic process

Cellular Component

GO:0042995  cell projection
GO:0043025  cell soma
GO:0005737  cytoplasm
GO:0005856  cytoskeleton
GO:0030425  dendrite
GO:0016020  membrane
GO:0030496  midbody
GO:0005634  nucleus
GO:0048471  perinuclear region of cytoplasm
GO:0001891  phagocytic cup
GO:0005886  plasma membrane
GO:0015935  small ribosomal subunit

Molecular Function

GO:0008656  caspase activator activity
GO:0019899  enzyme binding
GO:0008200  ion channel inhibitor activity
GO:0005515  protein binding
GO:0005080  protein kinase C binding
GO:0019903  protein phosphatase binding
GO:0030292  protein tyrosine kinase inhibitor activity
GO:0004872  receptor activity
GO:0030971  receptor tyrosine kinase binding
GO:0042169  SH2 domain binding