heat shock protein 1 (chaperonin)

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Synonym

60 kDa chaperonin, heat shock protein 1 (chaperonin), HSPD1, 60 kDa heat shock protein, mitochondrial precursor, HSP-65, CPN60, Heat shock protein 60, Mitochondrial matrix protein P1, Hsp60, Hspd1, HSP-60

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:- cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:10.80 peripheral blood:- spleen:- thymus:9.90 bone marrow:- adipose:- bone:- skin:-
GeneChip cerebrum:11.06 cerebellum:11.26 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:11.65 spine:11.35 retina:9.76 eye:10.01 artery/aorta:- vein:11.34 lymphnode:11.22 peripheral blood:- spleen:11.75 thymus:- bone marrow:11.63 adipose:11.92 bone:11.58 skin:10.99
CAGE cerebrum:4.58 cerebellum:- brain stem:4.85 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:4.85 retina:- eye:- artery/aorta:6.41 vein:- lymphnode:5.24 peripheral blood:- spleen:5.32 thymus:5.06 bone marrow:- adipose:- bone:4.93 skin:4.91
RNA-seq cerebrum:21.65 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:174.50 placenta:- prostate:- ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:11.62 placenta:11.44 prostate:11.31 ovary:12.79 testis:9.28 heart:12.24 muscle:11.78 esophagus:- stomach:12.15 intestine:12.29 colon:- liver/hepato:12.77 lung:11.44 bladder:11.01 kidney:12.94 pituitary:12 thyroid/parathyroid:- adrenal gland:12.59 pancreas:10.48 breast:11.68 salivary:10.76
CAGE uterus:5.10 placenta:5.51 prostate:5.17 ovary:5.56 testis:3.85 heart:- muscle:- esophagus:- stomach:5.07 intestine:6.07 colon:5.43     liver/hepato:6.57    lung:4.47 bladder:4.39 kidney:- pituitary:4.91 thyroid/parathyroid:- adrenal gland:6.61 pancreas:4.82 breast:5.49 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:18.96 esophagus:- stomach:- intestine:- colon:-     liver/hepato:85.92        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_010477
Gene ID 15510
Unigene ID Mm.17771
Probe set ID 1426351_at  [Mouse430_2]
Ensembl ID ENSMUSG00000025980

Orthologous Gene

Human[4]  NM_002156, NM_199440
Rat [0]  

Chromosomal Region

-

Gene Family (Interpro ID)

IPR017998  Chaperone, tailless complex polypeptide 1
IPR001844  Chaperonin Cpn60
IPR002423  Chaperonin Cpn60/TCP-1

Link to Pubmed  (Pubmed ID)

1347942
1516759
1707531
1979012
2263486
2406723
7523108
8565293
8824711
8974842
9125545
9867803
10349636
10623794
10922068
11042159
11076861
11091906
11217851
11449358
12421990
12466851
12477932
12748967
12865426
12904583
12931191
14610273
14651853
15050156
15136728
15166233
15196922
15252132
15339983
15371451
15489334
15546885
15782199
16116071
16141072
16141073
16547598
16602821
16708399
16959573
17164250
17324390
17661394
17967808
18256040
18276932
18614015
18619964
18799693
19192108
19306954
19447897
19527807
19561102
19647739
20351780
20393889
20501446
20609438
20631313
20697350
21134968
21266579
21267068
21278135
21565611
21589869
21775438
21874024
21984432
22083510
22673621
22753410
23466696
23695782
23770722
23976951
24084737
24457600
24614889

Gene Ontology  (GO ID)

Biological Process

GO:0006919  activation of caspase activity
GO:0042113  B cell activation
GO:0002368  B cell cytokine production
GO:0042100  B cell proliferation
GO:0044267  cellular protein metabolic process
GO:0051085  chaperone mediated protein folding requiring cofactor
GO:0002236  detection of misfolded protein
GO:0048291  isotype switching to IgG isotypes
GO:0002755  MyD88-dependent toll-like receptor signaling pathway
GO:0043066  negative regulation of apoptosis
GO:0043524  negative regulation of neuron apoptosis
GO:0043065  positive regulation of apoptosis
GO:0050729  positive regulation of inflammatory response
GO:0032727  positive regulation of interferon-alpha production
GO:0032729  positive regulation of interferon-gamma production
GO:0032733  positive regulation of interleukin-10 production
GO:0032735  positive regulation of interleukin-12 production
GO:0032755  positive regulation of interleukin-6 production
GO:0043032  positive regulation of macrophage activation
GO:0050870  positive regulation of T cell activation
GO:0002842  positive regulation of T cell mediated immune response to tumor cell
GO:0006457  protein folding
GO:0042026  protein refolding
GO:0050821  protein stabilization
GO:0006986  response to unfolded protein
GO:0042110  T cell activation

Cellular Component

GO:0009986  cell surface
GO:0005905  coated pit
GO:0030135  coated vesicle
GO:0019907  cyclin-dependent protein kinase activating kinase holoenzyme complex
GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0005769  early endosome
GO:0005615  extracellular space
GO:0005794  Golgi apparatus
GO:0043231  intracellular membrane-bounded organelle
GO:0046696  lipopolysaccharide receptor complex
GO:0045121  membrane raft
GO:0030061  mitochondrial crista
GO:0005743  mitochondrial inner membrane
GO:0005739  mitochondrion
GO:0005886  plasma membrane
GO:0005791  rough endoplasmic reticulum
GO:0030141  secretory granule
GO:0042588  zymogen granule

Molecular Function

GO:0005524  ATP binding
GO:0051087  chaperone binding
GO:0043559  insulin binding
GO:0001530  lipopolysaccharide binding
GO:0051787  misfolded protein binding
GO:0000166  nucleotide binding
GO:0002039  p53 binding
GO:0002020  protease binding
GO:0032403  protein complex binding
GO:0046982  protein heterodimerization activity