G protein-coupled receptor kinase 4

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Synonym

Gprk4, A830025H08Rik, Grk4, GRK4, G protein-coupled receptor kinase GRK4, Gprk2l, GRK, G protein-coupled receptor kinase 4

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:3.50 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:47.30 retina:32.10 eye:15.20 artery/aorta:- vein:- lymphnode:- peripheral blood:14.40 spleen:- thymus:39.50 bone marrow:- adipose:- bone:12.50 skin:-
GeneChip cerebrum:3.92 cerebellum:3.84 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:3.98 spine:3.97 retina:4.19 eye:3.92 artery/aorta:- vein:3.76 lymphnode:3.79 peripheral blood:- spleen:3.76 thymus:- bone marrow:3.92 adipose:4.17 bone:3.81 skin:3.86
CAGE cerebrum:1.55 cerebellum:- brain stem:1.13 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:1.28 retina:- eye:- artery/aorta:1.40 vein:- lymphnode:1.35 peripheral blood:- spleen:1.00 thymus:1.35 bone marrow:- adipose:- bone:1.69 skin:1.75
RNA-seq cerebrum:0.87 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:130.90 placenta:- prostate:- ovary:- testis:73.90 heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:4.01 placenta:4.18 prostate:4.19 ovary:3.97 testis:9.54 heart:4.47 muscle:4.31 esophagus:- stomach:3.84 intestine:3.84 colon:- liver/hepato:4.08 lung:3.84 bladder:4.14 kidney:4.17 pituitary:3.78 thyroid/parathyroid:- adrenal gland:3.97 pancreas:3.74 breast:4 salivary:4.17
CAGE uterus:1.16 placenta:0.94 prostate:1.56 ovary:1.42 testis:5.34 heart:- muscle:- esophagus:- stomach:1.07 intestine:0.42 colon:0.70     liver/hepato:1.02    lung:1.05 bladder:1.45 kidney:- pituitary:0.70 thyroid/parathyroid:- adrenal gland:0.91 pancreas:2.03 breast:1.20 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:1.67 esophagus:- stomach:- intestine:- colon:-     liver/hepato:1.93        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_001080743
Gene ID 14772
Unigene ID Mm.117076
Probe set ID 1454152_a_at  [Mouse430_2]
Ensembl ID ENSMUSG00000052783

Orthologous Gene

Human[5]  NM_001004056, NM_001004057, NM_182982
Rat[1]  NM_022928, NM_001004057, NM_182982

Chromosomal Region

-

Gene Family (Interpro ID)

IPR000961  AGC-kinase, C-terminal
IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR000342  Regulator of G protein signalling
IPR016137  Regulator of G protein signalling superfamily
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

7919654
10349636
10506199
11042159
11076861
11152656
11217851
12466851
12477932
14610273
15994203
16141072
16141073
19556343
21267068
21677750

Gene Ontology  (GO ID)

Biological Process

GO:0002029  desensitization of G-protein coupled receptor protein signaling pathway
GO:0002031  G-protein coupled receptor internalization
GO:0016310  phosphorylation
GO:0006468  protein amino acid phosphorylation
GO:0031623  receptor internalization
GO:0007165  signal transduction

Cellular Component

GO:0043025  cell soma
GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0030425  dendrite

Molecular Function

GO:0005524  ATP binding
GO:0004703  G-protein coupled receptor kinase activity
GO:0016301  kinase activity
GO:0000166  nucleotide binding
GO:0004672  protein kinase activity
GO:0004674  protein serine/threonine kinase activity
GO:0050254  rhodopsin kinase activity
GO:0016740  transferase activity
GO:0016772  transferase activity, transferring phosphorus-containing groups