homeodomain interacting protein kinase 3

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Synonym

Homeodomain-interacting protein kinase 3, FIST, ANPK, Fas-interacting serine/threonine-protein kinase, Nuclear body-associated kinase 3, PKY, Fist3, Hipk3, homeodomain interacting protein kinase 3, FIST3, Nbak3, DYRK6

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:36.50 cerebellum:18.40 brain stem:127.10 corpus callosum/glia:- pineal gland:- peripheral nerve:76.40 spine:141.90 retina:- eye:38 artery/aorta:168.80 vein:- lymphnode:10.80 peripheral blood:28.80 spleen:26.30 thymus:49.40 bone marrow:128.20 adipose:- bone:- skin:7.90
GeneChip cerebrum:9.96 cerebellum:10.36 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:9.91 spine:9.42 retina:10.46 eye:10.78 artery/aorta:- vein:10.84 lymphnode:10.32 peripheral blood:- spleen:10.16 thymus:- bone marrow:9.97 adipose:10.99 bone:10.35 skin:10.91
CAGE cerebrum:3.24 cerebellum:- brain stem:3.15 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:3.34 retina:- eye:- artery/aorta:4.86 vein:- lymphnode:3.09 peripheral blood:- spleen:3.19 thymus:3.28 bone marrow:- adipose:- bone:3.66 skin:3.89
RNA-seq cerebrum:2.03 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:13.80 prostate:- ovary:11.50 testis:- heart:186 muscle:71 esophagus:- stomach:- intestine:- colon:-     liver/hepato:27.20        lung:-    bladder:198.50 kidney:8.10 pituitary:38.80 thyroid/parathyroid:- adrenal gland:- pancreas:75.10 breast:52.20 salivary:-
GeneChip uterus:10.23 placenta:10.51 prostate:10.61 ovary:10.83 testis:7.97 heart:11.58 muscle:12.23 esophagus:- stomach:10.13 intestine:9.98 colon:- liver/hepato:10.03 lung:11.01 bladder:11.39 kidney:10.38 pituitary:10.67 thyroid/parathyroid:- adrenal gland:11.04 pancreas:10.29 breast:11.25 salivary:10.70
CAGE uterus:3.54 placenta:3.56 prostate:3.22 ovary:3.76 testis:5.20 heart:- muscle:- esophagus:- stomach:2.73 intestine:2.79 colon:3.24     liver/hepato:3.68    lung:3.86 bladder:3.95 kidney:- pituitary:3.66 thyroid/parathyroid:- adrenal gland:3.80 pancreas:3.97 breast:3.45 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:8.49 esophagus:- stomach:- intestine:- colon:-     liver/hepato:2.70        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_010434
Gene ID 15259
Unigene ID Mm.257925
Probe set ID 1426819_at  [Mouse430_2]
Ensembl ID ENSMUSG00000027177

Orthologous Gene

Human[4]  NM_001048200, NM_005734
Rat [0]  

Chromosomal Region

2E2  [104,266,638  -  104,334,603]

Gene Family (Interpro ID)

IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

9725910
9748262
10349636
10512203
10922068
11034606
11042159
11076861
11217851
12466851
12477932
12529400
14610273
15840001
16141072
16141073
16537918
16919269
18799693
20484411
20579985
21267068
22983607

Gene Ontology  (GO ID)

Biological Process

GO:0006915  apoptosis
GO:0009299  mRNA transcription
GO:0043066  negative regulation of apoptosis
GO:0043508  negative regulation of JUN kinase activity
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0018105  peptidyl-serine phosphorylation
GO:0018107  peptidyl-threonine phosphorylation
GO:0016310  phosphorylation
GO:0043388  positive regulation of DNA binding
GO:0006468  protein amino acid phosphorylation
GO:0006355  regulation of transcription, DNA-dependent
GO:0006351  transcription, DNA-dependent

Cellular Component

GO:0005737  cytoplasm
GO:0005634  nucleus
GO:0016605  PML body

Molecular Function

GO:0005524  ATP binding
GO:0003677  DNA binding
GO:0016301  kinase activity
GO:0000166  nucleotide binding
GO:0005515  protein binding
GO:0004672  protein kinase activity
GO:0004674  protein serine/threonine kinase activity
GO:0003714  transcription corepressor activity
GO:0016740  transferase activity
GO:0016772  transferase activity, transferring phosphorus-containing groups