intersectin 1 (SH3 domain protein 1A)

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Synonym

AI316805, Intersectin-L, Itsn1, EH and SH3 domains protein 1, EHSH1, Eh domain, SH3 domain regulator of endocytosis 1, intersectin 1 (SH3 domain protein 1A), AA517634, Intersectin-1, AA545208, Itsn, Ese1, Intersectin, Sh3p17

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:199.70 cerebellum:165.80 brain stem:95.30 corpus callosum/glia:- pineal gland:- peripheral nerve:95.50 spine:94.60 retina:64.30 eye:152 artery/aorta:- vein:- lymphnode:86.40 peripheral blood:28.80 spleen:52.70 thymus:19.80 bone marrow:- adipose:212.70 bone:112.70 skin:39.60
GeneChip cerebrum:7.68 cerebellum:7.86 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:7.35 spine:8.28 retina:6.11 eye:6.75 artery/aorta:- vein:7.61 lymphnode:7.47 peripheral blood:- spleen:7.19 thymus:- bone marrow:8.65 adipose:7.88 bone:8.09 skin:6.97
CAGE cerebrum:3.30 cerebellum:- brain stem:3.06 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:3.19 retina:- eye:- artery/aorta:2.41 vein:- lymphnode:1.78 peripheral blood:- spleen:4.04 thymus:0.27 bone marrow:- adipose:- bone:3.38 skin:2.07
RNA-seq cerebrum:13.37 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:43.60 placenta:- prostate:30.90 ovary:68.90 testis:59.10 heart:- muscle:71 esophagus:- stomach:- intestine:- colon:-     liver/hepato:9.10        lung:60.30    bladder:- kidney:32.20 pituitary:- thyroid/parathyroid:112.50 adrenal gland:- pancreas:65.70 breast:52.20 salivary:-
GeneChip uterus:7.68 placenta:7.60 prostate:6.81 ovary:8.46 testis:7.15 heart:8.15 muscle:9.32 esophagus:- stomach:7.08 intestine:7.21 colon:- liver/hepato:7.72 lung:7.59 bladder:8.31 kidney:6.88 pituitary:7.15 thyroid/parathyroid:- adrenal gland:6.94 pancreas:6.45 breast:8.12 salivary:6.69
CAGE uterus:1.98 placenta:1.84 prostate:1.73 ovary:2.56 testis:1.89 heart:- muscle:- esophagus:- stomach:1.57 intestine:1.92 colon:1.96     liver/hepato:1.94    lung:2.17 bladder:2.29 kidney:- pituitary:1.56 thyroid/parathyroid:- adrenal gland:2.18 pancreas:1.84 breast:3.05 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:8.94 esophagus:- stomach:- intestine:- colon:-     liver/hepato:2.45        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_010587
Gene ID 16443
Unigene ID Mm.40546
Probe set ID 1425899_a_at  [Mouse430_2]
Ensembl ID ENSMUSG00000022957

Orthologous Gene

Human[4]  NM_001001132, NM_003024
Rat[2]  NM_001136096, NM_019227

Chromosomal Region

16C3.3  [91,729,526  -  91,920,842]

Gene Family (Interpro ID)

IPR000008  C2 calcium-dependent membrane targeting
IPR008973  C2 calcium/lipid-binding domain, CaLB
IPR018029  C2 membrane targeting protein
IPR002048  Calcium-binding EF-hand
IPR018249  EF-HAND 2
IPR001849  Pleckstrin homology
IPR013315  Spectrin alpha chain, SH3 domain
IPR020473  Src homology-3, region

Link to Pubmed  (Pubmed ID)

8889548
10064583
10349636
10373452
11042159
11076861
11217851
11544199
11744688
12466851
12466854
12466855
12477932
12520002
12686614
12904583
14610273
14681479
14964859
15203208
15345747
15782199
15824104
16141072
16141073
16452087
16798735
16914641
17114649
17182770
17540781
17875942
17967808
18539136
18676989
18692052
18799693
19666558
20160082
21267068
21349274
21677750
21712076
22158968
23447614
23633571
24197061
24216759

Gene Ontology  (GO ID)

Biological Process

GO:0006897  endocytosis
GO:0043524  negative regulation of neuron apoptosis
GO:0043085  positive regulation of catalytic activity
GO:0042327  positive regulation of phosphorylation
GO:0051897  positive regulation of protein kinase B signaling cascade
GO:0035023  regulation of Rho protein signal transduction
GO:0007264  small GTPase mediated signal transduction

Cellular Component

GO:0030054  cell junction
GO:0042995  cell projection
GO:0005905  coated pit
GO:0030139  endocytic vesicle
GO:0030027  lamellipodium
GO:0016020  membrane
GO:0043005  neuron projection
GO:0005886  plasma membrane
GO:0045202  synapse

Molecular Function

GO:0005509  calcium ion binding
GO:0005085  guanyl-nucleotide exchange factor activity
GO:0019209  kinase activator activity
GO:0046872  metal ion binding
GO:0005543  phospholipid binding
GO:0070064  proline-rich region binding
GO:0005515  protein binding
GO:0032947  protein complex scaffold
GO:0005089  Rho guanyl-nucleotide exchange factor activity